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Efficacy and Safety of Linagliptin in Subjects With Long-Standing Type 2 Diabetes Mellitus >10 Years: Evidence From Pooled Data of Randomized, Double-Blind, Placebo-Controlled, Phase III Trials – Clinical Therapeutics
What’s Your CRF? – Johns Hopkins Health Alerts
What’s Your CRF?: Johns Hopkins Health Alerts.
Johns Hopkins Health Alert
What’s Your CRF?
Engaging in regular physical activity has long been recognized as a key ingredient to a healthy heart. That’s because aerobic activities such as jogging, walking and bike riding can help improve blood circulation, insulin sensitivity and blood pressure, as well as assist in quitting smoking, maintaining a healthy weight, managing stress and warding off depression. Unfortunately, many people aren’t getting up and moving for their health.
The Centers for Disease Control and Prevention reports that only about 22 percent of adults participate in regular, sustained activity (defined as the recommended five times a week for a minimum of 30 minutes), and about 25 percent of adults admit to engaging in no physical activity in their downtime.
Complicating matters is that many people may be overestimating how active they really are. In one study, British researchers report that almost half of participants deemed “inactive” inaccurately labeled themselves as “active,” making it more difficult to target these individuals for lifestyle interventions.
Putting older adults at a further disadvantage, cardiorespiratory fitness (CRF) levels — essentially a measurement of your body’s ability to supply the necessary oxygen during physical activity — also tend to decrease as we age. And while CRF levels haven’t received as much attention as risk factors such as high blood pressure and high cholesterol, many experts say low CRF levels are a separate, serious risk factor for cardiovascular disease.
The numbers behind CRF. Preliminary results from the Kuopio Ischemic Heart Disease Risk Factor Study, which looked at more than 2,600 Finnish men between the ages of 42 and 60, spell out the consequences: Those people whose CRF levels decreased more than 15 percent over a decade increased their risk of heart attack by 88 percent and faced a 122 percent increased risk of dying of any cause. Previous research found significant increases in risk as well.
So how do people know if they’re “heart fit”? In a clinical setting, CRF can be measured with simple exercise stress tests. These tests are performed with the subject either walking or running on a treadmill or pedaling a special stationary bike equipped to measure exercise output. The results are expressed in METs, or metabolic equivalents.
A study published in the New England Journal of Medicine found that the minimum output needed to preserve overall heart health was 7.9 METs. Relating to real life, that’s a 50-year-old man being able to walk continuously at a speed of 4 miles per hour during the test, and 3 miles per hour for a woman.
Posted in Heart Health on October 31, 2014
Medical Disclaimer: This information is not intended to substitute for the advice of a physician. Click here for additional information: Johns Hopkins Health Alerts Disclaimer
Ultrasound of the Week | UOTW #17
Fish Oil Slows Cognitive Decline, With Caveats
Fish Oil Slows Cognitive Decline, With Caveats.
Disclosures
- This study was done at Rhode Island Hospital. I have been a participant in a longitudinal weight loss study with this facility for many years.
- My son is a physician at this hospital.
- I like fish.
Statins: The Good, the Bad, and the Unknown
Alcohol Involvement in Opioid Pain Reliever and Benzodiazepine Drug Abuse–Related Emergency Department Visits and Drug-Related Deaths — United States, 2010
The analyses showed alcohol was involved in 18.5% of OPR and 27.2% of benzodiazepine drug abuse-related ED visits and 22.1% of OPR and 21.4% of benzodiazepine drug-related deaths. These findings indicate that alcohol plays a significant role in OPR and benzodiazepine abuse. Interventions to reduce the abuse of alcohol and these drugs alone and in combination are needed.
Five Lessons From the Niacin Failure
Five Lessons From the Niacin Failure.
Niacin With Statins? No Dice..
HPS2-THRIVE: As Niacin Fails, HDL’s Role Is Debated Anew.
Enjoy these articles. Taking niacin? Well…
Emergency Medicine News – THC Dosing of Edible Marijuana in Colorado is Insane.
Avoid couchlock! Four things to know about cannabis pharmacology | The Poison Review.
Recently, the New York Times’ Pulitzer Prize-winning columnist Maureen Dowd got into trouble in Denver when she overdosed on a cannabis candy bar and experienced 8 hours of paranoia and couchlock.
Toxicology Rounds: Four Things Maureen Dowd Should Have Know… : Emergency Medicine News.
THC dosing of edible marijuana in Colorado is insane. Richard Zane, MD, the chairman of emergency medicine at the University of Colorado Medical Center in Denver, said on the National Public Radio talk show On Point that the amount of THC in some marijuana edibles is completely irrational. The usual recommended moderate starting dose is approximately 10 mg THC, and some cookies can contain six doses and some lollipops as many as 10. Dr. Zane said the university’s ED sees out-of-state marijuana tourists every day who present with bad reactions to THC, such as agitation, unremitting violent vomiting, hallucinations, and psychosis.
And finally, a link to Maureen Dowd’s column.
Don’t Harsh Our Mellow, Dude – NYTimes.com.
In March, a 19-year-old Wyoming college student jumped off a Denver hotel balcony after eating a pot cookie with 65 milligrams of THC. In April, a Denver man ate pot-infused Karma Kandy and began talking like it was the end of the world, scaring his wife and three kids. Then he retrieved a handgun from a safe and killed his wife while she was on the phone with an emergency dispatcher.
JAMA – Treating Prescription Opioid Dependence
JAMA Network | JAMA | Treating Prescription Opioid Dependence.
Conclusions and Relevance This study represents a rigorous experimental evaluation of outpatient buprenorphine stabilization, brief taper, and naltrexone maintenance for treatment of PO dependence. Results suggest that a meaningful subset of PO-dependent outpatients may respond positively to a 4-week
Naltrexone maintenance? I bet they’ll lost weight too.
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