BBC News – Lack of sleep ‘linked to early death’
Getting less than six hours sleep a night can lead to an early grave, UK and Italian researchers have warned.
They said people regularly having such little sleep were 12% more likely to die over a 25-year period than those who got an “ideal” six to eight hours.
On-the-job pressure significantly increases the likelihood that women will develop ischemic heart disease, a large Danish study found.
Compared with women who felt their workplace pressure was suitable, those who reported that the pressure was much too high had a nearly 50% increased risk of developing ischemic heart disease (HR 1.47, 95% CI 1.14 to 1.88), according to Karen Allesøe, PhD, and colleagues from Glostrup University Hospital.
The diagnosis of radiographic osteoarthritis in one knee or hip likely signals the involvement of the contralateral joint, a cross-sectional analysis determined.
In a patient with moderate-to-severe osteoarthritis in one knee, the odds ratio for having a similar degree of involvement of the other knee was 62.7 (95% CI 42.3 to 93.1), according to Eric C. Sayre, PhD, of the University of British Columbia in Vancouver, and colleagues.
Ouch.
High levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) were an independent risk factor for non-vascular mortality as well as for cardiovascular death, stroke, and coronary heart disease in a large meta-analysis.
For each standard deviation above the mean for Lp-PLA2 among nearly 80,000 participants in 32 prospective studies, the risk of non-vascular death increased by 10% after adjusting for conventional risk factors, reported Alexander Thompson, of the University of Cambridge in England, and 14 other members of the Lp-PLA2 Studies Collaboration in the May 1 Lancet.
One Volcano, 4 Friends, and Many Career Ideas | paulacaligiuri.com
Opportunities, even those that change your plans in unexpected ways, may be exactly the ones that will help move your career – and your life – in a wonderful direction.
Attitude. And I’ll keep posting about this so that it sinks in and sticks.
Koilonychia are spoon shaped nails.
Results: The study identified 26 completed suicides, 801 attempted suicides, and 41 violent deaths in 297 620 new episodes of treatment with an anticonvulsant (overall median follow-up, 60 days). The incidence of the composite outcomes of completed suicides, attempted suicides, and violent deaths for anticonvulsants used in at least 100 treatment episodes ranged from 6.2 per 1000 person-years for primidone to 34.3 per 1000 person-years for oxcarbazepine. The risk of suicidal acts was increased for gabapentin (hazard ratio [HR], 1.42; 95% confidence interval [CI], 1.11-1.80), lamotrigine (HR, 1.84; 95% CI, 1.43-2.37), oxcarbazepine (HR, 2.07; 95% CI, 1.52-2.80), tiagabine (HR, 2.41; 95% CI, 1.65-3.52), and valproate (HR, 1.65; 95% CI, 1.25-2.19), compared with topiramate. The analyses including violent death produced similar results. Gabapentin users had increased risk in subgroups of younger and older patients, patients with mood disorders, and patients with epilepsy or seizure when compared with carbamazepine.
Conclusion: This exploratory analysis suggests that the use of gabapentin, lamotrigine, oxcarbazepine, and tiagabine, compared with the use of topiramate, may be associated with an increased risk of suicidal acts or violent deaths.
Conclusion: In this multi-ethnic cohort, addition of CACS to a prediction model based on traditional risk factors significantly improved the classification of risk and placed more individuals in the most extreme risk categories.
The effect of combined health behaviors was strongest for other deaths and weakest for cancer mortality. Those with 4 compared with those with no poor health behaviors had an all-cause mortality risk equivalent to being 12 years older.
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