Meat Intake and Colorectal Polyps

Meat Intake and Colorectal Polyps

Research professor of medicine Martha Shrubsole, Ph.D., and colleagues at Vanderbilt University Medical Center have published the first study to evaluate intakes of meat, cooking methods and meat mutagens and risk of developing sessile serrated polyps (SSPs, also called sessile serrated lesions). Shrubsole previously reported that consuming high levels of red meat increased the risk of developing all types of polyps, but that the likelihood of developing SSPs was two times greater than the risk of developing adenomas and hyperplastic polyps (HP).

Conventional colorectal adenomas are the precursor lesions for most colorectal cancers. SSPs, however, represent an alternative pathway to carcinogenesis that may account for up to 35 percent of colorectal cancers. Because a diagnostic consensus for SSPs was not reached until 2010, few epidemiologic studies have evaluated risk factors.

 

Gut Check! Two Mediterranean Diet Studies

In conclusion, these two outstanding studies support the fact that (1) it is not the quantity of calories per se that matters but the quality of the diet and (2) even in subjects of advanced age, adherence to a MedDiet is rapidly associated with different metabolic effects and reduced disease risk factors.

Mediterranean diet, gut microbiota and health: when age and calories do not add up!

 

Visceral fat delivers signal to the brain that hurts cognition

“We have identified a specific signal that is generated in visceral fat, released into the blood that gets through the blood brain barrier and into the brain where it activates microglia and impairs cognition.”

Visceral fat delivers signal to the brain that hurts cognition

Quote and article link presented without the usual sarcasm.

Molecule found in oranges could reduce obesity and prevent heart disease and diabetes

In mice, so don’t start gorging on oranges.

Sorry, sarcasm restriction didn’t last long.

Early studies on the diet suggested red wine was a major contributor to the health benefits of the Mediterranean diet because it contains a compound called resveratrol, which activated a certain pathway in cells known to increase lifespan and prevent aging-related diseases. However, work in Mashek’s lab suggests that it is the fat in olive oil, another component of the Mediterranean diet, that is actually activating this pathway.

Olive oil in the diet may also help mitigate aging-related diseases

 

Taco Bell is launching an all-vegetarian menu feature with 50 meat-free items

Taco Bell is launching an all-vegetarian menu feature with 50 meat-free items

I’ve been following the Vegan Tsunami for some time now.  See here, here, and here, 2018-The year vegan junk food went mainstream.

A few things to remember:

  • The media is extremely loud on this subject and the percentage of vegetarians in the United States is approximately 5% or less.
  • Fast food is still fast food, meat or no meat.
  • My post is not an endorsement.

I haven’t eaten at a Taco Hell in years.  And the availability of 50 meat free items is not going to entice me to start eating there again.  If you’re eating less meat for health reasons that’s fine.  But don’t pursue your meat-free lifestyle with fast food.

 

 

Alcohol consumption in later life and reaching longevity: the Netherlands Cohort Study

Key points

  • The highest probability of reaching 90 years of age (longevity) was found for men and women drinking 5– < 15 g alcohol/day (or 0.5–1.5 glass/day); the exposure–response relationship was significantly non-linear in women.
  • Usual drinking pattern and binge drinking were not significantly associated with longevity, but the risk estimates indicate to avoid binge drinking.
  • The estimated modest risk ratios (RRs) should not be used as motivation to start drinking if one does not drink alcoholic beverages.
Results

 

We found statistically significant positive associations between baseline alcohol intake and the probability of reaching 90 years in both men and women. Overall, the highest probability of reaching 90 was found in those consuming 5– < 15 g/d alcohol, with RR = 1.36 (95% CI, 1.20–1.55) when compared with abstainers. The exposure-response relationship was significantly non-linear in women, but not in men. Wine intake was positively associated with longevity (notably in women), whereas liquor was positively associated with longevity in men and inversely in women. Binge drinking pointed towards an inverse relationship with longevity. Alcohol intake was associated with longevity in those without and with a history of selected diseases.

 

Alcohol consumption in later life and reaching longevity: the Netherlands Cohort Study

Hormesis?

High-protein diets boost artery-clogging plaque

High-protein diets boost artery-clogging plaque, mouse study shows

In mice.

The mice on the high-fat, high-protein diet developed worse atherosclerosis — about 30% more plaque in the arteries — than mice on the high-fat, normal-protein diet, despite the fact that the mice eating more protein did not gain weight, unlike the mice on the high-fat, normal-protein diet.

“This study is not the first to show a telltale increase in plaque with high-protein diets, but it offers a deeper understanding of the impact of high protein with the detailed analysis of the plaques,” Razani said. “In other words, our study shows how and why dietary protein leads to the development of unstable plaques.”