Arch Intern Med — Abstract: Heavy Smoking in Midlife and Long-term Risk of Alzheimer Disease and Vascular Dementia, October 25, 2010, Rusanen et al. 0 (2010): archinternmed.2010.393v1

Conclusions – In this large cohort, heavy smoking in midlife was associated with a greater than 100% increase in risk of dementia, AD, and VaD more than 2 decades later. These results suggest that the brain is not immune to long-term consequences of heavy smoking.