Quote for Today – 10.29.22

Yes, change is the basic law of nature. But the changes wrought by the passage of time affects individuals and institutions in different ways. According to Darwin’s Origin of Species, it is not the most intellectual of the species that survives; it is not the strongest that survives; but the species that survives is the one that is able best to adapt and adjust to the changing environment in which it finds itself. Applying this theoretical concept to us as individuals, we can state that the civilization that is able to survive is the one that is able to adapt to the changing physical, social, political, moral, and spiritual environment in which it finds itself.

From a speech delivered in 1963 by a Louisiana State University business professor Leon C. Megginson at the convention of the Southwestern Social Science Association. The text of his address was published in the quarterly journal of the association. — https://quoteinvestigator.com/2014/05/04/adapt/

The quote above cites Darwin as the source of the phrase in bold.

Darwin never said it. https://www.darwinproject.ac.uk/people/about-darwin/six-things-darwin-never-said

Quote for Today – 10.22.22

The once-sleepy little town has gone in the same direction. After the influx of peripheral hippies that I was part of came the yuppies, Gen Xers, millennials, and more recently hipsters with their big beards, flannel shirts, and skinny jeans; many of them are the kind that move to a town with dirt streets because they think it’s charming, and then complain about the dust.

John Gierach – Dumb Luck and the Kindness of Strangers

Aging Well

Previous studies on aging have found that how people thought about themselves at age 50 predicted a wide range of future health outcomes up to 40 years later — cardiovascular events, memory, balance, will to live, hospitalizations; even mortality.”Previous research has shown that people who have positive views of aging at 50 live 7.5 years longer, on average, than people who don’t,” said Karen Hooker, co-author of the study and the Jo Anne Leonard Petersen Endowed Chair in Gerontology and Family Studies at OSU.

Oregon State University. “‘Aging well’ greatly affected by hopes and fears for later life.” ScienceDaily. http://www.sciencedaily.com/releases/2021/01/210121150929.htm (accessed January 23, 2021).

Journal Reference – Shelbie G. Turner, Karen Hooker. Are Thoughts About the Future Associated With Perceptions in the Present?: Optimism, Possible Selves, and Self-Perceptions of Aging. The International Journal of Aging and Human Development, 2020; 009141502098188 DOI: 10.1177/0091415020981883

IBS – Diet or Medication?

What are the new findings?

  • In a controlled trial enrolling 470 newly diagnosed primary care IBS patients, a self-management FODMAP-lowering smartphone application was superior to standard medical therapy in alleviating IBS symptoms.
  • The superiority of the diet app was already present at 4 weeks and persisted at 8 and 16 weeks.
  • The diet app had a high acceptability and adherence rate.
Diet or medication in primary care patients with IBS: the DOMINO study – a randomised trial supported by the Belgian Health Care Knowledge Centre (KCE Trials Programme) and the Rome Foundation Research Institute — https://gut.bmj.com/content/71/11/2226?rss=1

Fatal Fungi

This lethal lineup of mushrooms contains amatoxins, which include alpha, beta, and gamma amanitin. Amatoxin poisoning accounts for more than 90 percent of all deaths resulting from mushroom poisoning worldwide. Part of what makes them so deadly is that they can easily be confused with other, completely edible mushrooms. Death caps, for instance, can look much like straw and Gypsy mushrooms. The various destroying angels can be mistaken for button, meadow, and horse mushrooms. In Cleveland, Gholam recently treated a patient who had eaten a deadly Amanita mushroom he found in his yard after a plant identification app on his phone identified the mushroom as an edible variety. It almost killed him.

The mushrooms’ amatoxins are easily absorbed through the gastrointestinal tracts once they’ve been eaten. From there, the toxins head to the kidneys and, in particular, the liver, which is one of the most important organs in the body for making proteins. Amatoxins work by blocking a key enzyme involved in making new proteins, called RNA polymerase type II. In the liver, blocking this enzyme causes a cascade of trouble that results in cell death and tissue necrosis. While some of the toxin ultimately gets flushed in urine, some gets transported out of the liver with bile acids, where they end up back in the intestines for the process to begin again—in what’s called an enterohepatic cycle.

After ingestion, symptoms only appear six to 24 hours later, once significant damage has accumulated. Then the poisoning proceeds through three distinct phases. First, there’s gastrointestinal distress—marked by excruciating abdominal pain, nausea, vomiting, diarrhea, and blood in the urine—and can sometimes be accompanied by rapid heartbeat, low blood sugar, and dehydration. All that can last for 12 to 36 hours. Then, there’s the second, “latent” phase, when symptoms quiet down as liver and kidney damage set in at about 72 hours. In this phase, a person may be lulled into thinking they’re in the clear, potentially causing them to decline emergency medical care that could save their life.

In the three-to-five days after ingestion, things go downhill, with abrupt liver and multi-organ failure. Some patients end up needing liver transplants. Fatality rates vary but sometimes range between 10 and 20 percent, though some studies have found higher rates.

There are no specific treatments for amatoxin poisoning.

Ohio foragers are accidentally poisoning themselves with lethal mushrooms — https://arstechnica.com/science/2022/10/ohio-foragers-are-accidentally-poisoning-themselves-with-lethal-mushrooms/

“…a plant identification app on his phone identified the mushroom as an edible variety.”

Go ahead and search for the phrase “mushroom identification app” in your favorite search engine.

Foraging for wild mushrooms is a perfect example of you don’t know what you don’t know even if an app on your phone leads to believe you know.

Drive By Truckers

Up to one-third of crashes of large trucks are attributable to sleepiness, and large truck crashes result in more than 4,000 deaths annually. For each occupant of a truck who is killed, 6 to 7 occupants of other vehicles are killed.

Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that is characterized by repetitive episodes of complete or partial upper airway obstruction during sleep.1 OSA is common among adults,2,3 and it is particularly common in commercial operators.48 Untreated OSA leads to increased morbidity and mortality, as well as high costs related to crashes, health care use, absenteeism, and lost productivity.911 A systematic review and meta-analysis commissioned by the Federal Motor Carrier Safety Administration (FMCSA) shows that drivers with OSA have a crash risk that is between 21% and 489% higher than comparable drivers without OSA.12 A 2013 meta-analysis of more than 25,000 individuals who were enrolled in 12 studies shows that OSA was associated with an increased risk for cardiovascular disease (relative risk: 1.79), fatal and nonfatal stroke (relative risk: 2.15), and death from all causes (relative risk: 1.92).13

Obstructive sleep apnea screening, diagnosis, and treatment in the transportation industry – https://jcsm.aasm.org/doi/10.5664/jcsm.9672