Mealtime can provide opportunities to connect with someone experiencing memory loss and tap into deeply rooted memories. “If you’re going to make your father’s favorite meal, think about how you can delve into it as an experience,” Aguirre says. Dr. Kramer notes that several senses associated with cooking and eating dishes, including smell and taste, are closely related to memory. Both the olfactory bulb, the main receiving center for smell, and the insular cortex and frontal operculum (also called the gustatory cortex), responsible for perception of taste, are closely connected to the amygdala, an area involved in emotional learning. The olfactory nerve, which conveys the sense of smell to the brain, is also close to the hippocampus, one of the most important brain structures for memory. And the combined effect of smell and taste—what neuroscientists who study this field call “flavor”—can be especially powerful at conjuring long-held memories charged with emotion, says Joel Salinas, MD, MBA, FAAN, assistant professor of neurology at NYU Langone Health and chief medical officer at Isaac Health, a clinic in New York City for brain health and memory problems.Favorite Meals May Trigger Memories in People with Dementia – https://www.brainandlife.org/articles/food-may-trigger-memories-in-people-with-dementia
Neurobiology
Researchers Have Mapped all 139,255 Neurons in the Brain of an adult fruit fly
An adult fruit fly’s brain is much more complex, however—and most importantly, the small insects share 60 percent of human DNA, as well 75 percent of the genes that cause genetic diseases, per a statement. As such, understanding the fly’s brain in such detail could hold implications for connections in human brains—and the neural pathways that lead to certain behaviors. Fruit flies, like humans, can get drunk, sing and be kept awake with coffee, suggesting similarities in our brains. https://www.smithsonianmag.com/smart-news/scientists-unveil-the-first-ever-complete-map-of-an-adult-fruit-flys-brain-captured-in-stunning-detail-180985191/
An actuary, an underwriter and a fruit fly walk into a bar…
It May Look Like I’m Not Doing Anything But I’m Actually in Default Mode
The default mode was one of the first brain networks characterized by science. It consists of a handful of brain regions, including a few at the front of the brain, like the dorsal and ventral medial prefrontal cortices, and others scattered throughout the organ, like the posterior cingulate cortex, the precuneus and the angular gyrus. These regions are associated with memory, experience replay, prediction, action consideration, reward/punishment and information integration…
According to research, the effects of the default mode network include mind wandering, remembering past experiences, thinking about others’ mental states, envisioning the future and processing language. While this may seem like a grab bag of unrelated aspects of cognition, Vinod Menon, the director of the Stanford Cognitive & Systems Neuroscience Laboratory, recently theorized that all of these functions may be helpful in constructing an internal narrative. In his view, the default mode network helps you think about who you are in relation to others, recall your past experiences and then wrap up all of that into a coherent self-narrative.
What Your Brain Is Doing When You’re Not Doing Anything — https://www.quantamagazine.org/what-your-brain-is-doing-when-youre-not-doing-anything-20240205
Great article.
But Both Are Legal…right? – Updated
“We found that alcohol and THC together significantly reduced, and in some cases prevented, the ability of the prefrontal cortex in drug-exposed rats to undergo plasticity in the same way that the brains from control animals can,” said Linyuan Shi, a graduate student in the Gulley lab. “The effects were apparent in rats exposed to either drug alone, and they were most pronounced with co-exposure to both drugs. We also found the impaired plasticity was likely due to changes in signaling caused by gamma-aminobutyric acid, a chemical messenger in the brain. When we used a chemical that enhances GABA, it could rescue the deficits we saw in the animals that had been exposed to the drugs.”
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign. “Combined use of alcohol and THC can affect rat brains, study finds.” ScienceDaily. ScienceDaily, 30 November 2023 — https://www.sciencedaily.com/releases/2023/11/231130121946.htm
I’m glad I am not a rat.
Young adults who simultaneously use alcohol and marijuana (SAM) consume more drinks, are high for more hours in the day, and report more negative alcohol-related consequences.
On SAM use days, participants consumed an average of 37% more drinks, with 43% more negative alcohol consequences, were high for 10% more hours, and were more likely to feel clumsy or dizzy, compared with non-SAM use days.
Simultaneous Marijuana, Alcohol Use Linked to Worse Outcomes — https://www.medscape.com/viewarticle/996595?icd=login_success_gg_match_norm&isSocial
Hmmm…
But Both Are Legal…right?
