Dumb and Dumber – Noncompliance with Colonoscopy Post Positive FIT

Results Some 88 013 patients who were FIT positive complied with colonoscopy (males: 56.1%; aged 50–59 years: 49.1%) while 23 410 did not (males: 54.6%; aged 50–59 years: 44.9%).

The 10-year cumulative incidence of CRC was 44.7 per 1000 (95% CI, 43.1 to 46.3) among colonoscopy compliers and 54.3 per 1000 (95% CI, 49.9 to 58.7) in non-compliers, while the cumulative mortality for CRC was 6.8 per 1000 (95% CI, 5.9 to 7.6) and 16.0 per 1000 (95% CI, 13.1 to 18.9), respectively. The risk of dying of CRC among non-compliers was 103% higher than among compliers (adjusted HR, 2.03; 95% CI, 1.68 to 2.44).

Conclusion The excess risk of CRC death among those not completing colonoscopy after a positive faecal occult blood test should prompt screening programmes to adopt effective interventions to increase compliance in this high-risk population.

Non-compliance with colonoscopy after a positive faecal immunochemical test doubles the risk of dying from colorectal cancer — https://gut.bmj.com/content/early/2021/03/30/gutjnl-2020-322192?rss=1

Help me understand human behavior. You get a positive FOBT or Cologuard test and your doctor says you need a colonoscopy but you decide not to follow up and follow through with the scope.

SMH.

Indian scientists divided over restricted use approval for Covaxin — Science Chronicle

While some scientists have raised concerns about granting restricted use approval to Covaxin even in the absence of efficacy data, four-dozen scientists have in a statement slammed them saying “reprehensible utterances are causing huge credibility crisis for the Indian scientific community”. Apparently, questioning the approval process by the Indian regulator is seen as being anti-Indian […]

Indian scientists divided over restricted use approval for Covaxin — Science Chronicle

India’s drug regulator approved two COVID-19 vaccines on 3 January, a decision Prime Minister Narendra Modi hailed on Twitter as “a decisive turning point to strengthen a spirited fight!” against the pandemic and a testament to the Indian scientific community’s self reliance. But some scientists and patient advocates are sharply critical of the move—in particular, the decision to greenlight Covaxin, a vaccine developed in India by Bharat Biotech, without awaiting the results of a phase III trial to determine efficacy and safety…

Efficacy data from a challenge study in rhesus macaques and immune responses in a human phase II trial suggested the vaccine was likely to be very effective.

The approval of a vaccine without phase III data is “unconscionable,” says Vineeta Bal, an immunologist at India’s National Institute of Immunology.

Scientists criticize ‘rushed’ approval of Indian COVID-19 vaccine without efficacy data — https://www.sciencemag.org/news/2021/01/scientists-criticize-rushed-approval-indian-covid-19-vaccine-without-efficacy-data

It worked in monkeys so let’s just skip the Phase III trial.

See my earlier post I would not take Covaxin without efficacy data: Gagandeep Kang — Science Chronicle

Taxpayers Face $435 Billion in Student-Loan Losses

Taxpayers face a loss of $435 billion on the $1.37 trillion in student loans on the government’s financial statement at the beginning of this year, even if no additional loans are issued going forward, according to an internal study by the Department of Education, reported by the Wall Street Journal which reviewed the documents. Most of the losses would come from the already established income-based repayment programs and the debt forgiveness at the end of their term.

But who ultimately got this money, since students were just the conduit? The educational-financial-industrial complex, of course, the entities that have lined up to clean out the taxpayer via these student loans. Billionaires have been printed in the process, enabled and encouraged by the government since 2009. Any solution to the student-loan crisis needs to include measures that shut down that money-transfer and return the government’s role in student loans to where it had been before 2009.

Taxpayers Face $435 Billion in Student-Loan Losses, Already Baked in: Leaked Education-Department Study — https://wolfstreet.com/2020/11/22/taxpayers-face-435-billion-in-student-loan-losses-already-baked-in-department-of-education-study/

And let’s not forget who The Great Enabler was behind the college leaders’ lack of caring for their students College Presidents Fail to Protect Students from Covid-19 – College Clusterfuck Update 11.22.20. Politicians, of course.

We. Are. Doomed.

Diets Don’t Work so Why Are More Teens Dieting?

Well, my first thought was Body Dysmorphic Disorder (BDD) — https://adaa.org/understanding-anxiety/related-illnesses/other-related-conditions/body-dysmorphic-disorder-bdd. But this is merely an educated guess from an insurance guy who has lost 200 pounds and not a trained licensed practicing clinical psychiatrist.

In 2015, 42% of 14-year-old girls and boys said they currently were trying to lose weight, compared to 30% in 2005.

Lead author Dr Francesca Solmi (UCL Psychiatry) said: “Our findings show how the way we talk about weight, health and appearance can have profound impacts on young people’s mental health, and efforts to tackle rising obesity rates may have unintended consequences.

“An increase in dieting among young people is concerning because experimental studies have found that dieting is generally ineffective in the long term at reducing body weight in adolescents, but can instead have greater impacts on mental health. We know, for instance, that dieting is a strong risk factor in the development of eating disorders.”

