
Duh.

Duh.
Click on the link for the NEJM Journal Watch weekly update. Another good week for SARS-CoV-2 articles. I did not forget this week AND I’m not going out of town until Sunday.
https://www.jwatch.org/fw117653/2021/03/27/latest-covid-19-news-week-ending-mar-27
Meanwhile I just heard this for the first time this week.
Seven out of eight emergency department (ED) visits attributed to adverse events from benzodiazepines involve self-harm or nonmedical use of these drugs, and more than 80% involve concurrent use of alcohol, illicit drugs, or other substances, new research shows.
Although benzodiazepines are typically not problematic in terms of acute overdoses when used alone, patients often don’t take them as prescribed or use them with other substances in a self-harm attempt, author Daniel S. Budnitz, MD, MPH, director of the Medication Safety Program, Centers for Disease Control and Prevention (CDC), told Medscape Medical News.
“Clinicians need to be aware of what other substances patients might be taking when they’re being prescribed a benzodiazepine,” Budnitz added.
The study was published online February 19 in the American Journal of Preventive Medicine.
Benzodiazepines Implicated in High Rate of ED Visits Across US – Medscape – Feb 25, 2020 – https://www.medscape.com/viewarticle/925686#vp_1
“Major issues” that may have to be managed in the context of acute intoxication with propylhexedrine include severe agitation, tachycardia, hypertension, myocardial infarction, hyperthermia, stroke, bowel obstruction, pulmonary hypertension, and seizures, the FDA said.There is no specific agent for reversing the effects of acute propylhexedrine intoxication, so management is symptomatic and supportive, the FDA notes.
Abuse of OTC Decongestant Potentially Deadly – https://www.medscape.com/viewarticle/948125?src=rss
This is an OTC decongestant I’ve never heard of nor used.
I’m speechless.
YIKES!
Somehow I missed this article from 2019 https://www.medscape.com/viewarticle/922914
“I took the medication only as prescribed,” Bobbi said. After her benzodiazepine was stopped abruptly, she suffered multiple disabling neurological symptoms, including seizures, cognitive and visual impairment, difficulty walking, and hand contractures, leaving her unable to work. Bobbi is one of many patients my advocacy organization helped report their harm to the FDA. Our goal was to raise awareness of the adverse effects of benzodiazepines and advocate for stronger warning labels.
Thus, I was pleasantly surprised last September to see the FDA’s drug safety communication announcing an update to the boxed warning for benzodiazepines “to address the serious risks of abuse, addiction, physical dependence, and withdrawal reactions.” Curious, I filed a FOIA request for the FDA’s 175-page report on benzodiazepines. Many of the document’s conclusions raise the same concerns benzodiazepine safety advocates have had for decades.
updated benzodiazepine boxed warning: What you need to know — https://www.kevinmd.com/blog/2021/03/the-updated-benzodiazepine-boxed-warning-what-you-need-to-know.html
I downloaded the FDA report for future reference.
The report should be fun weekend reading.
People take apoaequorin to prevent the decline in memory and thinking skills that occurs normally with age and to improve memory, but there is no good scientific evidence to support its use for these or other conditions.
https://www.webmd.com/vitamins/ai/ingredientmono-1486/apoaequorin
That’s it. That’s the post.
Click on the link for the NEJM Journal Watch weekly update. Another good week for SARS-CoV-2 articles. Sorry about not posting last week’s Journal Watch link of links. I forgot AND I was out of town which made me forget.
https://www.jwatch.org/fw117630/2021/03/20/latest-covid-19-news-week-ending-mar-20-2021
Meanwhile Sammy sings from what appears to be an empty closet.
#2 Remember naloxone, glucose, and thiamine (NGT)
Original: Consider or give naloxone, glucose and thiamine
The number of patients presenting with opioid intoxication is growing, and the gentle reversal of patients without severe respiratory depression with naloxone is in the art of medicine – consider starting with 0.4mg and titrate to effect.In contrast to empiric administration of glucose in the altered or ill patient, rapid assessment of glucose level with point-of-care testing is recommended.
Thiamine deficiency may be less prevalent than previously thought in intoxicated patients, but we now know that giving 100mg of IV thiamine can benefit other malnourished patients, including those with calorie-malnourishment from cancer, gastric bypass, hyperemesis gravidarum, and eating disorders. Personally, I use the ‘T’ of ‘NGT’ to remind myself not to miss alcohol withdrawal.
Ten Commandments of Emergency Medicine Revisited — https://journalfeed.org/article-a-day/2021/ten-commandments-of-em-revisited
Why does this matter? I hear you thinking we underwrite life insurance, we’re not doctors. So true. But if we think like doctors we will get better at what we do by recognizing the subtleties buried within the medical charts we read. Here’s what my eyes/brain picked up.
The bold in the excerpt above are mine to illustrate how the mind of a mortality risk expert works. In Emergency Department records pay attention to the initial treatments provided which in some cases hints to a serious condition impacting mortality. Naloxone and opioids are obvious. But would you have associated the administration of IV thiamine to malnutrition or alcohol withdrawal? I thought so.
So read and research widely. You’ll always find little jewels to improve your skills and to impress your friends with. Or in my case to make Dr. Lee think his old man knows more than he actually does.
Pre-print therefore not peer reviewed. No, I don’t hang out on Twitter all day long. Yes, the study is somewhat geeky. BUT here’s the money sentence:
This abrogation of the species barrier raises the possibility of wild rodent secondary reservoirs and provides new experimental models to study disease pathophysiology and countermeasures.
The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice — https://www.biorxiv.org/content/10.1101/2021.03.18.436013v1
Now I can’t stop thinking about “secondary reservoirs”.
And minks.
Just remember if you get vaccinated you can still curl up with your furry friends worry free.
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