I’ll Have the Metformin and Liraglutide Please

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After an average of four years of follow-up, the study found that participants taking metformin plus liraglutide or insulin glargine achieved and maintained their target blood levels for the longest time compared to sitagliptin or glimepiride. This translated into approximately six months more time with blood glucose levels in the target range compared with sitagliptin, which was the least effective in maintaining target levels. Treatment effects did not differ based on age, sex, race, or ethnicity.

However, none of the combinations overwhelmingly outperformed the others.

Two popular diabetes drugs outperformed others in large clinical trial — https://www.nih.gov/news-events/news-releases/two-popular-diabetes-drugs-outperformed-others-large-clinical-trial

BUT if you can Stay as Thin as You Can as Long as You Can maybe, just maybe you won’t develop DM2.

Quote for Today – 09.22.22

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Charlie Munger, the billionaire partner to Warren Buffett at Berkshire Hathaway, describes his friend’s day as 80 percent reading—often five hundred pages. Before he invests his client’s money in a company, Buffett puts the odds in his favor by reading everything he possibly can about the company itself and the broader industry. He is not always right, but he is always informed. We might imagine him flying around on private jets, wheeling and dealing, when in fact he is more likely sitting at his desk, reading everything from the great books to technical analysis.

Mr. Buffett’s reading habit provides a powerful lesson for all of us. But most Americans read almost nothing. A friend who teaches at a large public university thinks less than half of his incoming freshmen have ever read a single book in full.

Jeff Deist President of the Mises Institute. Five Keys to Professional and Personal Development accessed online 9/22/22 — https://mises.org/wire/five-keys-professional-and-personal-development

Some good advice, no matter what stage in life you find yourself. This talk was delivered on September 2, 2022, to a student workshop at the Ron Paul Institute conference in northern Virginia.

  1. Sift
  2. Read
  3. Learn Continuously
  4. Avoid Arguments
  5. Promote People, Not Just Ideas

Management Alert – Do Not Ignore This Survey

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A mere 6% want to work entirely on-site going forward. Doesn’t it seem that traditional management and workplace practices are broken if more than 90% of 70 million employees say they don’t want to come back to the office full time?

Returning to the Office: The Current, Preferred and Future State of Remote Work — https://www.gallup.com/workplace/397751/returning-office-current-preferred-future-state-remote-work.aspx

I work in a profession that is perfectly suited for WFH. I’ve worked from home since 2006. Aside from losing most of my social skills…

Another Sweet Saturday – 09.17.22

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Our 1-year RCT indicated that a lifestyle intervention program can be highly successful in older adults with diabetes and chronic comorbidities. In this specific population, lifestyle intervention not only improved glycemic control associated with improved insulin action and secretion but also improved age-relevant outcomes such as body composition, physical function, and quality of life.

Alessandra Celli, Yoann Barnouin, Bryan Jiang, Dean Blevins, Georgia Colleluori, Sanjay Mediwala, Reina Armamento-Villareal, Clifford Qualls, Dennis T. Villareal; Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial. Diabetes Care 1 September 2022; 45 (9): 1943–1952. https://doi.org/10.2337/dc22-0338

From the periods 1988–1994 to 2017 to March 2020, there was an increase in the prevalence of diagnosed diabetes (from 4.6% to 11.7%), but no change in prevalence of persistent undiagnosed diabetes (from 2.23% to 2.53%) or confirmed undiagnosed diabetes (from 1.10% to 1.23%). Consequently, the proportion of all undiagnosed diabetes cases declined from 32.8% to 17.8% (persistent undiagnosed diabetes) and from 19.3% to 9.5% (confirmed undiagnosed diabetes). Undiagnosed diabetes was more prevalent in older and obese adults, racial/ethnic minorities, and those without health care access. Among persons with diabetes, Asian Americans and those without health care access had the highest proportion of undiagnosed cases, with rates ranging from 23% to 61%.

Michael Fang, Dan Wang, Josef Coresh, Elizabeth Selvin; Undiagnosed Diabetes in U.S. Adults: Prevalence and Trends. Diabetes Care 1 September 2022; 45 (9): 1994–2002. https://doi.org/10.2337/dc22-0242

Remember, Stay as Thin as You Can as Long as You Can.

Covid and…Neti Pot?

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They knew that the more virus that was present in your body, the worse the impact, Baxter says. “One of our thoughts was: If we can rinse out some of the virus within 24 hours of them testing positive, then maybe we can lower the severity of that whole trajectory,” she says, including reducing the likelihood the virus could get into the lungs, where it was doing permanent, often lethal damage to many.

Medical College of Georgia at Augusta University. “Twice-daily nasal irrigation reduces COVID-related illness, death, study finds.” ScienceDaily. http://www.sciencedaily.com/releases/2022/09/220913110403.htm (accessed September 13, 2022).

Small study n=79 but still…

An Algorithm Put This Article in My News Feed

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Photo by Egor Kamelev on Pexels.com

In a survival situation, you probably wouldn’t make it on bugs alone, despite what some sites would have you believe. But insects could certainly be an important part of what keeps you alive. Bugs are highly nutritious, with lots of proteins and vitamins and modest amounts of fat. Here are the things you should know.

9 Bugs to Eat in a Survival Situation (And 4 You Want to Avoid) — https://www.fieldandstream.com/story/survival/insects-to-eat-in-survival-situation/

Faithful followers know I have two blogs, this one and http://garyskitchen.net. The latter is more or less devoted to food. I debated whether to post this article link here or there. I decided here because my professional life is devoted to understanding what kills people. Obviously getting lost while hiking and running out of food can lead to an early expiration date.

The article was fun to read. You’ll enjoy it too unless you’re a conspiracy theorist.

Insect consumption has been highlighted by the UN’s Food and Agriculture Organization as an important tool in addressing food insecurity for a growing global population. And since agriculture is the second-largest greenhouse gas emitter after the energy sector, insect eating presents a compelling climate solution, too – crickets, for example, can provide the same amount of protein as cows for less than 0.1% of the emissions.

Meaty, cheesy, coconutty: a chef’s quest to prove insects taste delicious — https://www.theguardian.com/environment/2022/sep/09/insects-food-menu?amp;amp;amp

Hmm…maybe I should have posted this on https://garyskitchen.net