Five Lessons From the Niacin Failure

Five Lessons From the Niacin Failure.

Niacin With Statins? No Dice..

HPS2-THRIVE: As Niacin Fails, HDL’s Role Is Debated Anew.

Enjoy these articles.  Taking niacin?  Well…


Emergency Medicine News – THC Dosing of Edible Marijuana in Colorado is Insane.

Avoid couchlock! Four things to know about cannabis pharmacology | The Poison Review.

Recently, the New York Times’ Pulitzer Prize-winning columnist Maureen Dowd got into trouble in Denver when she overdosed on a cannabis candy bar and experienced 8 hours of paranoia and couchlock.

Toxicology Rounds: Four Things Maureen Dowd Should Have Know… : Emergency Medicine News.

THC dosing of edible marijuana in Colorado is insane. Richard Zane, MD, the chairman of emergency medicine at the University of Colorado Medical Center in Denver, said on the National Public Radio talk show On Point that the amount of THC in some marijuana edibles is completely irrational. The usual recommended moderate starting dose is approximately 10 mg THC, and some cookies can contain six doses and some lollipops as many as 10. Dr. Zane said the university’s ED sees out-of-state marijuana tourists every day who present with bad reactions to THC, such as agitation, unremitting violent vomiting, hallucinations, and psychosis.

And finally, a link to Maureen Dowd’s column.

Don’t Harsh Our Mellow, Dude –

In March, a 19-year-old Wyoming college student jumped off a Denver hotel balcony after eating a pot cookie with 65 milligrams of THC. In April, a Denver man ate pot-infused Karma Kandy and began talking like it was the end of the world, scaring his wife and three kids. Then he retrieved a handgun from a safe and killed his wife while she was on the phone with an emergency dispatcher.

JAMA – Treating Prescription Opioid Dependence

JAMA Network | JAMA | Treating Prescription Opioid Dependence.

Conclusions and Relevance This study represents a rigorous experimental evaluation of outpatient buprenorphine stabilization, brief taper, and naltrexone maintenance for treatment of PO dependence. Results suggest that a meaningful subset of PO-dependent outpatients may respond positively to a 4-week


Naltrexone maintenance?  I bet they’ll lost weight too.

Diet Soda May Alter Our Gut Microbes And Raise The Risk Of Diabetes : The Salt : NPR

Now, a new study published in the journal Nature introduces a new idea: Diet sodas may alter our gut microbes in a way that increases the risk of metabolic diseases such as Type 2 diabetes — at least in some of us.

In the paper, researchers at the Weizmann Institute of Science in Israel describe what happened when they fed zero-calorie sweeteners, including saccharin, aspartame and sucralose, to mice.

“To our surprise, [the mice] developed glucose intolerance,” Weizmann researcher Eran Elinav tells us.

Artificial sweeteners induce glucose intolerance by altering the gut microbiota : Nature : Nature Publishing Group.

Diet Soda May Alter Our Gut Microbes And Raise The Risk Of Diabetes : The Salt : NPR.

Wealthy L.A. Schools’ Vaccination Rates Are as Low as South Sudan’s – The Atlantic

Wealthy L.A. Schools’ Vaccination Rates Are as Low as South Sudan’s – The Atlantic.

When actors play doctors on TV, that does not make them actual doctors. And that does not mean they should scour some Internet boards, confront their pediatricians, and demand fewer vaccinations for their children, as some Hollywood parents in Los Angeles have apparently been doing.

The Hollywood Reporter has a great investigation for which it sought the vaccination records of elementary schools all over Los Angeles County. They found that vaccination rates in elite neighborhoods like Santa Monica and Beverly Hills have tanked, and the incidence of whooping cough there has skyrocketed.

I guess these “enlightened” parents know little about community immunity.

You can’t fix stupid.

Community Immunity “Herd” Immunity.

Study Finds Antidepressants Change Brain Connectivity in Just a Few Hours

No wonder why SRRI’s are so addictive.


A new study published in the journal Current Biology Thursday found that a single dose of some of the most widely used antidepressants change the brain’s architecture after only a few hours.

However, patients who take drugs to treat depression usually don’t report any improvement until weeks later, the L.A. Times reports.

Researchers hope their findings will allow doctors to determine whether or not a patient will respond to certain psychiatric drugs by way of a brain scan.

Low levels of the chemical transmitter serotonin in the brain are associated with depression. Antidepressants work by blocking how serotonin is reabsorbed into the brain.

The drugs are known as Selective Serotonin Reuptake Inhibitors, or SSRIs.

To conduct the study, researchers compared connections in the brain’s gray matter of patients who took antidepressants and those who did not, the Times reports.

“We just tell them to let their minds wander and not…

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