Optimize This!

But the productivity gurus were child’s play compared to the rise of the biohacking movement that followed. Guys like Andrew Huberman and Bryan Johnson rose to fame in recent years with their strict diets, excessive supplementation, and elaborate morning routines. Science-backed exercise and nutrition advice became the name of the game. And there was no shortage of influencers to supply it. Optimizing Ourselves to Deathhttps://ofdollarsanddata.com/optimizing-ourselves-to-death/

You can’t optimize everything. Mistakes will be made and are part of life. Sub-optimal for whatever you are chasing will be the end result because perfection is impossible.

Tell yourself this is OK.

Peptides Explained

Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls.

The people currently using these compounds are, in effect, running an uncontrolled experiment on themselves. Peptides, explained: Answers to your top questionshttps://yourlocalepidemiologist.substack.com/p/peptides-explained-answers-to-your?

An uncontrolled experiment on themselves.

Yikes.

Neurodegenerative Copathology

About 20 years ago, neuropathologists began to report an inconvenient finding in the autopsied brains of people with dementia: Most have evidence of more than one disease. Studies since have shown the brains of up to half of people diagnosed with Alzheimer’s disease also have a key feature of Parkinson’s disease—deposits of the protein alpha synuclein. At the same time, up to half of Parkinson’s patients who develop dementia have elevated levels of beta amyloid and tau proteins, hallmarks of Alzheimer’s. Most dementia patients have multiple brain diseaseshttps://www.science.org/content/article/most-dementia-patients-have-multiple-brain-diseases-how-should-they-be-treated

Yikes.

Alarmingly Shallow Ideas

As one New York financier told Financial Times journalist Gillian Tett, new hires who were seen as “AI natives” are turning out to have alarmingly shallow ideas. So much so, the anonymous finance worker admitted, that his firm now actively avoids seeking out AI-literate STEM graduates, and opts to comb through humanities students instead…

The state of higher education is so bad that many of today’s higher ed students are not only offloading their coursework to AI chatbots like ChatGPT — a shortcut, educators say, that’s even impacting their ability to participate in face-to-face discussions. Bosses Horrified as “AI Native” College Graduates Hit the Workplacehttps://futurism.com/future-society/college-critical-thinking-ai

Yikes.

Deeply disturbing. So what can a concerned parent do?

Ask ChatGPT what to do!

My college graduate son has no critical thinking skills after relying upon ChatGPT. What should I do?

Treat this as a skills-and-habits problem, not a character flaw or a “ChatGPT ruined him” problem. A lot of recent graduates learned to use AI as a shortcut before they learned how to think through ambiguity on their own. The good news is that critical thinking is trainable.

A few things matter here:

  1. Don’t turn this into a fight about technology
  2. Separate competence from confidence
  3. Create situations where he has to reason, decide, and defend conclusions

What often happens is:

  • Students get very good at producing polished answers
  • But weak at:
    • evaluating evidence
    • making tradeoffs
    • spotting bad assumptions
    • persisting through confusion
    • forming independent judgment

Those are different skills.

Here’s what tends to work better than lectures about “kids relying on AI.”

Change how he uses AI

The goal is not “stop using ChatGPT.” It’s “use it as a sparring partner instead of a vending machine.”

Encourage rules like:

  • No copying answers directly
  • He must form an opinion first
  • He must explain why an answer is correct
  • He must ask AI to critique his reasoning instead of replacing it

Good prompts:

  • “Challenge my assumptions.”
  • “What are the strongest counterarguments?”
  • “What evidence would disprove this?”
  • “What am I overlooking?”
  • “Give me three competing interpretations.”

Bad pattern:

  • “Write this for me.”

Put him in environments that punish shallow thinking

Critical thinking develops fastest when reality pushes back.

Good environments:

  • Jobs with responsibility and consequences
  • Sales
  • Operations
  • Managing projects
  • Technical troubleshooting
  • Apprenticeships
  • Debate-heavy workplaces
  • Entrepreneurship
  • Volunteer leadership

Real-world feedback is hard to fake.

Ask questions instead of giving conclusions

If you immediately correct him, he stays mentally passive.

Instead ask:

  • “How did you arrive at that?”
  • “What evidence supports it?”
  • “What would change your mind?”
  • “What’s the downside of your approach?”
  • “What assumption are you making?”

That forces metacognition.

Make him defend positions he disagrees with

One of the fastest ways to build reasoning is:

  • argue both sides
  • compare tradeoffs
  • steelman opposing views

You can do this casually over dinner or current events.

Encourage slow thinking

A lot of AI-heavy habits create intellectual impatience.

