Dig Deeper – PCSK9 Inhibitors

I’ve cut and pasted an email from Health After 50, a free newsletter from Scientific American.  My first thought was dig deeper.  The uninformed masses might take this information to their physician and start creating demand for these drugs.  Would you be surprised that the cost could be as high as $1000.00 per month?

In The Debate About Cost And Efficacy, PCSK9 Inhibitors May Be The Biggest Challenge Yet

PCSK9 Inhibitors: The Needle, the Cost, the Barriers | Medpage Today

There are still some highly effective generic statins where $10.00 buys you a 90 day supply.  There are OTC options to help with muscle pain and cramps.  You have to ask what good will these new drugs do if no one can afford them?

God Bless America.  We now have PCSK9 (proprotein convertase subtilisin/kexin 9) inhibitors.

The Promising Alternative to Statins

Every so often medication comes along that sends the world of medicine’s collective heart aflutter. Cholesterol-lowering newcomers alirocumab (Praluent) and evolocumab (Repatha) are the current favorites.

Both medications are part of a new class of drugs called PCSK9 inhibitors. As the “inhibitor” in the name implies, these drugs work by inhibiting proprotein convertase subtilisin/kexin 9, a protein that makes it more difficult for the liver to remove cholesterol. By blocking this substance, the medication is able to lower the LDL cholesterol circulating in the blood. In clinical trials, PCSK9 inhibitors have been shown to lower LDL levels significantly beyond what can be achieved with statin drugs, which have been the standard cholesterol-lowering therapy for more than two decades. And they did so without the most common side effect of statins: muscle pain.

Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies | The BMJ

Source: Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies | The BMJ

Conclusions Saturated fats are not associated with all cause mortality, CVD, CHD, ischemic stroke, or type 2 diabetes, but the evidence is heterogeneous with methodological limitations. Trans fats are associated with all cause mortality, total CHD, and CHD mortality, probably because of higher levels of intake of industrial trans fats than ruminant trans fats. Dietary guidelines must carefully consider the health effects of recommendations for alternative macronutrients to replace trans fats and saturated fats.

This is what 365 days without a vacation does to your health

Source: This is what 365 days without a vacation does to your health

One week ago we were hiking the mountains in and around Aspen Colorado.  It was a glorious getaway surrounded by gorgeous natural beauty.  Our MGS (mountain goat son)  gave us a glimpse into his new life, living and working in the Roaring Fork Valley.  The original plan was to spend a long Labor Day weekend with MGS but he had other plans.  Right now he’s in Utah on a kayak and camping trip with friends from work.

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It’s all about balance.  When working, work your ass off.  When you’re not working, make damn sure you truly take time off to pursue whatever you find enjoyable and forget totally about work.  Disconnect!!!  Leave all of your inconvenient 24/7 devices at home.  The emails can wait until you get back.

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One of the life lessons I’ve passed along to MSG and his brother RocDoc came in the form of a question.  Be brutally honest and ask yourself this:

Do you live to work or do you work to live?

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