University College London. “Dieting and weight worries on rise in teens.” ScienceDaily. http://www.sciencedaily.com/releases/2020/11/201116112855.htm (accessed November 21, 2020). — https://www.sciencedaily.com/releases/2020/11/201116112855.htm

And in case you made it this far on this blog post my estimated BMI at age 20 was 53.1. My current BMI is 25.1.

Can 2020 Get Any Worse? (si)

Until now, there had been only one confirmed case of Chapare virus, an Ebola-like illness that turned up in the rural Bolivian province of Chapare in 2004 and then disappeared. But in 2019, at least five more people caught the bug, according to research now made public. The virus spread from person to person through bodily fluids in a region near Bolivia’s capital city of La Paz, killing three people. There are no active outbreaks of Chapare in 2020, and even in the event of further outbreaks the virus would be unlikely to cause a pandemic, according to virus experts.

There are reasons to be concerned about the news, however. Three of the five confirmed patients from the 2019 outbreak were health care workers, according to a CDC statement; a “young medical resident,” an ambulance medic and a gastroenterologist all contracted Chapare after contact with bodily fluids from infected patients. Two of them died.

Deadly hemorrhagic fever in Bolivia can spread between people — https://www.livescience.com/chapare-virus-human-transmission.htm

In my next life I want to come back as an Infectious Disease specialist.

Covid-19 Data and Rapid Testing

Rapid Covid-19 tests are being deployed by the millions across the nation. The federal government is sending these tests, which can provide results in minutes, to states for educators, students, nursing home patients, first responders, and other sites. That’s a good thing. But in a rush to get individual test results, we’re making a dangerous public health mistake: We’re losing critical data about Covid-19.

For months, the U.S. has struggled to get accurate information about Covid-19 cases and testing about different demographic groups. As rapid tests surge — and are performed at sites that don’t follow specific Covid-19 data reporting processes — even more information will be lost.

The hidden public health hazard of rapid Covid-19 tests — https://www.statnews.com/2020/11/05/rapid-covid-19-tests-hidden-public-health-hazard/?utm_campaign=rss

Colleges’ Opening Fueled 3,000 COVID Cases a Day (College Clusterfuck Update)

The study, done jointly by researchers at the University of North Carolina-Greensboro, Indiana University, the University of Washington and Davidson College, tracked cellphone data and matched it to reopening schedules at 1,400 schools, along with county infection rates.

Colleges’ Opening Fueled 3,000 COVID Cases a Day, Researchers Say — https://khn.org/news/colleges-opening-fueled-3000-covid-cases-a-day-researchers-say/

A majority of young adults in the U.S. live with their parents for the first time since the Great Depression

In July, 52% of young adults resided with one or both of their parents, up from 47% in February, according to a new Pew Research Center analysis of monthly Census Bureau data. The number living with parents grew to 26.6 million, an increase of 2.6 million from February. The number and share of young adults living with their parents grew across the board for all major racial and ethnic groups, men and women, and metropolitan and rural residents, as well as in all four main census regions. Growth was sharpest for the youngest adults (ages 18 to 24) and for White young adults.

A majority of young adults in the U.S. live with their parents for the first time since the Great Depression — https://pewrsr.ch/351SVs1

And to think the number of young people living with their parents was based upon data from July. This percentage will go higher since a lot of kids are moving back home from college earlier than expected.

The problem with college during the coronavirus pandemic is not just what’s happening on campuses and in college towns. It’s also that colleges may end up spreading the virus to dozens of other communities. In recent weeks, as students have returned to campus, thousands have become infected. And some colleges have responded by sending students home, including those known to have the virus.

Last week, after hundreds of students came down with the virus, the State University of New York at Oneonta ended in-person classes and sent students home. Colorado College, North Carolina State, James Madison (in Virginia) and Chico State (in California) have taken similar steps. At Illinois State, Georgia Tech and the University of Georgia, administrators have encouraged some students who have tested positive to leave campus, so they don’t infect other students, and return home.

These decisions to scatter students — rather than quarantine them on campus — have led to widespread criticism. “It’s the worst thing you could do,” Dr. Anthony Fauci, the federal government’s leading infectious-disease expert, said on NBC. “When you send them home, particularly when you’re dealing with a university where people come from multiple different locations, you could be seeding the different places with infection.” – Zach Morin, a University of Georgia student, told WXIA, a local television station, “Once it is open and people are there and spreading it, it doesn’t make sense to send it across the nation.” Susan Dynarski, a University of Michigan economist, wrote on Twitter that “unloading students onto home communities” was “deeply unethical.”

There are no easy answers for colleges, because creating on-campus quarantines brings its own challenges. At the University of North Carolina in Chapel Hill, one student who tested positive — Brianna Hayes — said that no employee checked on her during her week in isolation. “Feverish and exhausted from the virus, she made four trips up and down staircases to move her bedding and other belongings to her isolation room,” The Times’s Natasha Singer writes, in a story about campus quarantines.

Still, many experts say that the colleges that chose to reopen their campuses despite the risks, often for financial reasons, have a moral responsibility to do better. “Universities are not taking responsibility for the risks they are creating,” Sarah Cobey, an epidemiologist at the University of Chicago, said.

Last spring, the meatpacking industry became a vector for spreading the disease, when it quickly reopened and caused hundreds of new infections. This fall, higher education may end up being a similar vector.

David Leonhardt – The New York Times The Morning newsletter email 09.09.20

Clusterfuck.