BMJ Group blogs: BMJ » Blog Archive » Richard Lehman’s journal review, 18 October 2010
Author: SupremeCmdr
If Your Leg Breaks Stop Taking Biphosphonates
The highlighted bold is me. I keep reading this FDA recommendation just to make sure I understand what they are trying to say. I think the recommendation says the FDA found no cause and effect between the use of biphosphonates and leg fractures so keep taking your medication. But if your leg breaks, your physician will instruct you to stop taking the medication she prescribed for you to help prevent bone loss and fractures.
I’m glad the FDA cleared up this issue, don’t you?
BACKGROUND: Atypical subtrochanteric femur fractures are fractures in the bone just below the hip joint. Diaphyseal femur fractures occur in the long part of the thigh bone. These fractures are very uncommon and appear to account for less than 1% of all hip and femur fractures overall. Although it is not clear if bisphosphonates are the cause, these unusual femur fractures have been predominantly reported in patients taking bisphosphonates.
RECOMMENDATIONS: Patients should continue to take their medication unless told to stop by their healthcare professional. FDA recommends that healthcare professionals should discontinue potent antiresorptive medications (including bisphosphonates) in patients who have evidence of a femoral shaft fracture. See the FDA Drug Safety Communication below for additional information.

ED and CHD Share Common Risk Factors
I have no further comment.
Background: ED and CAD share common risk factors which can result in endothelial dysfunction, atherosclerosis and flow-limiting stenoses in the coronary and internal pudendal arteries.

Watch, Listen and Learn – Medical Tourism in India
The video is less than four minutes long and gives you a sense of the current state of medical tourism.
Fascinating stuff.
You Are What You Are
Look AHEAD Clinical Trial
Pine Bark Extract for CHD – FAIL
Thinking Differently About Medications in the Elderly
Prostate Cancer Biomarker
The results, published in the Public Library of Science (PLoS) ONE journal, showed that MSMB is found at significantly lower levels in the urine of men diagnosed with prostate cancer than those without the disease. They also showed men with aggressive tumors were also likely to have lower levels of the protein in their urine.
Lehman’s Blog 10.11.2010
BMJ Group blogs: BMJ » Blog Archive » Richard Lehman’s journal review – 11 October 2010
Most medical research is clinically useless, and so, sadly, are most systematic reviews and meta-analyses.
The quote is from Lehman, not me.
You must be logged in to post a comment.