Results 60 174 individuals were identified; 4.7% of the periodontitis participants (455/9730) and 1.9% of the non-periodontitis participants (962/50 444) reported ACVD; periodontitis showed a significant association with ACVD (OR 2.52; 95% CI 2.3 to 2.8). After adjustment for the confounders, periodontitis remained independently associated with ACVD (OR 1.59; 95% CI 1.39 to 1.81). With subsequent stratification for age and sex, periodontitis remained independently associated with ACVD.
Rocky Mountain Spotted Fever is potentially deadly, but may initially appear similar to benign illness.
Scientific spammer PLOS ONE is an ongoing source of amusement. It’s peer review is regularly called into question, with the journal accepting unscientific papers.
Source: Ongoing Questions about PLOS ONE’s Peer Review | Scholarly Open Access
Source: Diabetes Drugs: The Latest Good — and Bad — News
Six minute video.
The researchers found that for each year the teens engaged in weekly marijuana use, their level of subsequent subclinical psychotic symptoms rose by 21%. The increase was greatest for paranoia (133%) and hallucinations (92%).
Source: Marijuana Tied to Ongoing, Subclinical Psychosis in Teens
Legal does not equal safe.
For the first time in modern history, the most common living arrangement for young adults is living in their parents’ homes. But where is the practice most common?
Source: Where Millennials Are More Likely to Live With Mom and Dad
Certainly tobacco products are dangerous to children’s health, but what about the new rage, Vape? Can liquid nicotine be dangerous?
Results – 41 papers representing 19 observational cohort studies and 17 clinical trial cohorts, comprising 46 separate analyses were identified. Long term variability in blood pressure was studied in 24 papers, mid-term in four, and short-term in 15 (two studied both long term and short term variability). Results from 23 analyses were excluded from main analyses owing to high risks of confounding. Increased long term variability in systolic blood pressure was associated with risk of all cause mortality (hazard ratio 1.15, 95% confidence interval 1.09 to 1.22), cardiovascular disease mortality (1.18, 1.09 to 1.28), cardiovascular disease events (1.18, 1.07 to 1.30), coronary heart disease (1.10, 1.04 to 1.16), and stroke (1.15, 1.04 to 1.27). Increased mid-term and short term variability in daytime systolic blood pressure were also associated with all cause mortality (1.15, 1.06 to 1.26 and 1.10, 1.04 to 1.16, respectively).
Conclusions – Long term variability in blood pressure is associated with cardiovascular and mortality outcomes, over and above the effect of mean blood pressure. Associations are similar in magnitude to those of cholesterol measures with cardiovascular disease. Limited data for mid-term and short term variability showed similar associations. Future work should focus on the clinical implications of assessment of variability in blood pressure and avoid the common confounding pitfalls observed to date.
Source: Blood pressure variability and cardiovascular disease: systematic review and meta-analysis | The BMJ
Source: Letter | Letter Project | Stanford Medicine
It took less than 30 minutes to prepare my advance directives along with a letter to my doctor. I have to get the document signed and witnessed but I’m pretty much done. Don’t delay, do this today.
Conclusions: Our findings suggest that impairments in cerebral white matter, even at early stages, are not limited to adverse brain outcomes and they are related to mortality, especially from cardiovascular causes.
Source: Lower microstructural integrity of brain white matter is related to higher mortality
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