BMJ Group blogs: BMJ » Blog Archive » Richard Lehman’s journal review – 11 October 2010
Most medical research is clinically useless, and so, sadly, are most systematic reviews and meta-analyses.
The quote is from Lehman, not me.
underwriting
A Record 79 Americans Killed in Mexico – 2009
Lehman’s Journal Review 10.4.2010
BMJ Group blogs: BMJ » Blog Archive » Richard Lehman’s journal review, 4 October 2010
Like about 40% of adults of my age in Western countries, I have a fatty liver, though I don’t qualify for having nonalcoholic fatty liver disease because I drink too much. If I wanted to know what is really happening to my liver I would have to have serial biopsies, as would several million people in the UK. This non-disease correlates with a number of other non-diseases such as asymptomatic reduced left systolic ejection fraction and pre-diabetes, and some real risk factors such as actual diabetes and high blood pressure. So I might die of vascular disease; or liver failure if I really overdo the wine; or else from cancer or general crumble or whatever else awaits me and everyone else. This paper on the risk of cardiovascular disease in patients with nonalcoholic fatty liver disease goes through the data and leaves me none the wiser: and by the way, these people are not patients and they don’t have a disease.
General crumble?
Low Carb Diets and Mortality
Low-Carbohydrate Diets and All-Cause and Cause-Specific Mortality — Ann Intern Med
Conclusion: A low-carbohydrate diet based on animal sources was associated with higher all-cause mortality in both men and women, whereas a vegetable-based low-carbohydrate diet was associated with lower all-cause and cardiovascular disease mortality rates.
Getting Closer – The War to Our South (Texas)
Kapvay (clonidine hydrochloride)
Underwriting Quick Notes
Kapvay = brand name
Shionogi = manufacturer
High Noise Levels and CHD
There are several ways in which noise could contribute to cardiovascular events, according to the researchers. One is through the development of isolated diastolic hypertension, which has been shown to independently predict CHD and is more common among younger individuals.
The stress caused by loud noise also might lead to activation of the endocrine and sympathetic nervous systems, resulting in vasoconstriction, occlusion, and plaque disruption, they explained.
A limitation of the study was the possibility of selection bias. Workers who don’t tolerate noise or who have cardiovascular disease could have moved to other, less stressful jobs — or could have died while still in their noisy jobs.
Hypoglycemia in DM2 = Higher Mortality Risk
Type 2 diabetes patients who experienced these serious drops in blood glucose had nearly three times the risk of death and twice the risk of a major macrovascular event compared with those who didn’t experience hypoglycemia, Sophia Zoungas, MD, PhD, of the University of Sydney in Australia, and colleagues reported in the New England Journal of Medicine.
lifeunderwriter.net 
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