FDA and Opioids – WTF?

The U.S. already consumes 99% of the hydrocodone used in the world.


In 2010, Vicodin was the most prescribed medication in the U.S. with 131 million filled prescriptions. That same year, more than 16,000 people died of overdoses from narcotic painkillers, up from about 4,000 in 1999.

via FDA and Opioids: What’s Going On Here?.


Insurance Commissioner Urges Oklahomans to Buy Earthquake Coverage | News OK

Central Oklahoma has sustained more than 200 earthquakes with a magnitude of 3.0 or greater since January 2009, according to the U.S. Geological Survey.

via Insurance Commissioner urges Oklahomans to buy earthquake coverage | News OK.

Faithful readers are aware I bought earthquake coverage several years ago.

UPDATE 11.02.13

Our wake up call at 4:37 AM measured 3.7.

3.7 at 4:37 AM
3.7 at 4:37 AM

Bisphosphonates Raise Afib Risk

Bisphosphonate use was associated with significantly increased risks of atrial fibrillation and serious atrial fibrillation, researchers found.

A systematic review of randomized controlled studies and observational studies showed use of bisphosphonates was associated with a 27% increased risk of atrial fibrillation (95% CI 1.16-1.39) in observational studies and, in randomized controlled trials alone, with a 40% increased odds of serious atrial fibrillation (95% CI 1.02-1.93), according to Abhishek Sharma, MD, of Maimonides Medical Center in Brooklyn, N.Y., and colleagues.

via Bisphosphonates Raise Afib Risk.

Sleep Apnea Plays Role in Car Crashes

An estimated 20% to 50% of commercial drivers have sleep apnea. That high proportion may be in part due to the sedentary nature of long-haul trucking that contributes to obesity as a risk factor for sleep apnea, according to a statement from the American Academy of Sleep Medicine in support of federal legislation.

via Sleep Apnea Plays Role in Car Crashes.

Presented without the usual caustic comment.

Calcium Score Beats Lipids for Telling CVD Risk

Measurement of coronary artery calcium stratified patient risk for cardiovascular disease regardless of dyslipidemia burden or definition, researchers found.

When measured across lipid abnormality categories, patients with a coronary artery calcium score of 100 or more had a 22.2 to 29.2 incidents of cardiovascular disease per 1,000 person-years versus 2.4 to 6.2 events per 1,000 person-years among those with arterial calcium scores of 0, according to Khurram Nasir, MD, MPH, of Baptist Health South Florida in Miami Beach, and colleagues.

via Calcium Score Beats Lipids for Telling CVD Risk.

Stroke Numbers Up Worldwide

In 2010, there were 16.9 million people who had a first stroke, 33 million stroke survivors, and 5.9 million people who died from a stroke — increases of 68%, 84%, and 26% respectively since 1990, according to Valery Feigin, MD, of the Auckland University of Technology in New Zealand, and colleagues.

Stroke mortality rates fell significantly in both groups of countries: by 37% in high-income countries and by 20% in low- and middle-income countries.

via Stroke Numbers Up Worldwide.

Sleep Apnea Severity Tied to Cardiac Marker

  • Obstructive sleep apnea is associated with cardiovascular morbidity and mortality, particularly heart failure, a study found.
  • The severity of obstructive sleep apnea was significantly associated with higher levels of high-sensitivity troponin, suggesting that subclinical myocardial injury may play a role in the association with risk of heart failure.

via Sleep Apnea Severity Tied to Cardiac Marker.