How To Reduce Your DM2 Risk 31%

The results, published in Annals of Internal Medicine, were based on 4,746 adults between ages 55 and 75. All had overweight or obesity and metabolic syndrome, but none had diabetes or cardiovascular disease at the start of the study. Researchers followed participants for six years to see whether a more intensive Mediterranean based lifestyle plan could offer stronger protection against type 2 diabetes than the traditional Mediterranean diet alone.

One group followed a calorie reduced Mediterranean diet (about 600 kcal fewer per day), added moderate physical activity (brisk walking, strength and balance training), and received professional guidance. The comparison group followed a traditional Mediterranean diet without calorie restriction or exercise advice.

The difference between the two approaches was striking. Participants in the intervention group were 31% less likely to develop type 2 diabetes than those in the comparison group. Universidad de Navarra. “Scientists found a smarter Mediterranean diet that slashes diabetes risk by 31%.” ScienceDaily. https://www.sciencedaily.com/releases/2026/05/260519003103.htm (accessed May 23, 2026).

I just had my annual wellness check and got my lab results. All good except my fasting glucose.

Yikes. Memo to Self, get an A1C. Well, the very next day…

Doc says:

CMP (Comprehensive Metabolic Panel): Your creatinine (a measure related to kidney function) is low, and your blood sugar (glucose) is high; all other values are normal. This test checks how your kidneys and liver are working, your body salts, proteins, and blood sugar. Low creatinine can happen in people with less muscle and may be expected. The slightly high fasting blood sugar could indicate early changes in how your body handles sugar. Options include repeating the blood sugar test next visit.

I know my diet could be better. I know I should eat less, snack less and maybe, just maybe stop drinking beer. But also knowing my IFG is worsening I wondered if there was a diet (besides MedDiet) for IFG?

In recent years, low-calorie diets ranging from 800–1500 kcal/day have gained significant attention in managing type 2 diabetes8,1619. Studies have shown that low-calorie diets can lead to remission and substantial improvements in cardiometabolic risk factors for a significant proportion of individuals with type 2 diabetes8,1619. These diets are generally well-tolerated and safe, with only mild side effects reported. Table 1 summarizes the key low-calorie diet studies conducted in people with type 2 diabetes8,1619. Studies implementing low-calorie diets over a 2–5 month period, primarily high in protein and low in fat, have resulted in a mean weight loss of 7–15 kg (8–15% of initial body weight). This level of weight loss was accompanied by a notable reduction in hepatic fat and improved hepatic insulin sensitivity and first-phase insulin secretion. As a result, fasting plasma glucose levels decreased significantly by 27.8 to 43.2 mg/dL. This suggests that low-calorie diets may also be effective for individuals with i-IFG, as they target the pathophysiological defects characterizing this prediabetes phenotype8,1619. Figure 1 visually depicts the potential reversal of the twin cycle hypothesis through low-calorie diets in individuals with i-IFG. The twin cycle hypothesis20 postulates that chronic excess calorie intake results in increased accumulation of fat in the liver, leading to resistance against insulin’s suppression of hepatic glucose production. Additionally, excess liver fat increases lipid transportation to the pancreas, impairing β-cell function and further promoting hepatic glucose production. These self-reinforcing cycles between the liver and pancreas ultimately result  in the onset of hyperglycemia.

Low-calorie diets for people with isolated impaired fasting glucose – Commun Med (Lond) . 2024 Mar 1;4:35. doi: 10.1038/s43856-024-00466-2

The Plan

  • Eat less
  • Move more
  • Drink less beer

I like to keep things simple.

Neurodegenerative Copathology

About 20 years ago, neuropathologists began to report an inconvenient finding in the autopsied brains of people with dementia: Most have evidence of more than one disease. Studies since have shown the brains of up to half of people diagnosed with Alzheimer’s disease also have a key feature of Parkinson’s disease—deposits of the protein alpha synuclein. At the same time, up to half of Parkinson’s patients who develop dementia have elevated levels of beta amyloid and tau proteins, hallmarks of Alzheimer’s. Most dementia patients have multiple brain diseaseshttps://www.science.org/content/article/most-dementia-patients-have-multiple-brain-diseases-how-should-they-be-treated

Yikes.

The Nutritional Challenges of Advanced Age

The study focused exclusively on adults 80 and older, a group with very different dietary requirements than younger adults. As people age, the body goes through significant physiological changes. Energy expenditure decreases, and losses in muscle mass, bone density, and appetite are common. Together, these changes increase the risk of malnutrition and frailty.

Most evidence for the health benefits of diets that exclude meat comes from studies of younger adults rather than frail older populations. Some research suggests older non-meat eaters face a higher risk of fractures due to lower calcium and protein intake.

In later life, nutritional priorities shift. Rather than focusing on preventing long-term diseases, the goal becomes maintaining muscle mass, preventing weight loss and ensuring every mouthful delivers plenty of nutrients. Study finds vegetarians over 80 less likely to reach 100 -The Conversation. https://www.sciencedaily.com/releases/2026/02/260225081214.htm “Study finds vegetarians over 80 less likely to reach 100.” ScienceDaily. (accessed February 27, 2026).

Story Source:

Materials provided by The Conversation. Original written by Chloe Casey, Lecturer in Nutrition and Behaviour, Bournemouth University. Note: Content may be edited for style and length.

