Obstructive Sleep Apnea, Atrial Fibrillation, and Stroke | Physician’s Weekly

Researchers in Connecticut have found that obstructive sleep apnea (OSA) in patients with atrial fibrillation (AF) appears to be an independent predictor of stroke.

via Obstructive Sleep Apnea, Atrial Fibrillation, and Stroke | Physician’s Weekly.

Sleep Apnea Linked to Cancer

Sleep Apnea Linked to Cancer.

Moderate-to-severe OSA was associated with a 2.5-fold higher likelihood of incident cancer (95% CI 1.2-5.0) after adjustment for obesity and a full range of other factors, Nathaniel Marshall, PhD, of the University of Sydney Nursing School in Australia, and colleagues found.

Cancer mortality was 3.4 times more common (95% CI 1.1-10.2) in those with sleep apnea than with no sleep apnea during 20 years of follow-up, they reported in the April 15 issue of theJournal of Clinical Sleep Medicine.

Obstructive Sleep Apnea and Diabetic Nephropathy

OSA is independently associated with DN in type 2 diabetes. eGFR declined faster in patients with OSA. Nitrosative stress may provide a pathogenetic link between OSA and DN. Interventional studies assessing the impact of OSA treatment on DN are needed.

via Obstructive Sleep Apnea and Diabetic Nephropathy.

Sleep Apnea Plays Role in Car Crashes

An estimated 20% to 50% of commercial drivers have sleep apnea. That high proportion may be in part due to the sedentary nature of long-haul trucking that contributes to obesity as a risk factor for sleep apnea, according to a statement from the American Academy of Sleep Medicine in support of federal legislation.

via Sleep Apnea Plays Role in Car Crashes.

Presented without the usual caustic comment.

Sleep Apnea Severity Tied to Cardiac Marker

  • Obstructive sleep apnea is associated with cardiovascular morbidity and mortality, particularly heart failure, a study found.
  • The severity of obstructive sleep apnea was significantly associated with higher levels of high-sensitivity troponin, suggesting that subclinical myocardial injury may play a role in the association with risk of heart failure.

via Sleep Apnea Severity Tied to Cardiac Marker.

Apnea: ‘Sleeping Gun’ in Sudden Death?

After adjustment for other risk factors, each 10% decrease in the lowest nocturnal oxygen saturation among adults undergoing a first-time polysomnogram for suspected sleep-disordered breathing was associated with a 14% greater risk of sudden cardiac death or resuscitated cardiac arrest (HR 1.14, 95% CI 1.01 to 1.27), according to Virend Somers, MD, PhD, of the Mayo Clinic in Rochester, Minn., and colleagues.

Sleep factors associated with a significantly greater likelihood of remaining free from sudden cardiac death or resuscitated cardiac arrest included an apnea-hypopnea index of less than 20 events per hour (HR 1.60, 95% CI 1.14-2.24), a mean nocturnal oxygen saturation of 93% or higher (HR 2.93, 95% CI 1.98-4.33), and a lowest nocturnal oxygen saturation of 78% or higher (HR 1.81, 95% CI 1.28-2.56), the researchers reported online in the Journal of the American College of Cardiology.

via Apnea: ‘Sleeping Gun’ in Sudden Death

Yes.  CPAP compliance matters.