POP !!!
I Stopped Drinking Alcohol Every Day (bonus Scary Chart)
Worldwide, MASLD became the most common chronic liver disease, affecting up to 38% of the adult population (11). In addition, the global prevalence of MASLD is expected to further increase during the next two decades (12). For example, in the U.S., the prevalence of MASLD is predicted to increase from 34% (86 million people) in 2020 to 41% (122 million people) by 2050 (13). MASLD is an increasingly important contributor not only to liver-related but also to extrahepatic morbidity and mortality worldwide. This observation supports that the clinical burden of MASLD clearly extends far beyond the liver, making it a multisystem disorder. While among people with MASLD <10% develop liver-related complications, the major causes of death are CVD and cancer (11,14).
Today, the highest global pooled prevalence of MASLD is found among people with obesity (75% [95% CI 71–79]) (15) and type 2 diabetes (65% [61–68]) (16). Among people with obesity (34% [28–39]) and people with diabetes (32% [17–51]) there is also a very high prevalence of the advanced form of MASLD, metabolic dysfunction–associated steatohepatitis (MASH) (15,16). Furthermore, at 37% (95% CI 26–48), the prevalence of MASLD is also very high among children and adolescents with type 2 diabetes (17). This very early onset of MASLD may have severe long-term consequences for the liver, such as higher risk for cirrhosis and hepatocellular carcinoma (HCC). In addition, among adults with prediabetes prevalence of MASLD is approximately twofold higher in comparison with people with normal glucose regulation, independently of adiposity (18). The findings that overweight and hyperglycemia are tightly related to MASLD indicate that there are joint pathomechanisms promoting adiposity, hyperglycemia, and MASLD. Furthermore, hyperglycemia may promote hepatic steatosis and inflammation, and the steatotic and inflamed liver may also be involved in the pathogenesis of type 2 diabetes. Thus, there may be a vicious cycle between increased liver fat content and insulin resistance–associated hyperglycemia promoting the progression of both diseases.
Norbert Stefan; MASLD as Complication of Diabetes. Diabetes 20 July 2026; 75 (8): 1359–1370. https://doi.org/10.2337/dbi26-0001
The US Health and Human Services (HHS) and Department of Agriculture (USDA) issued new alcohol guidelines in January 2026 “Consume less alcohol for better overall health” and I take advice from my government seriously.
Need. More. Steps.
Walking is the most preferred PA mode for older adults [4] and increasing daily step count may reduce the presence of frailty. Observational research finds a dose-response relationship with higher daily step counts associated with lower frailty prevalence [5]. This relationship persists even among those with very low step counts (less than 3,000 per day) suggesting any increase in step counts may reduce frailty presence. Step counts can be increased by walking for longer durations or walking faster for the same duration. Observed as the 6th vital sign, gait speed is a key frailty indicator, as slow gait speed is one of the most frequently observed and prevalent criteria of frailty [6]. Since gait speed predicts mortality, falls, loss of independence, and cognitive decline [7], and is an important clinical metric of overall health [8], interventions which improve capacity to ambulate faster and over longer distances (e.g., a greater volume of activity) may be particularly therapeutic for those with frailty…
This is the first study to demonstrate that HIW can reverse frailty in older adults with frailty. After 16 weeks, HIW participants had significantly higher odds of improving at least one SHARE-FI frailty category compared to CSW participants. Numerous prior studies have investigated physical activity, multicomponent training, resistance exercise, and nutrition3,9 to improve capacity and physical function, rather than directly modifying the frailty syndrome. In a systematic review of 26 PA intervention studies for frailty, only one study used an aerobic intervention, and this study did not measure frailty as a primary outcome. [25]. In studies that have used frailty as a primary outcome, minimal benefit has been found. Huang et. al, found a 0.02 reduction in frailty index after 26 weeks of training twice-weekly at 70% of heart rate reserve, which did not meet the 0.03 threshold for clinical meaningful change in frailty index scores [26,27]. The combination of aerobic and resistive aerobic activities in our approach may have provided sufficient neuromuscular stimulus by increasing frequency and intensity of activity, despite a shorter intervention duration, to drive improvements in frailty category. Our study advances evidence for the optimal dose of therapeutic interventions for the frailty and provides clear evidence on the substantial benefits of high-intensity walking to decrease and reverse frailty among those with existing frailty. Our approach, which incorporated some resistance elements into aerobic training, was distinct.
Citation: Danilovich M, Rubin DS, Conroy DE, Diaz L, Cheung Y, Corcos D, et al. (2026) A high intensity vs. casual speed walking intervention to reverse frailty among older adults: a cluster randomized controlled trial. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357605
But first, must get these Chinknees fixed.
PEth as a Diagnostic Biomarker for Identifying AUD
Prospective study of phosphatidylethanol (PEth) as a diagnostic biomarker for identifying alcohol use disorder (AUD) among participants at risk for steatotic liver disease – https://doi.org/10.1136/gutjnl-2026-339702
Cool.
Improve Your Child’s Academic Performance!
Phone ban impact on student academic achievement
The top estimate is the estimated average treatment effect of the phone ban on student academic achievement across the full population. The next estimates contain heterogeneous treatment effects for subgroups split by prior average academic achievement (above or below preexperiment median), years of study, and field of study.
Source: Alp Sungu et al.,Phones impede learning: Evidence from a massive phone-free classroom experiment.Science394,178-181(2026).DOI:10.1126/science.aef7249 https://www.science.org/doi/10.1126/science.aef7249
I’m Taking Your Phone Away (and you didn’t do anything wrong)
Wait…I need to check my phone.
Scary Charts – 10.06.26