“We found that alcohol and THC together significantly reduced, and in some cases prevented, the ability of the prefrontal cortex in drug-exposed rats to undergo plasticity in the same way that the brains from control animals can,” said Linyuan Shi, a graduate student in the Gulley lab. “The effects were apparent in rats exposed to either drug alone, and they were most pronounced with co-exposure to both drugs. We also found the impaired plasticity was likely due to changes in signaling caused by gamma-aminobutyric acid, a chemical messenger in the brain. When we used a chemical that enhances GABA, it could rescue the deficits we saw in the animals that had been exposed to the drugs.”
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign. “Combined use of alcohol and THC can affect rat brains, study finds.” ScienceDaily. ScienceDaily, 30 November 2023 — https://www.sciencedaily.com/releases/2023/11/231130121946.htm
I’m glad I am not a rat.
Take a Break – 04.19.23 (let’s do some brain remodeling)
A study led by the UNIGE, HES-SO Geneva, and EPFL revealed that music practice and active listening could prevent working memory decline. Such activities promoted brain plasticity, they were associated with grey matter volume increase. Positive impacts have also been measured on working memory. This study was conducted among 132 healthy retirees from 62 to 78 years of age. One of the conditions for participation was that they had not taken any music lessons for more than six months in their lives…The participants were randomly assigned to two groups, regardless of their motivation to play an instrument. The second group had active listening lessons, which focused on instrument recognition and analysis of musical properties in a wide range of musical styles. The classes lasted one hour. Participants in both groups were required to do homework for half an hour a day.”
After six months, we found common effects for both interventions. Neuroimaging revealed an increase in grey matter in four brain regions involved in high-level cognitive functioning in all participants, including cerebellum areas involved in working memory. Their performance increased by 6% and this result was directly correlated to the plasticity of the cerebellum,” says Clara James, last author of the study, a privat-docent at the Faculty of Psychology and Educational Sciences of UNIGE, and full professor at the Geneva School of Health Sciences
Université de Genève. “How music can prevent cognitive decline.” ScienceDaily. http://www.sciencedaily.com/releases/2023/04/230417142520.htm (accessed April 18, 2023).
Journal Reference – Damien Marie, Cécile A.H. Müller, Eckart Altenmüller, Dimitri Van De Ville, Kristin Jünemann, Daniel S. Scholz, Tillmann H.C. Krüger, Florian Worschech, Matthias Kliegel, Christopher Sinke, Clara E. James. Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy. Neuroimage: Reports, 2023; 3 (2): 100166 DOI: 10.1016/j.ynirp.2023.100166
I could feel my brain grey matter volume increasing when listening to this album.
Dieting: Brain amplifies signal of hunger synapses (in mice)
The researchers put mice on a diet and assessed which circuits in the brain changed. In particular, they examined a group of neurons in the hypothalamus, the AgRP neurons, which are known to control the feeling of hunger. They were able to show that the neuronal pathways that stimulate AgRP neurons sent increased signals when the mice were on a diet. This profound change in the brain could be detected for a long time after the diet.
Max Planck Institute for Biology of Ageing. “Dieting: Brain amplifies signal of hunger synapses: Possible target for drugs to combat the yo-yo effect.” ScienceDaily. http://www.sciencedaily.com/releases/2023/03/230324135218.htm (accessed March 28, 2023).
Exercise Alters Brain Chemistry – May Protect Aging Synapses
When elderly people stay active, their brains have more of a class of proteins that enhances the connections between neurons to maintain healthy cognition.
University of California – San Francisco. “Exercise alters brain chemistry to protect aging synapses: Enhanced nerve transmission seen in older adults who remained active.” ScienceDaily. http://www.sciencedaily.com/releases/2022/01/220107100955.htm (accessed January 8, 2022).
I was about to write a snarky comment but I forgot what it was.
Journal Reference – Kaitlin Casaletto, Alfredo Ramos‐Miguel, Anna VandeBunte, Molly Memel, Aron Buchman, David Bennett, William Honer. Late‐life physical activity relates to brain tissue synaptic integrity markers in older adults. Alzheimer’s & Dementia, 2022; DOI: 10.1002/alz.12530
The Incentive Salience Theory – Kent Berridge
How is everyone’s Sunday morning going? I’m learning more about incentive salience theory. Old video but still quite informative.
lifeunderwriter.net 