PodMed From Johns Hopkins 01.31.14

PodMed: A Medical News Roundup From Johns Hopkins.

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Testosterone Treatment and MI Risk

Filling a prescription for testosterone therapy was associated with a greater risk of having a nonfatal myocardial infarction (MI) in the next 3 months, a large observational study showed.

The risk after a prescription was filled was more than doubled in men 65 and older overall compared with that in the year before the prescription (rate ratio 2.19, 95% CI 1.27-3.77), according to Robert Hoover, MD, ScD, of the National Cancer Institute in Bethesda, Md., and colleagues.

The study was limited, however, by the observational design, the use of administrative data that lacked information on indications for treatment, and the inclusion of nonfatal MIs only.

via Study Feeds Concerns About MI Risk With Testosterone Tx.

Acetaminophen Prescription Combination Drug Products with more than 325 mg: FDA Statement – Recommendation to Discontinue Prescribing and Dispensing

ISSUE: FDA is recommending health care professionals discontinue prescribing and dispensing prescription combination drug products that contain more than 325 milligrams (mg) of acetaminophen per tablet, capsule or other dosage unit. There are no available data to show that taking more than 325 mg of acetaminophen per dosage unit provides additional benefit that outweighs the added risks for liver injury. Further, limiting the amount of acetaminophen per dosage unit will reduce the risk of severe liver injury from inadvertent acetaminophen overdose, which can lead to liver failure, liver transplant, and death.

via Safety Alerts for Human Medical Products > Acetaminophen Prescription Combination Drug Products with more than 325 mg: FDA Statement – Recommendation to Discontinue Prescribing and Dispensing.

You like your liver?  You can keep your liver.

Smart Appliances Hacked – over 750k Malicious Emails Sent – SlashGear

A security service provider called Proofpoint has issued a report detailing what it believes to be the first documented attack on the Internet of Things. According to the report, over 750,000 malicious emails were sent out using over 100,000 compromised devices on the Internet of Things. The compromised devices include appliances, routers, TVs, and connected refrigerators.

via Smart appliances hacked to send out over 750k malicious emails – SlashGear.

Body-Mass Index and Mortality among Adults with Incident Type 2 Diabetes — NEJM

Conclusions

We observed a J-shaped association between BMI and mortality among all participants and among those who had ever smoked and a direct linear relationship among those who had never smoked. We found no evidence of lower mortality among patients with diabetes who were overweight or obese at diagnosis, as compared with their normal-weight counterparts, or of an obesity paradox.

via Body-Mass Index and Mortality among Adults with Incident Type 2 Diabetes — NEJM.