It’s not entirely clear how cannabis hyperemesis syndrome occurs though there are several theories. One is that since cannabinoids have long-half lives and are lipid soluble, they accumulate in the brain and over time cause symptoms, particularly in young people who may have genetic variations in enzymes which lead to further accumulation. Another theory is that there is a thermoregulatory and autonomic imbalance in the limbic system caused by chronic use. Other suggestions are that with long-term consumption cannabis becomes a receptor antagonist, or that they become down-regulated or de-sensitised over time. This reverses the antiemetic effect of cannabis. It seems that chronic over-stimulation of receptors leads to dysregulation of the body’s control of nausea and vomiting, leading to CHS.
In Mexico obesity reached epidemic proportions after it joined NAFTA with the United States and Canada in the early 1990s, making processed food more easily available. Diets quickly changed as many people, particularly those on lower incomes, replaced largely healthy traditional staples (corn tortilla, frijoles, Jamaica Water) with highly processed alternatives (hotdogs, nuggets, sodas). Sugar consumption soared and waistlines exploded. In the past 20 years the number of obese and overweight people has tripled, with 75% of the population now overweight.
Mexico also has the sixth highest mortality rate from Covid-19, which has spurred the government to escalate its war against obesity.
A new study out of the University of Chicago Medicine following young adult drinkers for 10 years has found that individuals who reported the highest sensitivity to alcohol’s pleasurable and rewarding effects at the start of the trial were more likely to develop an alcohol use disorder (AUD) over the course of the study.
University of Chicago Medical Center. “Increase in pleasurable effects of alcohol over time can predict alcohol use disorder: New research challenges existing dogma that higher tolerance for stimulating and rewarding effects of alcohol leads to addiction.” ScienceDaily. http://www.sciencedaily.com/releases/2021/01/210105084649.htm (accessed January 7, 2021).
Journal Reference: Andrea King, Ashley Vena, Deborah S. Hasin, Harriet deWit, Sean J. O’Connor, Dingcai Cao. Subjective Responses to Alcohol in the Development and Maintenance of Alcohol Use Disorder. American Journal of Psychiatry, 2021; appi.ajp.2020.2 DOI: 10.1176/appi.ajp.2020.20030247
Even under the best circumstances, however, addiction is a disease prone to relapse. An estimated 40-60% of people who misuse drugs will return to using them at some point during recovery—and it’s this time that leaves them most vulnerable to overdose, since their tolerance has dropped, often dramatically, during their period of abstinence.
Compared with participants who used less than 120 minutes per day of social media, for example, young adults who used more than 300 minutes per day were 2.8 times as likely to become depressed within six months.The study, which will be published online Dec. 10 and is scheduled for the February 2021 issue of the American Journal of Preventive Medicine, is the first large, national study to show a link between social media use and depression over time.
Brian A. Primack, Ariel Shensa, Jaime E. Sidani, César G. Escobar-Viera, Michael J. Fine. Temporal Associations Between Social Media Use and Depression. American Journal of Preventive Medicine, 2020; DOI: 10.1016/j.amepre.2020.09.014
The survey results are in line with recent data from Mental Health America, which indicate dramatic increases in depression, anxiety, and suicidality since the start of the COVID-19 pandemic.
Citation: Czeisler MÉ , Lane RI, Petrosky E, et al. Mental Health, Substance Use, and Suicidal Ideation During the COVID-19 Pandemic — United States, June 24–30, 2020. MMWR Morb Mortal Wkly Rep 2020;69:1049–1057. DOI: http://dx.doi.org/10.15585/mmwr.mm6932a1external icon.
Restaurant and bar owners worldwide are rapidly innovating to accommodate social distancing requirements in their establishments. One pub landlord has a crafty solution, and it’s positively … electric. Johnny McFadden, landlord of The Star Inn in Cornwall, England, installed an electric fence in his pub to maintain a safe distance between pub goers and his…
Nielsen reports alcohol sales in stores were up 54% in late March compared to that time last year, while online sales were up nearly 500% in late April. According to a Morning Consult poll of 2,200 U.S. adults conducted in early April, 16% of all adults said they were drinking more during the pandemic, with higher rates among younger adults: One in 4 Millennials and nearly 1 in 5 Gen Xers said they had upped their alcohol intake.
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