Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort

Conclusion All NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.

Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort — https://gut.bmj.com/content/70/7/1375?rss=1

Also see previous posts:

NAFLD – Why are Life Insurers Taking This Risk at Standard Rates?

NAFLD

NAFLD and Obesity: What Is the Mortality Risk? | Medpage Today

NAFLD = Higher Mortality Rate

The Saddest Covid-19 Statistic

“For those of us in public health, it’s nothing short of amazing,” Dr. Jeff Duchin, the chief health officer for Seattle and King County, told me the other day. I had called Duchin to ask about a startling claim he made recently. At a weekly health briefing, he offhandedly remarked that of King County’s recent COVID-19 cases, 97% had occurred in unvaccinated people. It effectively meant the only people still catching coronavirus here in King County are people who haven’t gotten the shots. It also means the disease that just a few months ago threatened the entire nation is now almost exclusively circulating among a shrinking few.

“We’re getting to the point where it’s a tale of two societies,” says Dr. Umair Shah, the state health secretary.Shah reported this past week that unvaccinated people between ages 45 and 64 are now being hospitalized for COVID at rates 21 times higher than the vaccinated.

The ‘two societies’: 97% of new COVID cases are among people who haven’t gotten the shots — https://www.seattletimes.com/seattle-news/health/the-two-societies-97-of-new-covid-cases-are-among-people-who-havent-gotten-the-shots/#comments

At the Seattle Times website for this article you’ll find over 500 comments. After reading several comments I had to stop. Every comment I read made me sad about all of the things we have gotten wrong during the pandemic. One of the worst things that has happened was the politicization of Covid-19. Sometimes I just wish it would stop.

If for whatever reason you choose to refuse the vaccine I have no interest in debating your decision. I’ll present some facts and we can remain cordial.

More Retirement Income Ahead!

Total individual life insurance policy sales increased 11% in the first quarter, compared with first quarter 2020. This is the highest growth in the number of policies sold in a quarter since 1983. New annualized premium also experienced significant growth, up 15% from prior year, according to LIMRA’s First Quarter U.S. Individual Life Insurance Sales Survey.

LIMRA: First Quarter U.S. Life Insurance Policy Sales Highest Since 1983 — https://www.limra.com/en/newsroom/news-releases/2021/limra-first-quarter-u.s.-life-insurance-policy-sales-highest-since-1983/

I don’t know who you are. I don’t know what you want. If you are looking for ransom, I can tell you I don’t have money. But what I do have are a very particular set of skills; skills I have acquired over a very long career. Skills that make me a nightmare for people like you.

Bryan Mills, played by Liam Neeson in the film Taken

I had my annual wellness visit earlier this week.

5.10 168 130/84 BMI 24.14 O2 sat 98%

CHOLESTEROL 175 mg/dL
TRIGLYCERIDE 69 mg/dL
HDL 65 mg/dL
LDL CALCULATED 96 mg/dL
NON-HDL CHOLESTEROL 110 mg/dL

All of my other labs were normal too.

I have multiple relatives who have lived well into their 90’s. My maternal grandmother lived to 100. I’m going to need another source of retirement income. And for all of my friends and colleagues who never thought I would make it this far…

AST 23 U/L

ALT 7 U/L

GGT 36 U/L (12/2015)

PSA 0.7 (9/2020)

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

Memo to Owners of Original Content

I have been to your website and read your Terms of Use. I understand you have granted me you a limited, personal, revocable, non-exclusive, and non-transferable license to use your Services for my personal, non-commercial use only and can print or download pieces of the Content for my personal and non-commercial use.

Now that we have gotten that out of the way…

“Last fall, there were reports that antibodies wane quickly after infection with SARS-CoV-2, and mainstream media interpreted that to mean that immunity was not long-lived,” said senior author Ali Ellebedy, PhD, Washington University School of Medicine, St. Louis, Missouri. “But that’s a misinterpretation of the data. It’s normal for antibody levels to go down after acute infection, but they don’t go down to zero — they plateau. Here, we found antibody-producing cells in people 11 months after first symptoms. These cells will live and produce antibodies for the rest of people’s lives. That’s strong evidence for long-lasting immunity.”

Mild COVID-19 Induces Lasting Antibody Protection — https://ntk-institute.org/article/mild-covid-19-induces-lasting-antibody-protection

Here’s the link to the original research article abstract:

Turner, J.S., Kim, W., Kalaidina, E. et al. SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans. Nature (2021). https://doi.org/10.1038/s41586-021-03647-4

Obvious but not Proven – PCOS and Covid-19

Roach’s and Gotluru’s research, published in the March issue of the journal Obstetrics and Gynecology, shows the potentially higher risk for PCOS patients comes down to “comorbidities, androgens and lipotoxicity.

