New House Construction Supply Chain Mess

The inventory of new single-family houses that home builders put on the market for sale rose to 389,000 in October, the highest since September 2008, according to data from the Census Bureau.

Houses for Sale, Highest since 2008, as Construction Costs Spike Most in 42 Years, Projects Stall — https://wolfstreet.com/2021/11/27/whats-behind-the-huge-pile-up-of-new-houses-for-sale-highest-since-2008-as-construction-costs-spike-most-in-42-years-and-projects-stall
Does anyone else see a problem here?

Diet-induced Alteration of Intestinal Stem Cell Function (in mice)

“The first thing we noticed was that the small intestine increases greatly in size on the high-calorie diet,” says study leader Anika Böttcher. “Together with Fabian Theis’ team of computational biologists at Helmholtz Munich, we then profiled 27,000 intestinal cells from control diet and high fat/high sugar diet-fed mice. Using new machine learning techniques, we thus found that intestinal stem cells divide and differentiate significantly faster in the mice on an unhealthy diet.” The researchers hypothesize that this is due to an upregulation of the relevant signaling pathways, which is associated with an acceleration of tumor growth in many cancers. “This could be an important link: Diet influences metabolic signaling, which leads to excessive growth of intestinal stem cells and ultimately to an increased risk of gastrointestinal cancer,” says Böttcher.

Helmholtz Zentrum München – German Research Center for Environmental Health. “New link between diet, intestinal stem cells and disease discovered.” ScienceDaily. http://www.sciencedaily.com/releases/2021/11/211119155604.htm (accessed November 27, 2021).

I wonder what Dr. Lustig would say about this study?

Dr. Robert Lustig – The Sugar Pandemic – 2012 Presentation at Yale University and Dr. Robert Lustig on Sugar.

Dead at Just 49 Years Old

Get tested.

Because the birth-cohort effect in cancer suggests that exposures early in life, during childhood or young adulthood, may be crucial, some have begun looking closely at changes to the microbiome. “We know that diet and lifestyle significantly shape our microbiome. They also significantly shape our immune system, which we need to fight off the development of cancer. And so we are hypothesizing that it’s a complex interplay among the microbiome, diet, lifestyle and your immune system,” Ng says.

The Colon Cancer Conundrum — https://www.nature.com/articles/d41586-021-03405-6

My cousin died from metastatic colon cancer at age 49.

Get tested.

You Want Fries With That?

Yes I would like fries with my double bacon cheeseburger.

The findings are from an analysis of 8015 emerging adults aged 18-25 in the cross-sectional National Health and Nutrition Examination Survey (NHANES), including NHANES II (1976-1980), NHANES III (1988-1994), and the continuous NHANES cycles from 1999 through 2018. The prevalence of obesity (BMI 30.0 kg/m2 or higher) in the emerging adult age group soared from 6.2% between 1976-1980 to 32.7% in 2017-2018 (P = .007).

Obesity Rates Soar in Early Adulthood in the US – Medscape – Nov 23, 2021. — https://www.medscape.com/viewarticle/963511?src=rss#vp_1

Original article – JAMA. Published online November 23, 2021. Abstract

I really need to finish writing my Future Best Seller.

The Myth of Retirement – 11.21.21

Rising prices inevitably impact the economy as consumers adjust their buying habits. https://www.visualcapitalist.com/u-s-inflation-which-categories-have-been-hit-the-hardest/

I think a lot of Americans who are preparing to retire now are going to have to rethink their plans. Because there’s no way the money that they’ve saved and the income streams that they anticipate receiving are going to be sufficient given the much higher cost of living that we’re going to be experiencing. And this is not just going to be a few percent a year. We’re talking double-digit increases in the cost of living for many, many years in a row.

Peter Schiff, chief global strategist of Euro Pacific Capital

A hedge against inflation in retirement is to keep working. My patented solution is twofold: Build a nest egg while working, and work for as long as possible, either doing what you’ve been doing, or doing something new and interesting and fun. Full-time is great, but even a part-time gig is great, and for all kinds of reasons, not just money, and even if you have plenty of money and don’t need to work.

