Metabolic Adaptation in Obesity

Awareness of Metabolic Adaptation

When patients lose weight, the body desires to regain it via metabolic adaptation that decreases energy use, enhances metabolic efficiency, and prompts increased energy intake. With metabolic adaptation, a person recognizes that as they try a particular therapy, whether lifestyle, medication, surgery, or an endoscopic therapy, it initially feels relatively easy to do and maybe their weight responds. However, over time on therapy, continued weight loss becomes more and more challenging due to the alteration in hormone levels such as ghrelin, leptin, and glucagon-like peptide-1 (GLP-1). For example, increasing ghrelin levels stimulate a person to eat more, and falling GLP-1 levels cause a person to not feel as full.

Key Considerations for Maintaining a Healthy Weight to Reduce the Risk of Cardiometabolic Complications in Patients With Obesity Fatima Cody Stanford, MD, MPH, MPA, MBA — https://www.clinicaloptions.com/diabetes/programs/2021/obesityprimarycare2021

Because of my social media activities my name and email address have found their way into some interesting email marketing lists. This quote comes from an email I got a few days ago. I actually went to the website, was granted guest access and downloaded the slide deck. Most of the information in the presentation was WAY above my pay grade.

Author Disclosure – I am not a medical doctor. I’m an insurance guy.