Benzodiazepines Implicated in High Rate of ED Visits Across US

Seven out of eight emergency department (ED) visits attributed to adverse events from benzodiazepines involve self-harm or nonmedical use of these drugs, and more than 80% involve concurrent use of alcohol, illicit drugs, or other substances, new research shows.

Although benzodiazepines are typically not problematic in terms of acute overdoses when used alone, patients often don’t take them as prescribed or use them with other substances in a self-harm attempt, author Daniel S. Budnitz, MD, MPH, director of the Medication Safety Program, Centers for Disease Control and Prevention (CDC), told Medscape Medical News.

“Clinicians need to be aware of what other substances patients might be taking when they’re being prescribed a benzodiazepine,” Budnitz added.

The study was published online February 19 in the American Journal of Preventive Medicine.

Benzodiazepines Implicated in High Rate of ED Visits Across US – Medscape – Feb 25, 2020 – https://www.medscape.com/viewarticle/925686#vp_1

Love the Zeroes

Downloaded from Twitter 02.01.21. Chart created by Dr. Jha

Ashish K. Jha, MD, MPH, is a physician, health policy researcher, and the third Dean of the Brown University School of Public Health. Before joining Brown, he was the K.T. Li Professor of Global Health at the Harvard T.H. Chan School of Public Health and Director of the Harvard Global Health Institute (HGHI).

https://www.brown.edu/academics/public-health/about/people/dean/ashish-jha

I would not take Covaxin without efficacy data: Gagandeep Kang — Science Chronicle

Serum’s Covishield and Bharat Biotech’s Covaxin are examples of atmanirbhar (self-reliance) but have an element of non-Indian science — and at least to me that is fine, says Dr. Gagandeep Kang. Though Covaxin uses inactivated virus, neutralising antibodies against the spike protein are critical for reinfection. So if Covaxin is based on an old viral […]

I would not take Covaxin without efficacy data: Gagandeep Kang — Science Chronicle

Oxford vaccine shows 90% efficacy in Phase-3 trial — Science Chronicle

Interim data analysis of Phase-3 trial of Oxford/AstraZeneca COVID-19 candidate vaccine (ChAdOx1 nCoV-2019) showed different efficacies in preventing COVID-19 disease. In the case of the regimen where a halved dose was used as a prime (first dose) followed by a standard dose of booster, the efficacy was 90%. However, when full doses (standard doses) were […]

Oxford vaccine shows 90% efficacy in Phase-3 trial — Science Chronicle

Attention Parents! Read This – Covid-19 GI Symptoms Common in Children

A prospective study of 992 healthy children (median age 10.1 years) of healthcare workers from across the UK found that 68 (6.9%) tested positive for SARS-CoV-2 antibodies.1 Half of the children testing positive reported no symptoms, but for those that did the commonest were fever (21 of 68, 31%); gastrointestinal symptoms, including diarrhoea, vomiting, and abdominal cramps (13 of 68, 19%); and headache (12 of 68, 18%). Latest findings from the Covid-19 Symptom Study app,2 which was launched in late March to track people’s symptoms, also show that gastrointestinal symptoms occur frequently in children with positive swab tests.3

Covid-19: UK studies find gastrointestinal symptoms are common in children — Citation: BMJ 2020;370:m3484 — https://www.bmj.com/content/370/bmj.m3484

Researchers report nearly 300 cases of inflammatory syndrome tied to Covid-19 in kids

Researchers report nearly 300 cases of inflammatory syndrome tied to Covid-19 in kids

Addendum to Post Pandemic Changes in Consumer Behavior.

Home schooling.  A lot more home schooling.

With approximately 1000 cases of MIS-C (including, here and below, those that have been classified as PIMS-TS) reported worldwide, do we now have a clear picture of the new disorder, or, as in the story of the blind men and the elephant, has only part of the beast been described? What are its cause and pathogenesis? How should it be diagnosed and treated, and are there wider implications for our understanding of Covid-19?

Link to the NEJM article.

Update 07.02.20

COVID-19 in Kids: New Neurologic, Radiographic Findings

 

Risk Factors for Death From COVID-19 Identified in Wuhan

Fei Zhou, MD, from the Chinese Academy of Medical Sciences, and colleagues conducted a retrospective, observational, multi-center cohort study of 191 patients, 137 of whom were discharged and 54 of whom died in the hospital.

The study, published online today in The Lancet, included all adult inpatients with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital who had been discharged or died by January 31 of this year. Severely ill patients in the province were transferred to these hospitals until February 1.

Overall, 91 (48%) of the 191 patients had comorbidity. Most common was hypertension (30%), followed by diabetes (19%) and coronary heart disease (8%)…The average age of survivors was 52 years compared to 69 for those who died. Liu cited weakening of the immune system and increased inflammation, which damages organs and also promotes viral replication, as explanations for the age effect.

Click the link below for the full source article.

Risk Factors for Death From COVID-19 Identified in Wuhan Patients