Linzess – Think IBS with Constipation

Linzess is felt to act as a guanylate cyclase-C agonist. An agonist increases the activity of a process, the opposite of an antagonist. Linzess seems to act locally on the surface of the inside of the intestinal lining cells and by activation of guanylate cyclase-C increases levels of intracellular cGMP (cyclic guanosine monophosphate) which results in increased levels of chloride and bicarbonate in the intestinal lumen and speeds up gastrointestinal transit.

via Does Linzess have a role in IBS with constipation?.

Mirapex (pramipexole) Possible Risk of Heart Failure

ISSUE: FDA notified healthcare profesionals about a possible increased risk of heart failure with Mirapex (pramipexole). Results of recent studies suggest a potential risk of heart failure that needs further review of available data. Because of the study limitations, FDA is not able to determine whether Mirapex increases the risk of heart failure. FDA is continuing to work with the manufacturer to clarify further the risk of heart failure with Mirapex and will update the public when more information is available.

via Safety Alerts for Human Medical Products > Mirapex (pramipexole): Drug Safety Communication – Ongoing Safety Review, Possible Risk of Heart Failure.

Heavy Drinking May Lead to Early Stroke

Drinking three or more alcoholic beverages a day may raise the risk for spontaneous intracerebral hemorrhage at a much younger age than typical, researchers found.

These strokes occurred at an average age of 60 with such high alcohol consumption, 14 years earlier than seen without heavy drinking (P<0.0001), Charlotte Cordonnier, MD, PhD, of the University of Lille Nord de France in Lille, France, and colleagues,

Heavy drinking also predicted a near doubling in 2-year mortality risk after a deep intracerebral hemorrhage before age 60, the group reported in the Sept. 11 issue of Neurology.

via Heavy Drinking May Lead to Early Stroke.

NIA at NIH Press Release 08.16.2012 – Status of Older Americans

NIA NEWS
For Immediate Release

Thursday, August 16, 2012

Federal report details health, economic status of older Americans

Today’s older Americans enjoy longer lives and better physical function than did previous generations, although, for some, an increased burden in housing costs and rising obesity may compromise these gains, according to a comprehensive federal look at aging. The report, Older Americans 2012: Key Indicators of Well-Being, tracks trends at regular intervals to see how older people are faring as the U.S. population grows older.

In 2010, 40 million people age 65 and over accounted for 13 percent of the total population in the United States. In 2030, the number and proportion of older Americans is expected to grow significantly—to 72 million, representing nearly 20 percent of the population said the report, by the Federal Interagency Forum on Aging-Related Statistics.

Older Americans 2012, the sixth report prepared by the Forum since 2000, provides an updated and accessible compendium of indicators, drawn from official statistics about the well-being of Americans primarily age 65 and older. The 176-page report provides a broad description of areas of well-being that are improving for older Americans and those that are not. Thirty-seven key indicators are categorized into five broad areas—population, economics, health status, health risks and behaviors, and health care. This year’s report also includes a special feature on the end of life.

Highlights of Older Americans 2012 include:

  • Increased labor force participation by older women – Participation of older women in the labor force has increased significantly over the past 40 years. In 1963, 29 percent of women aged 62-64 worked outside the home; in 2011, that had increased to 45 percent. In 1963, 17 percent of women aged 65-69 were in the labor force; in 2011, that had increased to 27 percent. For women 70 and older, 6 percent worked in 1963, increasing to 8 percent in 2011. Some older Americans work out of economic necessity. Others may be attracted by the social contact, intellectual challenges or sense of value that work often provides.
  • Declines in poverty, increases in income since 1974 – Older Americans are in better economic shape now than they were in 1974. Between 1974 and 2010, the proportion of older people with income below the poverty thresholds (less than $10,458 in 2010 for a person 65 and older) fell from 15 percent to 9 percent. The percentage with low income (between $10,458 and $20,916 in 2010 for people 65 and older) dropped from 35 percent to 26 percent. There were also notable gains in income over the period, as the proportion of people 65 and older with high income ($41,832 and above in 2010) rose from 18 percent to 31 percent.
  • Increased housing problems –The most significant issue by far is housing cost burden, which has been steadily increasing over time. In 1985, about 30 percent of households with householders or spouses age 65 and over spent more than 30 percent of their income on housing and utilities. By 2009, the proportion of older people with high housing cost burden reached 40 percent. For some multigenerational households, crowded housing is also fairly prevalent.
  • Rising rates of obesity – Obesity, a major cause of preventable disease and premature death, is increasing among older people. In 2009-2010, 38 percent of people age 65 and over were obese, compared with 22 percent in 1988-1994. In 2009-2010, 44 percent of people age 65-74 were obese, as were 29 percent of those age 75 and older.
  • More use of hospice –The percentage of older people who received hospice care in the last 30 days of life increased from 19 percent in 1999 to 43 percent in 2009. The percentage of older Americans who died in hospitals dropped from 49 percent in 1999 to 32 percent in 2009. The percentage who died at home increased from 15 percent in 1999 to 24 percent in 2009. In 2009, there were notable differences in the use of hospice services at the end of life among people of different race and ethnicity groups.

