Compounding Compounds the Problem

Compound pharmacies that bulk produce weight-loss drugs without FDA approval are doing so without that oversight.  And because compounding pharmacies aren’t required to report instances of patient harm involving their medications, problems may go undetected.“It’s kind of like ‘Whack-A-Mole,’” said Al Carter, a pharmacist and executive director at the National Association of Boards of Pharmacy. He said state boards will only investigate when they receive a complaint.“There are bad actors out there, purporting to be compounding pharmacies that are licensed in specific states or have the credentials to be able to compound when in actuality they don’t,” said Carter. “My understanding is most licensed, legitimate pharmacies aren’t compounding” weight-loss medications. ‘Compounded’ weight-loss drugs are a growing problem for state regulatorshttps://stateline.org/2024/07/08/compounded-weight-loss-drugs-are-a-growing-problem-for-state-regulators/

A website sold patients obesity drugs at affordable rates. Now they’re paying the price.https://www.npr.org/2025/02/08/nx-s1-5246124/a-website-sold-patients-obesity-drugs-at-affordable-rates-now-theyre-paying-the-price

“The two main goals of the medication are weight loss and diabetes management, so patients should stay on the lowest dosage possible until they feel like they’ve plateaued,” said Charu Sawhney, DO, MPH, an internal medicine physician with Harbor Health in Round Rock, Texas. When patients move up on the dosage too fast, they’re going to have more trouble, said Sawhney. “This is when we see the most severe side effects like the malnutrition and dehydration that can sometimes land patients in the hospital,” she said. Considerations for Prescribing GLP-1s Get More Complicated – Medscape – February 07, 2025https://www.medscape.com/viewarticle/considerations-prescribing-glp-1s-get-more-complicated

I admit as a Former Fat Man that the world of obesity and now a miracle drug to fight the disease fascinates the hell out of me. Caveat emptor!

Fentanyl Facts

In 2022, according to provisional data from the Centers for Disease Control and Prevention (CDC), close to 83,000 people died from opioid overdoses in the United States, the majority from fentanyl and other highly potent synthetic substances. A Yale Medicine addiction medicine specialist discusses how the synthetic opioid became a problemhttps://www.yalemedicine.org/news/fentanyl-driving-overdoses

Meanwhile in Oklahoma…

Go here https://facingfentanylnow.org/fentanyl-facts/ for the facts.

Substance-Induced Psychosis Tied to Schizophrenia Risk

Individuals who visited the ER for substance-induced psychosis had a 160% greater risk of developing a schizophrenia spectrum disorder (SSD) compared with the general population, new research shows. Three years after an initial ER visit, 18.5% of those with substance-induced psychosis were diagnosed with an SSD. Cannabis-induced psychosis was associated with the greatest risk.

Eve Bender. Substance-Induced Psychosis Tied to Schizophrenia Risk – Medscape – Oct 04, 2023 – https://www.medscape.com/viewarticle/997093

Scary Charts – 08.20.23

There were 464 workplace fatalities from unintentional overdoses due to non-medical use of drugs or alcohol in 2021. This is a 19.6-percent increase from 2020 when there were 388 fatalities and is the ninth consecutive annual increase. Unintentional overdoses from non-medical use of drugs include overdoses from stimulants such as methamphetamine and from narcotics such as fentanyl.

Unintentional overdoses rose for the ninth consecutive year in 2021– https://www.bls.gov/opub/ted/2023/unintentional-overdoses-rose-for-the-ninth-consecutive-year-in-2021.htm

Source: Bureau of Labor Statistics, U.S. Department of Labor, The Economics Daily, Unintentional overdoses rose for the ninth consecutive year in 2021 at https://www.bls.gov/opub/ted/2023/unintentional-overdoses-rose-for-the-ninth-consecutive-year-in-2021.htm (visited August 20, 2023).

SARMs (Selective Androgen Receptor Modulators)

SARMs, which are chemical substances that mimic the effects of testosterone and anabolic steroids, are not FDA approved. Online vendors and social media influencers are using social media to make SARMs seem safe and effective.

The reality is SARMs are potentially dangerous. The FDA continues to receive adverse event reports associated with SARMS use. The real number of consumers experiencing adverse events is likely higher due to underreporting.  Because these are not approved drugs, consumers may be reluctant to report adverse events or may not be aware that they can report adverse events that they experience. In addition, they might not know that their symptoms are being caused by the product.

Studies and reports show SARMs are associated with serious or life-threatening health problems, such as:

  • Increased risk of heart attack or stroke
  • Psychosis/hallucinations    
  • Sleep disturbances
  • Sexual dysfunction 
  • Liver injury and acute liver failure 
  • Infertility
  • Pregnancy miscarriage
  • Testicular shrinkage 
FDA Warns of Use of Selective Androgen Receptor Modulators (SARMs) Among Teens, Young Adults — https://www.fda.gov/consumers/consumer-updates/fda-warns-use-selective-androgen-receptor-modulators-sarms-among-teens-young-adults

If you’ve read this far, congratulations. Now spread the word.

OD Deaths Involving Cocaine On The Rise

The rate of drug overdose deaths involving cocaine was stable between 2009 and 2013, then nearly tripled from 1.6 per 100,000 in 2013 to 4.5 in 2018.

NCHS Data Brief No. 384, October 2020 — https://www.cdc.gov/nchs/products/databriefs/db384.htm

Memo to all of my friends in the mortality risk business:

With so much attention being paid to Covid-19 it’s easy to forget people die from other causes. Don’t forget this.

The Other Drug Epidemic

Since 2011, emergency room visits related to meth in San Francisco have jumped 600% to 1,965 visits in 2016, the last year for which ER data is available. Admissions to the hospital are up 400% to 193, according to city public health data. And at San Francisco General Hospital, of 7,000 annual psychiatric emergency visits last year, 47% were people who were not necessarily mentally ill — they were high on meth.

Read the full article here.

 

Counterfeit Prescription Drugs Laced With Fentanyl Falling Into Unsuspecting Hands Thanks In Part To Social Media — Kaiser Health News

People buying drugs like Xanax online are taking the pills, not realizing that they are fake and some are tainted with a potent opioid. The mistake can be fatal. 26 more words

via Counterfeit Prescription Drugs Laced With Fentanyl Falling Into Unsuspecting Hands Thanks In Part To Social Media — Kaiser Health News