Critical thinking often requires:

  • sitting with uncertainty
  • reading longer material
  • comparing sources
  • wrestling with incomplete information

Books, long-form journalism, analytical podcasts, and difficult projects help rebuild that stamina.

Watch for learned helplessness

Sometimes the issue is not inability but reflexive dependence:

  • “I don’t know immediately”
    → “I need AI to think for me”

A useful rule:

  • Spend 15–30 minutes thinking independently before asking AI.

Also be realistic about the transition to adulthood

Many graduates — long before AI existed — left college without strong judgment skills. Those usually develop through:

  • responsibility
  • mistakes
  • work
  • relationships
  • financial pressure
  • repeated decision-making

You do not need to panic because he’s behind in one area at graduation.

The biggest mistake parents make here is trying to “convince” an adult child that he lacks critical thinking. That usually triggers defensiveness and dependency at the same time.

A better posture is:

  • respect him as an adult
  • expect reasoning and accountability
  • ask probing questions
  • stop rescuing poor decisions too quickly
  • encourage environments that require independent judgment

If you want, I can also help you with:

  • signs that this is normal vs genuinely concerning
  • exercises that rebuild critical thinking quickly
  • how to talk to him without sounding accusatory
  • ways young professionals can use AI without weakening reasoning skills

Colorectal Cancer and Mortality Risk Among Older Adults

Conclusions and Relevance  Adults 75 years of age or older with adenoma at prior colonoscopy were more likely to experience subsequent CRC and CRC death compared with those without adenoma, but cumulative risks were low and were far exceeded by competing risks for non-CRC death. Older adults may consider deprioritizing surveillance colonoscopy relative to other health concerns. Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopyhttps://jamanetwork.com/journals/jama/article-abstract/2847311

(Less Than) Random Thoughts on Retirement – 05.03.26

Yes dear reader, yet another post in the never ending series of random thoughts on retirement. https://lifeunderwriter.net/tag/random-thoughts-on-retirement/

Though the traditional retirement age in the U.S. typically falls between 62 and 67, many Americans continue working beyond that point. As of 2024, slightly more than 22% of adults aged 65 and older are still employed, either full-time or part-time. Though the traditional retirement age in the U.S. typically falls between 62 and 67, many Americans continue working beyond that point. As of 2024, slightly more than 22% of adults aged 65 and older are still employed, either full-time or part-time.https://financebuzz.com/working-in-retirement-data

I’m not the only Old Guy who is still working past age 65.

But despite the fact I’m not the only Old Guy who is still working past age 65 more people are starting retirements earlier than they expected (always have a Plan B and maybe even a Plan C).

2026 EBRI/Greenwald Retirement Confidence Survey https://www.ebri.org/content/2026-ebri-greenwald-retirement-confidence-survey

I just learned I’m not the only Old Guy who still has a mortgage.

Over the past three decades, the share of homeowners ages 65 to 79 with a mortgage rose from 24% to 41%, while median mortgage debt surged by 400%, according to the Joint Center for Housing Studies at Harvard University. More Americans aging into retirement are still paying down mortgageshttps://www.marketplace.org/story/2025/06/09/more-older-americans-continue-to-pay-mortgages

I also learned about the disappearance of structured cognitive demand in retirement.

A 2025 systematic review published in Health Psychology Review found that retirement is associated with measurable cognitive decline, not just because people age, but because structured cognitive demand disappears. Researchers have called it “mental retirement”: The brain follows the body’s example and withdraws from challenge. Gary Has a Plan for Retirement: Crash on the Sofa and Veg. Here’s the Problem With That …https://www.kiplinger.com/retirement/retirement-planning/your-long-term-retirement-plan-needs-a-purpose

I’m now paranoid about the disappearance of structured cognitive demand with a mortgage to pay off and too scared to retire.

Incubation of Craving (in rats)

Changes in neural connections due to substance use and withdrawal are long-lasting, and craving can peak well into abstinence.

Incubation of craving in rats — in other words, an inverted U-shaped curve where craving rises, plateaus and then declines — holds across drug classes. So although it was initially demonstrated for cocaine, incubation of craving occurs in rats after self-administration of methamphetamine, opioids, nicotine and ethanol. Incubation of cue-induced craving has also been demonstrated in humans — so far, this has been shown during abstinence from cocaine, methamphetamine, nicotine and alcohol. So that long plateau phase that we see in the animals is a relevant model for the persistent vulnerability to craving and relapse in humans who are trying to recover from substance use disorder. What addiction does to the brainhttps://knowablemagazine.org/content/article/mind/2026/what-addiction-does-to-synapses-in-brain

The article is an interview with Marina Wolf, a behavioral neuroscientist at the Oregon Health & Science University. Good stuff if your brain is into brain stuff.

Medscape on Obesity – 04.26.26

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