Depression and Accelerated Biological Aging

“These patients show evidence of accelerated biological aging, and poor physical and brain health,” which are the main drivers of this association, says Breno Diniz, a UConn School of Medicine geriatric psychiatrist and author of the study, which appears in Nature Mental Health on March 22.

Diniz and colleagues from several other institutions looked at 426 people with late-in-life depression. They measured the levels of proteins associated with aging in each person’s blood. When a cell gets old, it begins to function differently, less efficiently, than a “young” cell. It often produces proteins that promote inflammation or other unhealthy conditions, and those proteins can be measured in the blood. Diniz and the other researchers compared the levels of these proteins with measures of the participants’ physical health, medical problems, brain function, and the severity of their depression.

University of Connecticut. “Depressed, and aging fast: Older adults with late-in-life-depression age biologically older than their chronological peers..” ScienceDaily. http://www.sciencedaily.com/releases/2023/03/230322190947.htm (accessed March 25, 2023).

Journal Reference:

Johanna Seitz-Holland, Benoit H. Mulsant, Charles F. Reynolds III, Daniel M. Blumberger, Jordan F. Karp, Meryl A. Butters, Ana Paula Mendes-Silva, Erica L. Vieira, George Tseng, Eric J. Lenze, Breno S. Diniz. Major depression, physical health and molecular senescence markers abnormalities. Nature Mental Health, 2023; 1 (3): 200 DOI: 10.1038/s44220-023-00033-z

Social Frailty

Social frailty is a corollary to physical frailty, a set of vulnerabilities (including weakness, exhaustion, unintentional weight loss, slowness, and low physical activity) shown to increase the risk of falls, disability, hospitalization, poor surgical outcomes, admission to a nursing home, and earlier death in older adults.

For seniors who want to think about their own social vulnerability, consider this five-item index, developed by researchers in Japan.

(1) Do you go out less frequently now than last year?

(2) Do you sometimes visit your friends?

(3) Do you feel you are helpful to friends or family?

(4) Do you live alone?

(5) Do you talk to someone every day?

Being ‘Socially Frail’ Comes With Health Risks for Older Adults — https://khn.org/news/article/socially-frail-older-adults-health-risks/

I passed the quiz.

Meet Bobi, the World’s Oldest Dog

At 30 years and 266 days old, a Portuguese dog named Bobi was crowned the world’s oldest dog ever on February 1, breaking an almost century-old record, per Guinness World Records (GWR). The previous titleholder, an Australian cattle dog named Bluey, was born in 1910 and lived for 29 years and 5 months. 

Meet Bobi, the World’s Oldest Dog — https://www.smithsonianmag.com/smart-news/meet-bobi-the-worlds-oldest-dog-180981601/

See for yourself.

Bobi is 164 years old in human years. See https://www.akc.org/expert-advice/health/how-to-calculate-dog-years-to-human-years/

Food Addiction

Addiction to Highly Processed Food Among Older Adults — https://www.healthyagingpoll.org/reports-more/report/addiction-highly-processed-food-among-older-adults

Read the press release here – https://ihpi.umich.edu/news/1-8-americans-over-50-show-signs-food-addiction-u-m-poll-finds

Read more about the Yale Food Addiction Scale here – https://sites.lsa.umich.edu/fastlab/yale-food-addiction-scale/

Step 1: I admit I am powerless over pizza.

The picture above is a normal size slice at Benny’s. The tall beer can was strictly in the picture to provide perspective. For more about Benny’s see https://garyskitchen.net/worship-the-whale/.

Social Isolation and Dementia Risk

A study by Huang and colleagues is the first nationally representative cohort study examining the association between social isolation and incident dementia for older adults in community dwelling settings. A cohort of 5,022 older adults participating in the National Health and Aging Trends Study was followed from 2011 to 2020. When adjusting for demographic and health factors, including race, level of education, and number of chronic health conditions, socially isolated adults had a greater risk of developing dementia, compared with adults who were not socially isolated (hazard ratio, 1.27; 95% CI, 1.08 – 1.49). Potential mechanisms to explain this association include the increased risk of cardiovascular disease and depression in older adults who are socially isolated, thereby increasing dementia risk.

Mengru Wang. Geriatrician Advises on Use of Vitamin D Supplementation, Lecanemab, and Social Media for Her Patients – Medscape – Jan 20, 2023 — https://www.medscape.com/viewarticle/987285?src=rss#vp_2

One week ago we had our older adult friends over for dinner. Midweek my wife went out with her friends while I gathered with my friends. Last night was date night and we got out of the house. This evening we’re having dinner at a friend’s house.

Dementia risk reduction activities!

