FDA Warns Against Combining Alcohol, Other CNS Depressants With Xyrem – AAFP News

According to the Dec. 17 statement, the FDA recently evaluated reports of patients who died while taking Xyrem — which is used to reduce instances of cataplexy and to manage other symptoms of narcolepsy — along with alcohol or other central nervous system (CNS) depressants. Although the precise cause of the deaths remains uncertain — the reports contained incomplete information and did not adequately address confounding factors, such as pre-existing sleep apnea and/or chronic obstructive pulmonary disease — given some of the circumstances noted in the deaths, the FDA determined that the recommendations in the Xyrem drug label should be strengthened to highlight the risks of using the drug in conjunction with CNS depressant drugs or alcohol.

via FDA Warns Against Combining Alcohol, Other CNS Depressants With Xyrem — AAFP News Now — AAFP.

Oops.

U-Shaped Link for BMI at DX With Mortality in DM2

U-Shaped Link for BMI at Diagnosis With Mortality in Type 2 Diabetes | insureintell.com.

CONCLUSIONS Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight-loss interventions reduce mortality in all T2DM patients requires study.

via The Association Between BMI Measured Within a Year After Diagnosis of Type 2 Diabetes and Mortality.

HT – Hank George

Simple Sit Test Predicts Long Life

This study evaluated the association between the ability to sit and rise from the floor with and without support and all-cause mortality in adults age 51 to 80.

There was a significant association between the use of more support to sit and rise from the floor and increasing all-cause mortality.

via Simple Sit Test Predicts Long Life.

Our profession typically uses chair-to-stand testing as part of a senior supplement.  Should we be considering the use of the sit-rise test instead?