When you just want to play guitar but your dad was in Pink Floyd. pic.twitter.com/b64pYG3bEl
— No Context Brits (@NoContextBrits) January 6, 2023
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Cannabinoid Hyperemesis Syndrome
It’s not entirely clear how cannabis hyperemesis syndrome occurs though there are several theories. One is that since cannabinoids have long-half lives and are lipid soluble, they accumulate in the brain and over time cause symptoms, particularly in young people who may have genetic variations in enzymes which lead to further accumulation. Another theory is that there is a thermoregulatory and autonomic imbalance in the limbic system caused by chronic use. Other suggestions are that with long-term consumption cannabis becomes a receptor antagonist, or that they become down-regulated or de-sensitised over time. This reverses the antiemetic effect of cannabis. It seems that chronic over-stimulation of receptors leads to dysregulation of the body’s control of nausea and vomiting, leading to CHS.
Owen Hibberd . What you need to know about Cannabinoid Hyperemesis Syndrome, Don’t Forget the Bubbles, 2022. Available at: https://doi.org/10.31440/DFTB.48627
I am so glad I never inhaled.
Thinking About a Booster Shot?
Protection with a Third Dose of mRNA Vaccine against SARS-CoV-2 Variants in Frontline Workers — https://www.nejm.org/doi/full/10.1056/NEJMc2201821?af=R&rss=currentIssue
No quotes provided because I want you to read the original article.
Benzodiazepines Implicated in High Rate of ED Visits Across US
Seven out of eight emergency department (ED) visits attributed to adverse events from benzodiazepines involve self-harm or nonmedical use of these drugs, and more than 80% involve concurrent use of alcohol, illicit drugs, or other substances, new research shows.
Although benzodiazepines are typically not problematic in terms of acute overdoses when used alone, patients often don’t take them as prescribed or use them with other substances in a self-harm attempt, author Daniel S. Budnitz, MD, MPH, director of the Medication Safety Program, Centers for Disease Control and Prevention (CDC), told Medscape Medical News.
“Clinicians need to be aware of what other substances patients might be taking when they’re being prescribed a benzodiazepine,” Budnitz added.
The study was published online February 19 in the American Journal of Preventive Medicine.
Benzodiazepines Implicated in High Rate of ED Visits Across US – Medscape – Feb 25, 2020 – https://www.medscape.com/viewarticle/925686#vp_1
Love the Zeroes
Ashish K. Jha, MD, MPH, is a physician, health policy researcher, and the third Dean of the Brown University School of Public Health. Before joining Brown, he was the K.T. Li Professor of Global Health at the Harvard T.H. Chan School of Public Health and Director of the Harvard Global Health Institute (HGHI).
https://www.brown.edu/academics/public-health/about/people/dean/ashish-jha
I would not take Covaxin without efficacy data: Gagandeep Kang — Science Chronicle
Serum’s Covishield and Bharat Biotech’s Covaxin are examples of atmanirbhar (self-reliance) but have an element of non-Indian science — and at least to me that is fine, says Dr. Gagandeep Kang. Though Covaxin uses inactivated virus, neutralising antibodies against the spike protein are critical for reinfection. So if Covaxin is based on an old viral […]
I would not take Covaxin without efficacy data: Gagandeep Kang — Science Chronicle
NEJM Journal Watch – Infectious Diseases and Cardiology Top Stories of 2020 (links to more links)
Oxford vaccine shows 90% efficacy in Phase-3 trial — Science Chronicle
Interim data analysis of Phase-3 trial of Oxford/AstraZeneca COVID-19 candidate vaccine (ChAdOx1 nCoV-2019) showed different efficacies in preventing COVID-19 disease. In the case of the regimen where a halved dose was used as a prime (first dose) followed by a standard dose of booster, the efficacy was 90%. However, when full doses (standard doses) were […]
Oxford vaccine shows 90% efficacy in Phase-3 trial — Science Chronicle
Attention Parents! Read This – Covid-19 GI Symptoms Common in Children
A prospective study of 992 healthy children (median age 10.1 years) of healthcare workers from across the UK found that 68 (6.9%) tested positive for SARS-CoV-2 antibodies.1 Half of the children testing positive reported no symptoms, but for those that did the commonest were fever (21 of 68, 31%); gastrointestinal symptoms, including diarrhoea, vomiting, and abdominal cramps (13 of 68, 19%); and headache (12 of 68, 18%). Latest findings from the Covid-19 Symptom Study app,2 which was launched in late March to track people’s symptoms, also show that gastrointestinal symptoms occur frequently in children with positive swab tests.3
Covid-19: UK studies find gastrointestinal symptoms are common in children — Citation: BMJ 2020;370:m3484 — https://www.bmj.com/content/370/bmj.m3484
Researchers report nearly 300 cases of inflammatory syndrome tied to Covid-19 in kids
Researchers report nearly 300 cases of inflammatory syndrome tied to Covid-19 in kids
Addendum to Post Pandemic Changes in Consumer Behavior.
Home schooling. A lot more home schooling.
With approximately 1000 cases of MIS-C (including, here and below, those that have been classified as PIMS-TS) reported worldwide, do we now have a clear picture of the new disorder, or, as in the story of the blind men and the elephant, has only part of the beast been described? What are its cause and pathogenesis? How should it be diagnosed and treated, and are there wider implications for our understanding of Covid-19?
Update 07.02.20
COVID-19 in Kids: New Neurologic, Radiographic Findings
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