Some Old Statistics

The Administration for Community Living (ACL) has published its profile of older Americans 2021, an annual summary of critical statistics related to the older population. The updated report shows an older population that’s increasing in size and diversity.

The older population is growing and becoming more diverse — https://healthjournalism.org/blog/2022/12/the-older-population-is-growing-and-becoming-more-diverse/

And in case you’re thinking none of this matters because you are still young…

We found that midlife, generally considered to encompass the ages of 40 to 65, has become a time of crisis…the midlife crisis experienced by most people is subtler, more nuanced and rarely discussed among family and friends. It can be best described as the “big squeeze” – a period during which middle-aged adults are increasingly confronted with the impossible choice of deciding how to split their time and money between themselves, their parents and their kids.

The real midlife crisis confronting many Americanshttps://theconversation.com/the-real-midlife-crisis-confronting-many-americans-114347

Due to the holiday, travel, and entertaining I’ve been spending less time in front of my screens.

Well, time to get back to my normal screen time habit.

Aging Well

Previous studies on aging have found that how people thought about themselves at age 50 predicted a wide range of future health outcomes up to 40 years later — cardiovascular events, memory, balance, will to live, hospitalizations; even mortality.”Previous research has shown that people who have positive views of aging at 50 live 7.5 years longer, on average, than people who don’t,” said Karen Hooker, co-author of the study and the Jo Anne Leonard Petersen Endowed Chair in Gerontology and Family Studies at OSU.

Oregon State University. “‘Aging well’ greatly affected by hopes and fears for later life.” ScienceDaily. http://www.sciencedaily.com/releases/2021/01/210121150929.htm (accessed January 23, 2021).

Journal Reference – Shelbie G. Turner, Karen Hooker. Are Thoughts About the Future Associated With Perceptions in the Present?: Optimism, Possible Selves, and Self-Perceptions of Aging. The International Journal of Aging and Human Development, 2020; 009141502098188 DOI: 10.1177/0091415020981883

Another Sweet Saturday – 09.17.22

Our 1-year RCT indicated that a lifestyle intervention program can be highly successful in older adults with diabetes and chronic comorbidities. In this specific population, lifestyle intervention not only improved glycemic control associated with improved insulin action and secretion but also improved age-relevant outcomes such as body composition, physical function, and quality of life.

Alessandra Celli, Yoann Barnouin, Bryan Jiang, Dean Blevins, Georgia Colleluori, Sanjay Mediwala, Reina Armamento-Villareal, Clifford Qualls, Dennis T. Villareal; Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial. Diabetes Care 1 September 2022; 45 (9): 1943–1952. https://doi.org/10.2337/dc22-0338

From the periods 1988–1994 to 2017 to March 2020, there was an increase in the prevalence of diagnosed diabetes (from 4.6% to 11.7%), but no change in prevalence of persistent undiagnosed diabetes (from 2.23% to 2.53%) or confirmed undiagnosed diabetes (from 1.10% to 1.23%). Consequently, the proportion of all undiagnosed diabetes cases declined from 32.8% to 17.8% (persistent undiagnosed diabetes) and from 19.3% to 9.5% (confirmed undiagnosed diabetes). Undiagnosed diabetes was more prevalent in older and obese adults, racial/ethnic minorities, and those without health care access. Among persons with diabetes, Asian Americans and those without health care access had the highest proportion of undiagnosed cases, with rates ranging from 23% to 61%.

Michael Fang, Dan Wang, Josef Coresh, Elizabeth Selvin; Undiagnosed Diabetes in U.S. Adults: Prevalence and Trends. Diabetes Care 1 September 2022; 45 (9): 1994–2002. https://doi.org/10.2337/dc22-0242

Remember, Stay as Thin as You Can as Long as You Can.

The Biggest Life Event That No One Talks About

Retirement is more than a transition in our relationship with money. It is a major shift in our sense of self. The work that has defined our lives for decades begins to fade from view. Everything about life is different after retirement, down to the minute details of the daily routine. I think it is important to ask yourself, who am I without my job, without my career? And more importantly, how will I spend my time? How will I spend my days, weeks, months, seasons, and years once the routine ends? These are vital questions for anyone contemplating retirement. For many, the allure of endless days on the beach or in the garden loses its luster quite fast. The risk of becoming bored is a real and unexpected risk that many retirees face.

https://blairbellecurve.com/the-biggest-life-event-that-no-one-talks-about/

The endless string of triple digit days has finally ended. I’m so thankful that it’s not Too Hot to Blog and the writing is free and effortless once again. I’m still thinking strategy because having A Plan is Not a Strategy – Update 08.03.22. Yet time and time again the question begs an answer. How will I spend my time in retirement?

As long as I continue working the question doesn’t require an answer.

I guess I’ll keep working.