Human Lab Rats

America’s Poison Centers logged 862 exposures to retatrutide in the three months ending in September, up from 460 in the prior three months and 249 in the first three months of 2026, CBS News reported. The FDA has also received two reports of people who died after taking products sold as retatrutide, an experimental Eli Lilly obesity drug that no regulator has approved. Poison Center Exposures to Bootleg Retatrutide Nearly Double in Three Months as FDA Logs Two Death Reports – https://www.medicaldaily.com/retatrutide-poison-center-exposures-fda-death-reports-479901

Meanwhile in Australia…

The medicines regulator has revealed a patient suffered a torn oesophagus after using an unapproved weight-loss peptide labelled as retatrutide. Laboratory testing found the product contained no retatrutide, but instead a high dose of undeclared weight-loss drug semaglutide. Retatrutide is currently undergoing clinical trials in humans and has not been approved by the Therapeutic Goods Administration. Patient suffers torn oesophagus after using unapproved peptide, prompting fresh warnings – https://www.abc.net.au/news/2026-09-14/tga-peptide-warning-retatrutide-torn-oesophagus/107143510

The department has been notified of six cases of acute liver toxicity associated with an unapproved peptide product in Australia, labelled Retatrutide. Toxicity linked to unapproved peptide product labelled Retatrutide – https://www.health.vic.gov.au/health-alerts/toxicity-linked-to-unapproved-peptide-retatrutide

Emergency visits linked to peptide use in Australia surged 4,240%, from five in July 2025 to 217 in September 2026. Social media influencers promote peptides for weight loss, muscle growth, injury recovery and anti-aging, but unapproved products may pose risks due to uncertain composition, quality and safety. Retatrutide Driving Peptide-Linked Emergency Hospital Admissions In Australia: What Are The Risks? – https://www.healthandme.com/health-news/retatrutide-driving-peptide-linked-emergency-hospital-visits-in-australia-what-are-the-risks-article-156365185

In Silicon Valley, devotees have gathered at peptide parties to drink, dance and inject themselves with these chemicals—all in pursuit of sharper minds and more sculpted bodies. But within the last few years, peptides have become a much broader phenomenon, not just taken for self-optimization but for treating chronic pain and various other conditions…“We’re seeing a new rival or parallel health system emerge,” says Daniel Carpenter, chair of the government department at Harvard University and an expert in FDA regulation, “built on self-diagnosis and easy access to a wide range of treatments.” Peptides Are All the Rage, Promising Miracle Cures and Makeovers Delivered by Injection. How Did We Get Here? – https://www.smithsonianmag.com/science-nature/peptides-are-all-the-rage-promising-miracle-cures-and-makeovers-delivered-by-injection-how-did-we-get-here-180989454/

Source article for the post title – The Human Lab Rats Injecting Themselves with Peptides https://www.mcgill.ca/oss/article/critical-thinking-health-and-nutrition/human-lab-rats-injecting-themselves-peptides

The lack of critical thinking and absence of common sense astounds me.

Yikes.

A Severe Threat to Fundamental Learning Processes

“Casual, careless use of general-purpose GenAI can threaten the very learning processes necessary for committing new ideas to memory… and also the higher-order thinking needed to deeply understand and use these ideas in novel ways,” report authors wrote.

Kendeou said experts expressed extra caution when it comes to introducing AI to primary school students because of the skills being introduced and practiced at that age.

In writing, for example, Kendeou said students need to learn to put their thoughts in writing on their own before using a tool that does that task for them. University of Minnesota report warns student AI use poses ‘severe’ threat to learning – https://www.mprnews.org/story/2026/10/28/university-of-minnesota-report-warns-student-ai-use-poses-severe-threat-to-learning

While the long-term research on AI’s direct impact on learning is still in its infancy, the consensus among experts is chilling. We’re talking about potential disruptions to memory formation and the development of higher-order thinking skills – the kind of cognitive abilities that truly define a well-rounded education. This goes beyond the usual tech-in-the-classroom debates. We’re grappling with deep ethical concerns, from data privacy and algorithmic bias to the very integrity of academic work. As AI tools become increasingly common in schools, state education leaders are scrambling to respond, moving from vague guidance to concrete policy. The stakes couldn’t be higher, and the conversation is only just beginning. 8 Disturbing Ways Student AI Use Could Be Harming Kids’ Minds – https://www.theedadvocate.org/8-disturbing-ways-student-ai-use-could-be-harming-kids-minds/

Read the full report here: https://www.cehd.umn.edu/AI-expert-consensus-report-2026

Yikes

Improve Your Child’s Academic Performance!