Wolf Richter

Retirement math now is simple. If you can, work longer and save more.

The SupremeCmdr – The Myth of Retirement

Remember The Lobsterwoman!

Colonoscopy – Just Do It (an almost forgotten post)

I came across this post in my collection of unpublished drafts. I thought I posted this but obviously I didn’t. This article link was intended to be posted before Colorectal Cancer Rates Rising in Ages 50-54. Better late than never, I guess.

More than one quarter of colonoscopies carried out in Americans aged 30 to 49 years reveal some type of neoplasm, and slightly over 6% of these patients have advanced cancer, results of a nationally representative endoscopic registry show.

One Quarter of 30–49-Year-Olds Have Abnormal Colonoscopy Results – Medscape – Jun 07, 2021. — https://www.medscape.com/viewarticle/952536?src=rss#vp_1
APL = Advanced Premalignant Lesions. CRC = Colorectal cancer.

Also see Study Finds Sharp Rise in Colon Cancer and Rectal Cancer Rates Among Young Adults and Diet and Colon Cancer Risk – CBS News.

Colorectal Cancer Rates Rising in Ages 50-54

During the period 1992–2018, there were a total of 101,609 cases of CRC among adults aged 45–59 years. Further analysis showed that the CRC incidence rates rose from 23.4 to 34.0 per 100,000 among people aged 45–49 years and from 46.4 to 63.8 per 100,000 among those aged 50–54 years. Conversely, incidence rates decreased among individuals aged 55–59 years, from 81.7 to 63.7 per 100,000 persons.

Colorectal Cancer Rates Rising in People Aged 50 to 54 Years – Medscape – Nov 11, 2021 – https://www.medscape.com/viewarticle/962769?src=rss#vp_2

I am posting a link to this article as I enjoy the effects of 238 grams of Miralax mixed with a gallon of sports beverage and/or water. It certainly takes your mind off of not eating all day.

Transient Ischemic Attack (TIA) – a Primer

The incidence of TIA in the United States is estimated to be 200,000-500,000 per year, with a prevalence of 5 million individuals, but is likely underreported.2 Stroke is preceded by TIA in 12-30% of patients and is the 5th leading cause of death in the US, contributing significantly to long term disability.2,3 Strokes occur more commonly in men than women, but women experience more severe morbidity.2,3 Stroke prevalence increases with age and occurs more frequently in black and Hispanic populations.3 It should also be noted that 90% of strokes worldwide occur in the setting of potentially modifiable risk factors which presents an incredible opportunity for early intervention, especially following TIA.2

TIA: Emergency Department Evaluation and Disposition — http://www.emdocs.net/tia-emergency-department-evaluation-and-disposition/?utm_source=feedly&utm_medium=rss&utm_campaign=tia-emergency-department-evaluation-and-disposition

Need Retirement Income? – (Life Underwriters Need Not Worry)

The total number of life insurance policies sold rose 8% in the first six months of the year and marked the highest such growth since 1983, LIMRA said. And there were other indicators in that same data that pointed to positive signs: Total U.S. life insurance premium increased 21% in the second quarter 2021, the largest year-over-year increase since third quarter 1987; in addition, it was up 18% for the first half of 2021 compared to the prior year.

Life Insurance Sales Are Up, But for How Long? — https://news.ambest.com/articlecontent.aspx?refnum=313837&altsrc=2

I know who you are and I know what you want. If you are looking for ransom, I can tell you I don’t have very much money. But what I do have are a very particular set of skills; skills I have acquired over a very long career. Skills that are currently in short supply. Skills that I can and will take to the highest bidder.

The Supreme Commander

I last posted about my upcoming retirement in More Retirement Income Ahead!

I need to start referring to my upcoming retirement as What Retirement?

Quote for Today – 11.09.21

While researching home blood pressure monitors…

Doctor recommended purchasing a home BP monitor. The cuff gets entirely too tight. But more important, this monitor is grossly inaccurate. Never matches or even comes close to the readings I get in the doctor’s office. I had one reading of 297/182. I’d be dead if that was accurate. Don’t waste your money.

Online anonymous reviewer