Neurotonin – Watch Off-label Usage

Pfizer Agrees to First Neurontin Lawsuit Settlement (Update1) – Bloomberg.com

Pfizer faces more than 1,000 lawsuits accusing it of illegally promoting Neurontin for unapproved uses and helping to cause some users’ suicides. The settlement comes a week after another Boston jury ordered Pfizer to pay more than $140 million in damages to an insurer over the drug. Pfizer has denied any wrongdoing in connection with its handling of Neurontin.

High Dose Simvastatin = Muscle Injury Risk

Zocor (simvastatin): increased risk of muscle injury with high doses

FDA notified healthcare professionals and patients that, based on review of data from a large clinical trial and other sources, there is an increased risk of muscle injury in patients taking the highest approved dose of the cholesterol-lowering medication, Zocor (simvastatin) 80 mg, compared to patients taking lower doses of simvastatin and possibly other drugs in the “statin” class. FDA is also reviewing data from other clinical trials, observational studies, adverse event reports, and data on prescription use of simvastatin to better understand the relationship between high-dose simvastatin use and muscle injury.

Mild Hyperparathyroidism = Higher All Cause Mortality

Medical News: BES: ‘Mild’ Parathyroid Disease Poses Mortality Risk – in Meeting Coverage, BES from MedPage Today

Compared with the general population, the relative risk of all-cause mortality in patients with clinically minimal hyperparathyroidism was 2.62 (95% CI 2.39 to 2.86) in a population-based study, according to Graham Leese, MD, of the University of Dundee in Scotland.

Undiagnosed CKD in Prediabetes

Medical News: Kidney Disease Common in Undiagnosed and Prediabetes – in Nephrology, General Nephrology from MedPage Today

More than 40% of people with undiagnosed diabetes had chronic kidney disease, based on albuminuria or reduced estimated glomerular filtration rate (eGFR) — just as many as in those with diagnosed diabetes, according to Laura C. Plantinga, ScM, of San Francisco General Hospital and University of California San Francisco, and colleagues.

Notably, 56.2% of chronic kidney disease was stage 3 or 4 among those with prediabetes, indicated by a fasting plasma glucose between 100 and 126 mg/dl, and for whom kidney dysfunction was likely unsuspected.

ASTD Report – New Factors Compound the Growing Skills Shortage

February 2010 Bridging Skills Gap – Free – ASTD

Click on the link above and you’ll be taken to the original source article for the statistics provided below.  The charts themselves came from a newsletter called Workforce Training.  The percentages in bold are my emphasis.  Scary statistics but fixable.

Did I mention we conduct skills gap analysis and custom training to address the gaps?

SKILL GAPS
Seventy-nine percent of 1,179 companies surveyed by the American Society for Training & Development said they had a skill gap. The respondents listed their highest priority gaps as:
Skills of the current workforce do not match changes in company strategy, goals, markets or business models: 51%
Not enough bench strength in the company’s leadership ranks: 40%
Recent merger/acquisition where the organization brought in new employees or current employees are not up to speed on the new industry: 35
Training investments have been cut or there is lack of commitment by senior leaders to employee learning and development: 27
When hiring for certain types of jobs, there are too few qualified candidates (i.e., a gap in the pipeline): 25%
Lack of skilled talent in one or more of the company’s lines of business: 21%
Source: “Bridging the Skills Gap,” American Society for Training & Development, 2009
WHERE THE GAPS ARE
The same companies listed these as their greatest skill needs:
Leadership/executive level skills: 50%
Basic skills (traditional building blocks of business-level competencies): 46%
Professional or industry-specific skills: 41%
Managerial/supervisory skills: 31
Customer service skills: 31
Communication/interpersonal skills: 31
Technical/IT/systems skills: 30
Sales skills: 30
Process and project management skills: 20
Other: 43
Source: “Bridging the Skills Gap,” American Society for Training & Development, 2009

Stay Active Stay Healthy

Arch Intern Med — Abstract: Physical Activity at Midlife in Relation to Successful Survival in Women at Age 70 Years or Older, January 25, 2010, Sun et al. 170 (2): 194

Methods – A total of 13 535 Nurses’ Health Study participants who were free of major chronic diseases at baseline in 1986 and had survived to age 70 years or older as of the 1995-2001 period made up the study population. We defined successful survival as no history of 10 major chronic diseases or coronary artery bypass graft surgery and no cognitive impairment, physical impairment, or mental health limitations.

Conclusion – These data provide evidence that higher levels of midlife physical activity are associated with exceptional health status among women who survive to older ages and corroborate the potential role of physical activity in improving overall health.