Older Americans 2012: Key Indicators of Well-Being is available online at http://www.agingstats.gov.

The Federal Interagency Forum on Aging-Related Statistics was established in 1986 to improve the quality and utility of federal data on aging. This report assembles data to construct broad indicators of well-being for the older population and to monitor changes in these indicators over time. The effort is designed to inform the public, policy makers, and researchers about important trends in the aging population. The 15 agencies represented in the Forum include the Administration on Aging, Agency for Healthcare Research and Quality, Bureau of Labor Statistics, Centers for Medicare & Medicaid Services, U.S. Census Bureau, Department of Housing and Urban Development, Department of Veterans Affairs, Employee Benefits Security Administration, Environmental Protection Agency, National Center for Health Statistics, National Institute on Aging, Office of Management and Budget, Office of the Assistant Secretary for Planning and Evaluation (Department of Health and Human Services), Social Security Administration and Substance Abuse and Mental Health Services Administration.

Older Americans 2012: Key Indicators of Well-Being is available online at http://www.agingstats.gov and in limited quantities in print. Supporting data for each indicator, including complete tables, PowerPoint slides and source descriptions, can be found on the Forum’s website. Single printed copies of Older Americans 2012: Key Indicators of Well-Being are available at no charge through the National Center for Health Statistics while supplies last. Requests may be made by calling 1-866-441-6247 or by sending an e-mail to nchsquery@cdc.gov. For multiple print copies, call 301-458-4460 or send an e-mail request to agingforum@cdc.gov.

###

The following individuals are available to comment on the report:

National Center for Health Statistics:
Edward Sondik, Ph.D., director, National Center for Health Statistics

National Institute on Aging:
Richard Suzman, Ph.D., director, NIA Division of Behavioral and Social Research

To schedule interviews, please contact:

NCHS Press Office: 301-458-4800, paoquery@cdc.gov
N
IA Press Office: 301-496-1752; nianews3@mail.nih.gov

St. Jude Medical Riata Implantable Cardioverter Defibrillator ICD Leads – Premature Insulation Failure

ISSUE: The Food and Drug Administration FDA is providing information and recommendations regarding safety concerns with the recalled Riata leads. These leads have an increased risk of premature insulation failure that can impact the lead’s ability to function properly.

 

According to St. Jude Medical, as of 2011, approximately 79,000 Riata leads remained implanted in patients in the United States.

via Safety Alerts for Human Medical Products > St. Jude Medical Riata Implantable Cardioverter Defibrillator ICD Leads: Safety Communication – Premature Insulation Failure.

Bear this in mind when you’re underwriting pacemaker cases.

Seniors May See Brain Shift from Vessel Ischemia

The bright white spots that show up on brain scans in older people may be a manifestation of disease and not just a benign byproduct of aging, according to a prospective study.

Leukoaraiosis is the radiologic term for nonspecific white matter T2 signal hyperintensities that show up on structural brain MRI. Also known as small vessel ischemia, the bright spots are thought to be the result of microangiopathic damage and their clinical importance has been debated.

via Seniors May See Brain Shift from Vessel Ischemia.