Although the FDA review discounted an excess bleeding risk with dabigatran, it did not address another potential concern — the ability to reverse the anticoagulant effect acutely in cases of emergency.
Antman acknowledged that there is no specific, approved antidote for dabigatran or any of the novel anticoagulants, although it is an area of active investigation and the topic of several studies that will be presented at the AHA meeting in the coming days.
He said it’s not true, however, that clinicians don’t have any options. Intravenous administration of blood coagulation factors — prothrombin complex concentrates that are available in every hospital — can help to reverse the effect, though not completely.
In comparison, the effects of warfarin can be reversed with the administration of vitamin K. Antman noted. But that that doesn’t always work either, and patients can die because of it, he added.
Author: SupremeCmdr
Oklahoma City – Medical Tourism Destination
MetLife’s Big Annuity Charge Linked to Regulatory Concern – WSJ.com
Hartford Offers Buyouts to Annuity Clients to Trim Risk – Bloomberg
Hartford Offers Buyouts to Annuity Clients to Trim Risk – Bloomberg.
Time will tell if anyone sells their contracts back.
37signals Earns Millions Each Year. Its CEO’s Model? His Cleaning Lady – Fast Company
She’s on her own, she cleans people’s homes, she’s incredibly nice. She brings flowers every time she cleans, and she’s just respectful and nice and awesome. Why can’t more people be like that? She’s been doing it some twenty-odd years, and that’s just an incredible success story. To me that’s far more interesting than a tech company that’s hiring a bunch of people, just got their fourth round of financing for 12 million dollars, and they’re still losing money. That’s what everyone talks about as being exciting, but I think that’s an absolutely disgusting scenario when it comes to business.
via 37signals Earns Millions Each Year. Its CEO’s Model? His Cleaning Lady | Fast Company.
I loved this interview. You will too.
M&Ms Recruiting Test: How You Do Anything Is How You Do Everything
Twitter and Facebook ‘harming children’s development’ – Telegraph
A generation of children risks growing up with obsessive personalities, poor self-control, short attention spans and little empathy because of an addiction to social networking websites such as Twitter, a leading neuroscientist has warned.
Baroness Greenfield quoted figures showing that more than half of 13- to 17-year-olds now spend more than 30 hours a week using video games, computers, e-readers, mobile phones and other screen-based technology. She said the human brain evolved to its surroundings and needed a “stimulating environment” to grow and properly develop. But she warned that a reliance on social networking and increased use of computer games could effectively “rewire” the brain.
via Twitter and Facebook ‘harming children’s development’ – Telegraph.
Linzess – Think IBS with Constipation
Linzess is felt to act as a guanylate cyclase-C agonist. An agonist increases the activity of a process, the opposite of an antagonist. Linzess seems to act locally on the surface of the inside of the intestinal lining cells and by activation of guanylate cyclase-C increases levels of intracellular cGMP (cyclic guanosine monophosphate) which results in increased levels of chloride and bicarbonate in the intestinal lumen and speeds up gastrointestinal transit.
Man comes in with a chief complaint of poison ivy on his arm for several weeks. It’s getting better. I ask how I can help him.
Patient: I thought you could give me some Viagra for it.
Me: Um, Viagra isn’t going to do anything for your poison ivy.
Patient: It’ll take my mind off of it.
lifeunderwriter.net 
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