A Patent-Free Covid Vaccine for the World

While Big Pharma corporations took billions of dollars in public funding to help develop vaccines from which they then reaped enormous profits while often charging exorbitant prices, Hotez and Battazzi created Cobervax with $7 million, mostly from private investors. One of these, Austin vodka distiller Tito’s, contributed $1 million to the effort.

Texas Team Applauded for Giving What Big Pharma Refuses: A Patent-Free Vaccine to the World — https://www.commondreams.org/news/2021/12/30/texas-team-applauded-giving-what-big-pharma-refuses-patent-free-vaccine-world

And for whatever reason everyone seems to be out of stock for an at home rapid Covid-19 antigen test.

If I drank vodka I would only buy Tito’s for the rest of my life.

Are You Still Thinking About a Booster Shot?

What worries me is that what we now know in the United States is even if you’ve been vaccinated against Covid, you can incubate and replicate these variants, or even perhaps the native virus, in your nose, because we have incomplete immunity in the nose in someone who’s been vaccinated fully against Covid.

Corey Casper is the CEO of the Infectious Disease Research Institute and a professor of medicine and global health at the University of Washington.

The science behind booster shots – https://www.opb.org/article/2021/08/24/the-science-behind-booster-shots/

Experts say “waning immunity” is concerning, but it isn’t as scary as it sounds. The vaccines still work, and for most people, still provide a high level of protection against severe disease. “It’s been a challenge,” says Mark Slifka, an immunologist at Oregon Health and Science University. “because some people will say, ‘well the vaccines aren’t working.’ And that’s a misconception. Vaccines are still providing 90 percent protection against mortality and hospitalization.” Breakthrough infections have increased but infections are still three times more likely in unvaccinated than vaccinated individuals. Of those infections, only 3.9 percent have led to hospitalization in vaccinated patients compared to 9 percent in those who remain unvaccinated.

Six Questions About Waning Immunity to Covid-19 Answered — https://www.smithsonianmag.com/science-nature/six-questions-about-waning-immunity-to-covid-19-answered-180979135/

No political agenda here, no conspiracy theories. I’m just sharing some informative articles and hope you find them helpful as you navigate the Never Ending Pandemic.

Still Thinking About a Booster Shot?

When someone who has had a mild case of COVID is vaccinated, the antibody level in their blood doubles compared to an unvaccinated person who has been infected by the virus. Their antibodies are also better able to prevent spike-ACE-2 interaction.

Université de Montréal. “COVID-19: The older you are, the more antibodies you have, study finds.” ScienceDaily. http://www.sciencedaily.com/releases/2021/11/211108081455.htm (accessed November 9, 2021).

A very small study with very interesting findings.

Also see Thinking About a Booster Shot?

Thinking About a Booster Shot?

Waning Immunity after the BNT162b2 Vaccine in Israel – https://www.nejm.org/doi/full/10.1056/NEJMoa2114228?af=R&rss=currentIssue

The graph shows increases in the numbers of daily severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and new cases of severe coronavirus disease 2019 (Covid-19), on different scales, during the delta variant wave among persons who had received two doses of vaccine.

Waning Immunity after the BNT162b2 Vaccine in Israel – https://www.nejm.org/doi/full/10.1056/NEJMoa2114228?af=R&rss=currentIssue

It may be real nerdy but I like to do my research.

Molnupiravir 3.0

This post is updated to include a link to the http://www.nature.com article on this drug’s development history.

A planned interim analysis of 775 patients in Merck’s study found that 7.3% of those given molnupiravir were either hospitalized or had died by 29 days after treatment, compared with 14.1% of placebo patients. There were no deaths in the molnupiravir group, but there were eight deaths of placebo patients.

Merck to Seek FDA OK for Its COVID Pill After Trial Stopped Earlyhttps://www.medscape.com/viewarticle/960089?src=rss#vp_2

What we know — and don’t know — about Merck’s new Covid-19 pill

https://www.statnews.com/2021/10/04/what-we-know-and-dont-know-about-mercks-new-covid-19-pill/?utm_campaign=rss

Molnupiravir, on the other hand, gets incorporated into burgeoning RNA strands and, once inside, wreaks havoc. The compound can shift its configuration, sometimes mimicking the nucleoside cytidine and sometimes mimicking uridine. Those RNA strands become faulty blueprints for the next round of viral genomes. Anywhere the compound gets inserted and that conformational shift happens, a point mutation occurs, Plemper says. When enough mutations accumulate, the viral population collapses. “That is what we term lethal mutagenesis,” he adds. “The virus essentially mutates itself to death.” And because the mutations accumulate randomly, it’s difficult for viruses to evolve resistance to molnupiravir — another plus for the compound. But the compound’s mutagenic potential in human cells — the possibility that it could incorporate itself into DNA — does raise safety concerns, some researchers say.

How antiviral pill molnupiravir shot ahead in the COVID drug hunt — https://www.nature.com/articles/d41586-021-02783-1

Molnupiravir 2.0

A planned interim analysis of 775 patients in Merck’s study found that 7.3% of those given molnupiravir were either hospitalized or had died by 29 days after treatment, compared with 14.1% of placebo patients. There were no deaths in the molnupiravir group, but there were eight deaths of placebo patients.

Merck to Seek FDA OK for Its COVID Pill After Trial Stopped Earlyhttps://www.medscape.com/viewarticle/960089?src=rss#vp_2

What we know — and don’t know — about Merck’s new Covid-19 pill

https://www.statnews.com/2021/10/04/what-we-know-and-dont-know-about-mercks-new-covid-19-pill/?utm_campaign=rss

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

Twitter thread above. Link to the preprint study here:

https://www.biorxiv.org/content/10.1101/2021.08.23.457229v1

Is the race to reach herd immunity like chasing a mirage? — Science Chronicle

The emergence of highly contagious new variants, breakthrough infections even among the fully vaccinated and such people spreading the virus to others, and reinfections in the unvaccinated have made the race to reach the magical herd immunity threshold to successfully break the transmission chain and return to normal times looks like chasing a mirage. In […]

Is the race to reach herd immunity like chasing a mirage? — Science Chronicle

I Just Had my WOW Moment of the Weekend

WOW!

Protective heterologous T cell immunity in COVID-19 induced by the trivalent Measles-Mumps-Rubella and Tetanus-Diptheria-Pertussis vaccine antigens — Published:August 13, 2021DOI:https://doi.org/10.1016/j.medj.2021.08.004

There is a downloadable PDF of the study at the link above. Most of the terminology and research methodology is WAY above my pay grade but the conclusion is still a WOW.