NAFLD – Why are Life Insurers Taking This Risk at Standard Rates?

Conclusion All NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.

Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort — https://gut.bmj.com/content/early/2020/10/09/gutjnl-2020-322786?rss=1

Diet. That’s it. That’s my post.

Meat Intake and Colorectal Polyps

Meat Intake and Colorectal Polyps

Research professor of medicine Martha Shrubsole, Ph.D., and colleagues at Vanderbilt University Medical Center have published the first study to evaluate intakes of meat, cooking methods and meat mutagens and risk of developing sessile serrated polyps (SSPs, also called sessile serrated lesions). Shrubsole previously reported that consuming high levels of red meat increased the risk of developing all types of polyps, but that the likelihood of developing SSPs was two times greater than the risk of developing adenomas and hyperplastic polyps (HP).

Conventional colorectal adenomas are the precursor lesions for most colorectal cancers. SSPs, however, represent an alternative pathway to carcinogenesis that may account for up to 35 percent of colorectal cancers. Because a diagnostic consensus for SSPs was not reached until 2010, few epidemiologic studies have evaluated risk factors.

 

Any Polyp Type Raises CRC Risk

A finding of any type of polyp in the colon increases the risk for colorectal cancer (CRC), according to new findings from a large Swedish study.

At 10 years, the cumulative colorectal cancer incidence was 1.6% among patients with hyperplastic polyps, 2.5% among those with sessile serrated polyps, 2.7% for tubular adenomas, 5.1% for tubulovillous adenomas, and 8.6% for villous adenomas, as compared with 2.1% for the control group.

However, a higher risk for colorectal-related death was only observed in patients with sessile serrated polyps, tubulovillous adenomas, or villous adenomas.

The study was published online March 16 in Lancet Gastroenterology & Hepatology.

Any Type of Polyp Increases the Risk for Colorectal Cancer

Boldface sections are mine.

I had my first virtual visit with my physician yesterday.  I mentioned that I was postponing my colonoscopy this year for pandemic reasons.  She said that’s fine, don’t worry about it.  I read this article today.  Now I know why I’m on a three year callback.

 

Here’s when you should (and shouldn’t) trust your gut

Here’s when you should (and shouldn’t) trust your gut

This was an interesting article from Fast Company written by…

A neuroscientist!

Now, we live in a world that values logic and considers emotions as weak. It seems like decisions based on intuition have little or no place in today’s society. Over time, we’ve neglected the gut and the limbic brain, and placed the cortex on a pedestal. We’ve demoted depth, passion and instinct to fixate on surface-level capabilities—exams, rote-learning, and transactional relationships. We are more connected with material gain than joy. At the same time, increased stress, processed food, and antibiotics have massively diminished the biodiversity of our gut flora, which compromises more than our physical resilience.

Eat More Fiber

According to Dr. Sadeghi, fiber-rich foods are generally enough to boost and maintain a healthy gut biome. While companies claim to have packaged the secret to digestion via fermented foods—such as yogurt, sauerkraut, kombucha, wine, and cheese—the truth is there is no recognized scientific evidence to support these claims. Dr. Sadeghi stated, “There are no studies which have actually looked at whether these probiotics get incorporated into the gut mucosa or get discarded into the stool. In fact, we don’t even know for sure they aren’t harmful. In a recent study published in Cell, researchers looked at whether probiotics get incorporated into the mucosa post antibiotic therapy to restore gut health.[1] They did colonoscopies on two groups of individuals and samples their biome. Both groups received antibiotics. One group received probiotics and the other group did not receive probiotics. They wanted to know whether taking probiotics restored the health of the gut faster. To their surprise, the group that didn’t get probiotics recovered the biome faster!”

Gastroenterologist Busts Link Between Fermented Dairy and Gut Health

Link to Dr. Angie Sadeghi’s website.

 

Increased Mortality of Patients with Childhood-onset Inflammatory Bowel Diseases, Compared With the General Population

The researchers identified patients with inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn’s disease between the years 1964 and 2014 via the Swedish patient register. Using these data, they compared mortality rates in about 9,400 children who developed IBD with those of other children.

Their results show that children who developed IBD before the age of 18 have a three to five-fold higher mortality rate than people without IBD, both during childhood and into adulthood. This translates to a 2.2-year reduction in life expectancy in individuals monitored up to the age of 65.

Source article.

Study abstract.Study abstract.