Coffee and Atrial Fibrillation

At the end of the study, the group that drank coffee experienced a 39% lower risk of recurring AFib episodes. In addition to coffee’s potential anti-inflammatory effects, the researchers proposed that those who drank coffee may have naturally replaced less healthy drinks, such as sugary sodas, with coffee instead. University of California – San Francisco. “Surprising heart study finds daily coffee may cut AFib risk by 39%.” ScienceDaily. http://www.sciencedaily.com/releases/2025/11/251110021046.htm (accessed November 10, 2025).

Journal Reference: Christopher X. Wong, Christopher C. Cheung, Gabrielle Montenegro, Hannah H. Oo, Isabella J. Peña, Janet J. Tang, Samuel J. Tu, Grace Wall, Thomas A. Dewland, Joshua D. Moss, Edward P. Gerstenfeld, Zian H. Tseng, Henry H. Hsia, Randall J. Lee, Jeffrey E. Olgin, Vasanth Vedantham, Melvin M. Scheinman, Catherine Lee, Prashanthan Sanders, Gregory M. Marcus. Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation. JAMA, 2025; DOI: 10.1001/jama.2025.21056

How To Reduce Your Risk of Developing Diabetes

The researchers, from 23 universities in Spain and Harvard Chan School, split 4,746 PREDIMED-Plus participants into an intervention group and a control group and followed their health outcomes for six years. The intervention group adhered to a Mediterranean diet; reduced their caloric intake by about 600 calories per day; engaged in moderate physical activity, such as brisk walking and strength and balance exercises; and received professional support for weight loss control. The control group adhered to a Mediterranean diet without calorie restriction, exercise guidance, or professional support. Participants ranged from age 55 to 75, were overweight or obese, and had metabolic syndrome, but were free of T2D at baseline.

The study found that those in the intervention group had a 31% lower risk of developing T2D compared to those in the control group. Additionally, the intervention group lost an average of 3.3 kilograms and reduced their waist circumference by 3.6 centimeters, compared to 0.6 kilograms and 0.3 centimeters in the control group. Scientists found 3 simple tweaks that cut diabetes risk by 31%https://www.sciencedaily.com/releases/2025/08/250829022835.htm Harvard T.H. Chan School of Public Health. ScienceDaily. http://www.sciencedaily.com/releases/2025/08/250829022835.htm (accessed August 29, 2025).

Guess I’ll cut out beer.

Thinking Styles – What’s Your Style?

Read this thinking style pyramid and refer back to it as often as needed.

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We are all suckers for click bait. I started with this:

Older Adults Face Higher Cancer Risk From Alcohol, Even at Low or Moderate Levelshttps://www.medscape.com/viewarticle/older-adults-face-higher-cancer-risk-alcohol-even-low-or-2025a

Scary stuff if you’re an older adult! I should STOP DRINKING ALCOHOL.

But what if this study is wrong? See pyramid above. Sensing bias in the article I took a look at the comments. Dr. Bradley Fawkes’ comment was noteworthy. In the results section of the study you’ll find this:

“While no associations were found for low- or moderate-risk drinking patterns vs occasional drinking among individuals without socioeconomic or health-related risk factors…” Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors – https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822215

So in the absence of socioeconomic or health-related risk factors no associations were found.

Cheers!

Obesity is Not a Disease

David L. Katz, MD, MPH, FACPM, FACP, FACLM is a specialist in Internal Medicine, Preventive Medicine/Public Health, and Lifestyle Medicine – globally recognized for expertise in chronic disease prevention, health promotion, and nutrition. The founding director of Yale University’s Prevention Research Center, and past president of the American College of Lifestyle Medicine, Katz is the founder of the non-profit True Health Initiative, founder of Diet ID, and Chief Medical Officer for leading food-as-medicine company, Tangelo. He is a senior science advisor to Blue Zones. He holds multiple US patents, including for advances in dietary assessment. He has roughly 250 peer-reviewed publications, has authored 19 books- including multiple editions of a leading textbooks in nutrition and preventive medicine, and has earned numerous awards for his contributions to public health, including three honorary doctoral degrees.

https://www.vumedi.com/video/obesity-is-not-a-disease-so-what-is-it

Diet until proven otherwise.

Diet and Healthy Aging

In the journal Nature Medicine this week there was an important open-access publication about a large combined cohort of over 105,000 health professionals prospectively followed for 30 years. Only 9.3% reached the age of 70 years with “healthy aging” —without 11 major chronic diseases and no impairment of cognitive or physical function or mental health. Our Diet and Healthy Aging Eric Topol, MD – https://erictopol.substack.com/p/our-diet-and-healthy-aging

Dr. Eric Topol’s assessment of this study is well balanced and thoughtfully written. His bio is here: https://www.scripps.edu/faculty/topol/

Healthy aging in this study is described as reaching age 70 without developing any of 11 major diseases: cancer (except for non-melanoma skin cancers), diabetes, heart attack, coronary artery disease, congestive heart failure, stroke, kidney failure, chronic obstructive pulmonary disease, Parkinson disease, multiple sclerosis and amyotrophic lateral sclerosis.

My Half-Birthday is coming up soon. I’ll be 70.5 years young. The biggest take home lesson for me is this:

Beer is better for you than pizza.