Phone ban impact on student academic achievement

The top estimate is the estimated average treatment effect of the phone ban on student academic achievement across the full population. The next estimates contain heterogeneous treatment effects for subgroups split by prior average academic achievement (above or below preexperiment median), years of study, and field of study.

Source: Alp Sungu et al.,Phones impede learning: Evidence from a massive phone-free classroom experiment.Science394,178-181(2026).DOI:10.1126/science.aef7249 https://www.science.org/doi/10.1126/science.aef7249

I’m Taking Your Phone Away (and you didn’t do anything wrong)

When People Did Not Have Access to Mobile Internet, they Spent More Time Socializing in Person, Exercising, and Being in Nature.

Wait…I need to check my phone.

Improve Your Child’s Mental Health and Academic Performance!

Results  This study included 5515 adolescent participants (2640 [47.9%] female; mean [SD] age 11.93 [0.65] years) using step counters. Higher step count was associated with lower total mental health problems (B [SE], −0.080 [0.015]; t = −5.497; P < .001) and greater cortical thickness in the paracentral (B [SE], 0.057 [0.016]; t = 3.621; P < .001) and rostral anterior cingulate (B[SE], 0.052 [0.016]; t = 3.319; P = .001) regions. Further analyses showed a significant dose-response association, with progressively lower mental health problems across higher step categories compared with the under 5000-step group. Mediation analyses revealed that greater paracentral thickness statistically mediated the association between higher daily step count and fewer mental health problems 1 year later.

Conclusions and Relevance  In this cohort study, higher daily step counts were associated with structural differences in the brains of adolescents, which were in turn associated with better mental outcomes prospectively. Beneficial associations for mental health appeared to accrue continuously across the observed range, with no evidence of a threshold or plateau, highlighting that every step counts and the potential value of promoting daily steps in adolescents. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2854698

Li Q, Paluch A, Rakesh D. Physical Activity and Adolescent Brain Structure, Mental Health, and Academic Outcomes. JAMA Netw Open. 2026;9(10):e2636973. doi:10.1001/jamanetworkopen.2026.36973

Greater cortical thickness too!

WOOHOO.

I Hope My Perivascular Fat Attenuation Index (FAI) Score is Low

New research continues to affirm the prognostic utility of the coronary computed tomography angiography (CCTA)-derived perivascular fat attenuation index (FAI) score in assessing cardiovascular risks for patients without common risk factors such as smoking history, obesity, hypertension and diabetes. What CCTA-Based AI Detection of Coronary Inflammation May Reveal About Patients with No Traditional CV Risk Factors – https://www.diagnosticimaging.com/view/ccta-based-ai-detection-coronary-inflammation-patients-with-no-traditional-cv-risk-factors

Image Source: The Coronary Artery Inflammation Controversy – https://erictopol.substack.com/p/the-coronary-artery-inflammation

Dr. Topel has an extensive analysis of this new diagnostic tool.

But I’m pretty sure the $49.00 heart scan at https://www.okheart.com/services/heartview-ct-heart-scan/ won’t tell me my FAI score.

Resistance is NOT Futile (in DM risk)

In this prospective cohort study, resistance training among US adult health care professionals was associated with substantially lower T2D risk, particularly when performed consistently over midlife and combined with adequate aerobic activity and limited sedentary television viewing. These findings support the inclusion of resistance training as a key component of lifestyle recommendations for diabetes prevention. Long-Term Resistance Training and Risk of Type 2 Diabetes – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2850563

Not Everyone Gets Lucky

My interviews with Howard Marks, Chairman of Oaktree Capital, and famed for his “Chairman’s Memos,” were instructive.1 The first time he mentioned his good fortune, I pushed back, asking, “What about intelligence, hard work, and perseverance?”

His answer:

“Everybody in my MBA class at the University of Chicago was very smart and very hard working. But hard work and intelligence are mere table stakes. Not everybody has fortune smile on them; not everybody gets lucky.”


Serendipity: The Role of Luck in Your Life and Career – https://ritholtz.com/2026/06/recognize-the-role-of-luck-in-your-life-and-career/

The older you get you do develop a better understanding of luck and random events. Interesting article.

Not everyone gets lucky.

Study Failure to Learn Success

Michael Girdley on private equity:

The lesson is pretty straightforward. You’re going to go buy a business, and you’re going to look and say, “Where can I cut costs? How can I start to optimize and streamline this?” You can cut fat, but you definitely don’t want to cut muscle, and you don’t want to cut bone. That’s exactly what these guys did. Why did they do that? They’re private equity guys. They get paid on management fees and the deals when they turn around and put them out in the public. They don’t care about the long term. They care about the next three to five years, and that’s exactly what they optimized for.