“People with PCOS often have higher levels of and sensitivity to androgens, male sex hormones. This could “potentially directly affect the susceptibility to COVID-19,” Roach and Gotluru wrote. Androgens work as a “gateway,” in very simple terms, to let in Covid-19, Roach says.

https://www.cnn.com/2021/05/23/health/women-covid-pcos-high-risk/index.html — The women possibly at higher risk for Covid-19 that no one is talking about

Many thanks to Ol Red Hair for directing my attention to this article.

The Bottom Line – Got PCOS? Get vaccinated.

Type 2 Diabetes Risk and…Sardines?

Older people with prediabetes who followed a diet rich in sardines for 1 year show significant reductions in risk of developing type 2 diabetes compared with those placed on a similarly healthy diet but without the sardines, results from a new randomized trial show.

 “A 1-year, sardine-enriched type 2 diabetes-preventive diet in an elderly population with prediabetes exerts a greater protective effect against developing type 2 diabetes and cardiovascular events, by improving anthropometric parameters, blood chemistry profile, lipid composition in erythrocytes membranes, and metabolomics data,” report the authors in research published in Clinical Nutrition by Diana Díaz-Rizzolo, PhD, of the Hospital Clinic of Barcelona, Spain, and colleagues.

Sardines Linked to Reduced Type 2 Diabetes Risk — https://www.medscape.com/viewarticle/951528?src=rss#vp_1

Very small study with very interesting findings.

If I only liked sardines.

New Source For Jet Fuel



Researchers have developed an innovative way to convert plastics to ingredients for jet fuel and other valuable products, making it easier and more cost effective to reuse plastics. The researchers in their reaction were able to convert 90% of plastic to jet fuel and other valuable hydrocarbon products within an hour at moderate temperatures and to easily fine-tune the process to create the products that they want.

Washington State University. “New technology converts waste plastics to jet fuel in an hour.” ScienceDaily. http://www.sciencedaily.com/releases/2021/05/210517124937.htm (accessed May 18, 2021).

Yeah I know this has absolutely nothing to do with mortality risk but it was SO COOL I had to post it.

PPI’s and Gastric Cancer Risk

Objective The association between proton pump inhibitor (PPI) use and gastric cancer related to Helicobacter pylori eradication has not been fully investigated in geographical regions with high risk of gastric cancer. We aimed to evaluate the association between PPIs and gastric cancer in Korea.

Design This study analysed the original and common data model versions of the Korean National Health Insurance Service database from 2002 to 2013. We compared the incidence rates of gastric cancer after 1-year drug exposure, between new users of PPIs and other drugs excluding PPIs, by Cox proportional hazards model. We also analysed the incidence of gastric cancer among PPI users after H. pylori eradication.

Results The analysis included 11 741 patients in matched PPI and non-PPI cohorts after large-scale propensity score matching. During a median follow-up of 4.3 years, PPI use was associated with a 2.37-fold increased incidence of gastric cancer (PPI≥30 days vs non-PPI; 118/51 813 person-years vs 40/49 729 person-years; HR 2.37, 95% CI 1.56 to 3.68, p=0.001). The incidence rates of gastric cancer showed an increasing trend parallel to the duration of PPI use. In H. pylori-eradicated subjects, the incidence of gastric cancer was significantly associated with PPI use over 180 days compared with the non-PPI group (PPI≥180 days vs non-PPI; 30/12 470 person-years vs 9/7814 person-years; HR 2.22, 95% CI 1.05 to 4.67, p=0.036).

Conclusion PPI use was associated with gastric cancer, regardless of H. pylori eradication status. Long-term PPIs should be used with caution in high-risk regions for gastric cancer.

Association between proton pump inhibitor use and gastric cancer: a population-based cohort study using two different types of nationwide databases in Korea — https://gut.bmj.com/content/early/2021/05/11/gutjnl-2020-323845?rss=1
  • Prevacid 24HR
  • Nexium 24HR
  • Prilosec OTC
  • Zegerid OTC

OTC PPIs are only intended for a 14-day course of treatment and can be used up to three times per year.

Over-The-Counter (OTC) Heartburn Treatment — https://www.fda.gov/drugs/information-consumers-and-patients-drugs/over-counter-otc-heartburn-treatment

I was thinking of a snarky comment but decided against posting any snark.

But if you routinely pop a PPI before and/or after chowing down on a meat lover’s pizza you can’t say you weren’t advised that maybe it might be a better idea to give up the pizza.