The delinquency rate of office mortgages that have been securitized into commercial mortgage-backed securities (CMBS) re-spiked in recent months and in September hit 12.2%, the second highest ever, behind only January 2026 (12.3%), and 1.5 percentage point above the worst moments of the Financial Crisis, according to data by Trepp, which tracks and analyzes CMBS.
Source: Office CMBS Delinquency Rate Re-Spikes to 12.2%, Far Worse than Financial Crisis Peak. End of Extend-and-Pretend Looms https://wolfstreet.com/2026/10/05/office-cmbs-delinquency-rate-re-spikes-to-12-2-far-worse-than-financial-crisis-peak-as-end-of-extend-and-pretend-looms/
I was thinking about how bad the US economy really is behind the curtain.
I can’t believe the number of hockey stick charts I continue to find.
Improve Your Child’s Mental Health and Academic Performance!
Results This study included 5515 adolescent participants (2640 [47.9%] female; mean [SD] age 11.93 [0.65] years) using step counters. Higher step count was associated with lower total mental health problems (B [SE], −0.080 [0.015]; t = −5.497; P < .001) and greater cortical thickness in the paracentral (B [SE], 0.057 [0.016]; t = 3.621; P < .001) and rostral anterior cingulate (B[SE], 0.052 [0.016]; t = 3.319; P = .001) regions. Further analyses showed a significant dose-response association, with progressively lower mental health problems across higher step categories compared with the under 5000-step group. Mediation analyses revealed that greater paracentral thickness statistically mediated the association between higher daily step count and fewer mental health problems 1 year later.
Conclusions and Relevance In this cohort study, higher daily step counts were associated with structural differences in the brains of adolescents, which were in turn associated with better mental outcomes prospectively. Beneficial associations for mental health appeared to accrue continuously across the observed range, with no evidence of a threshold or plateau, highlighting that every step counts and the potential value of promoting daily steps in adolescents. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2854698
Li Q, Paluch A, Rakesh D. Physical Activity and Adolescent Brain Structure, Mental Health, and Academic Outcomes. JAMA Netw Open. 2026;9(10):e2636973. doi:10.1001/jamanetworkopen.2026.36973
Greater cortical thickness too!
WOOHOO.
Scary Charts – 09.25.26
De La Paz has $96 deducted from her paycheck every month for her employee lodging, which covers her bed in a dorm room she shares with up to two roommates, as well as Wi-Fi and utilities. Dorm living comes with a communal bathroom, laundry facilities, common areas and social events.
Source: She pays $96 a month to live in Yellowstone National Park: ‘Being here has changed my life’ – https://www.cnbc.com/2026/09/19/living-in-yellowstone-for-96-dollars-a-month.html
I was thinking about how to stretch our finances in retirement.
This creative young woman sews for a living.
My extremely significant other has a sewing machine…
Scary Charts – 09.24.26

It’s as simple as this: as long-term interest rates continue moving higher, virtually every important piece of financial math gets worse, all at the same time.
The discount rate used to value stocks rises, which makes future earnings worth less today. Mortgages get more expensive. Corporate borrowing gets more expensive. Private equity deals and private credit…much of which is already FUBAR but not showing it yet…become harder to finance. Leveraged companies have to refinance debt at higher rates. Consumers pay more to borrow and the federal government pays more to service its enormous pile of debt.
Yikes.
Stuck in Oklahoma
Cost of living continues to be one of the most powerful forces shaping where Americans choose to move. In 2025, the relationship between affordability and migration was especially clear: states that offered lower everyday expenses consistently attracted more new residents on a per-capita basis. Oklahoma, Mississippi, and West Virginia rank as the three least expensive states to live in, and all three landed within the top 15 states for net migration per 10,000 residents. Their performance reinforces the idea that when housing, utilities, and daily necessities remain accessible, people are far more willing to relocate. The 2026 HireAHelper Moving Migration Report – https://www.hireahelper.com/moving-statistics/migration-report/2026/

Best Big Cities to Live in the U.S. in 2026-2027 – https://realestate.usnews.com/places/rankings/best-large-cities
Midwest City Known as ‘Niceville USA’ Leads the Nation in Homebuilding and Affordability – https://www.realtor.com/news/trends/homebuilding-affordability-des-moines-iowa-2026-report-card/
I’m stuck here.






You must be logged in to post a comment.