The research, conducted in a mouse model, suggests how lifestyle and genetics converge. The researchers found that animals with an APC mutation, the most common genetic mutation found in humans with colorectal cancer, developed cancer faster when fed a high-fat diet.
The mice with APC mutations developed benign growths called adenomas. In humans, adenomas are common in the intestine and are routinely removed during colonoscopies. These growths normally take decades to turn into malignant adenocarcinomas. Yet the adenomas in these mice quickly turned cancerous when given high-fat diets.
During the years 2002 to 2013 in national databases, the incidence of colorectal cancer increased in patients younger than age 50 at a rate of 1.5% per year, for an average 15% increase over the study period, according to Hisham Hussan, MD, of the Ohio State University Wexner Medical Center in Columbus.
Source article here.
Conclusions – In this large prospective study, a 10% increase in the proportion of ultra-processed foods in the diet was associated with a significant increase of greater than 10% in risks of overall and breast cancer. Further studies are needed to better understand the relative effect of the various dimensions of processing (nutritional composition, food additives, contact materials, and neoformed contaminants) in these associations.
We categorized all food and drink items of the NutriNet-Santé composition table into one of the four food groups in NOVA, a food classification system based on the extent and purpose of industrial food processing.94243 This study primarily focused on the “ultra-processed foods” NOVA group. This group includes mass produced packaged breads and buns; sweet or savory packaged snacks; industrialized confectionery and desserts; sodas and sweetened drinks; meat balls, poultry and fish nuggets, and other reconstituted meat products transformed with addition of preservatives other than salt (for example, nitrites); instant noodles and soups; frozen or shelf stable ready meals; and other food products made mostly or entirely from sugar, oils and fats, and other substances not commonly used in culinary preparations such as hydrogenated oils, modified starches, and protein isolates. Industrial processes notably include hydrogenation, hydrolysis, extruding, moulding, reshaping, and pre-processing by frying. Flavouring agents, colours, emulsifiers, humectants, non-sugar sweeteners, and other cosmetic additives are often added to these products to imitate sensorial properties of unprocessed or minimally processed foods and their culinary preparations or to disguise undesirable qualities of the final product.
Read the BMJ study here.
In rats. But it’s the behavior of the sugar industry rats that is more disturbing.
Read the entire study here.
Our study contributes to a wider body of literature documenting industry manipulation of science. Industries seeking to influence regulation have a history of funding research resulting in industry-favorable interpretations of controversial evidence related to health effects of smoking [15,16], therapeutic effects of pharmaceutical drugs [17,18], the relationship between sugar-sweetened beverage consumption and weight gain or obesity , and the causes of climate change,  among other issues. The tobacco industry also has a long history of conducting research on the health effects of its products that is often decades ahead of the general scientific community and not publishing results that do not support its agenda [20–23]. This paper provides empirical data suggesting that the sugar industry has a similar history of conducting, but not publishing studies with results that are counter to its commercial interests.
The study was published online October 31 in Gut.
The researchers point out, however, that this was an observational study, which can’t prove cause and effect.
A strength of the study is its use of data from a large population-based database with complete information on subsequent diagnoses and drug prescriptions, which minimizes selection, information, and recall biases, the researchers say. Use of strict exclusion criteria as well as propensity score adjustment to control for potential confounders and restricting the sample to patients with successful H pylori eradication are other strengths.
In terms of study weaknesses, the researchers lacked information on some risk factors, such as diet, family history, and socioeconomic status. And despite the large sample of more than 63,000 H pylori–infected patients, the small number of gastric cancer cases did not allow for any “meaningful evaluation of the dosage effect and role of different PPIs,” the researchers say.