Conclusion All NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort — https://gut.bmj.com/content/early/2020/10/09/gutjnl-2020-322786?rss=1
Diet. That’s it. That’s my post.
A finding of any type of polyp in the colon increases the risk for colorectal cancer (CRC), according to new findings from a large Swedish study.
At 10 years, the cumulative colorectal cancer incidence was 1.6% among patients with hyperplastic polyps, 2.5% among those with sessile serrated polyps, 2.7% for tubular adenomas, 5.1% for tubulovillous adenomas, and 8.6% for villous adenomas, as compared with 2.1% for the control group.
However, a higher risk for colorectal-related death was only observed in patients with sessile serrated polyps, tubulovillous adenomas, or villous adenomas.
The study was published online March 16 in Lancet Gastroenterology & Hepatology.
Any Type of Polyp Increases the Risk for Colorectal Cancer
Boldface sections are mine.
I had my first virtual visit with my physician yesterday. I mentioned that I was postponing my colonoscopy this year for pandemic reasons. She said that’s fine, don’t worry about it. I read this article today. Now I know why I’m on a three year callback.
In conclusion, these two outstanding studies support the fact that (1) it is not the quantity of calories per se that matters but the quality of the diet and (2) even in subjects of advanced age, adherence to a MedDiet is rapidly associated with different metabolic effects and reduced disease risk factors.
Mediterranean diet, gut microbiota and health: when age and calories do not add up!
I roll in my bed, unable to sleep. I listen to BBC talk about the craziness that took over the world, preoccupied with this one question. What question? It’s not: “Why, Corona?” For that, I already have more answers than I want. Scientists say that COVID19 is an animal virus. It spread to humans from…
via Why Toilet Paper? — RadaJonesMD
Here’s when you should (and shouldn’t) trust your gut
This was an interesting article from Fast Company written by…
Now, we live in a world that values logic and considers emotions as weak. It seems like decisions based on intuition have little or no place in today’s society. Over time, we’ve neglected the gut and the limbic brain, and placed the cortex on a pedestal. We’ve demoted depth, passion and instinct to fixate on surface-level capabilities—exams, rote-learning, and transactional relationships. We are more connected with material gain than joy. At the same time, increased stress, processed food, and antibiotics have massively diminished the biodiversity of our gut flora, which compromises more than our physical resilience.
According to Dr. Sadeghi, fiber-rich foods are generally enough to boost and maintain a healthy gut biome. While companies claim to have packaged the secret to digestion via fermented foods—such as yogurt, sauerkraut, kombucha, wine, and cheese—the truth is there is no recognized scientific evidence to support these claims. Dr. Sadeghi stated, “There are no studies which have actually looked at whether these probiotics get incorporated into the gut mucosa or get discarded into the stool. In fact, we don’t even know for sure they aren’t harmful. In a recent study published in Cell, researchers looked at whether probiotics get incorporated into the mucosa post antibiotic therapy to restore gut health. They did colonoscopies on two groups of individuals and samples their biome. Both groups received antibiotics. One group received probiotics and the other group did not receive probiotics. They wanted to know whether taking probiotics restored the health of the gut faster. To their surprise, the group that didn’t get probiotics recovered the biome faster!”
Gastroenterologist Busts Link Between Fermented Dairy and Gut Health
Link to Dr. Angie Sadeghi’s website.
Conclusions This nationwide, unselected, cohort study shows a significant association between IBD and later occurrence of PD, which is consistent with recent basic scientific findings of a potential role of GI inflammation in development of parkinsonian disorders.
The full study in PDF is available here.
The researchers identified patients with inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn’s disease between the years 1964 and 2014 via the Swedish patient register. Using these data, they compared mortality rates in about 9,400 children who developed IBD with those of other children.
Their results show that children who developed IBD before the age of 18 have a three to five-fold higher mortality rate than people without IBD, both during childhood and into adulthood. This translates to a 2.2-year reduction in life expectancy in individuals monitored up to the age of 65.
Study abstract.Study abstract.