But Both Are Legal…right?

“We found that alcohol and THC together significantly reduced, and in some cases prevented, the ability of the prefrontal cortex in drug-exposed rats to undergo plasticity in the same way that the brains from control animals can,” said Linyuan Shi, a graduate student in the Gulley lab. “The effects were apparent in rats exposed to either drug alone, and they were most pronounced with co-exposure to both drugs. We also found the impaired plasticity was likely due to changes in signaling caused by gamma-aminobutyric acid, a chemical messenger in the brain. When we used a chemical that enhances GABA, it could rescue the deficits we saw in the animals that had been exposed to the drugs.”

Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign. “Combined use of alcohol and THC can affect rat brains, study finds.” ScienceDaily. ScienceDaily, 30 November 2023 — https://www.sciencedaily.com/releases/2023/11/231130121946.htm

I’m glad I am not a rat.

Substance-Induced Psychosis Tied to Schizophrenia Risk

Individuals who visited the ER for substance-induced psychosis had a 160% greater risk of developing a schizophrenia spectrum disorder (SSD) compared with the general population, new research shows. Three years after an initial ER visit, 18.5% of those with substance-induced psychosis were diagnosed with an SSD. Cannabis-induced psychosis was associated with the greatest risk.

Eve Bender. Substance-Induced Psychosis Tied to Schizophrenia Risk – Medscape – Oct 04, 2023 – https://www.medscape.com/viewarticle/997093

Scary Charts – 08.20.23

There were 464 workplace fatalities from unintentional overdoses due to non-medical use of drugs or alcohol in 2021. This is a 19.6-percent increase from 2020 when there were 388 fatalities and is the ninth consecutive annual increase. Unintentional overdoses from non-medical use of drugs include overdoses from stimulants such as methamphetamine and from narcotics such as fentanyl.

Unintentional overdoses rose for the ninth consecutive year in 2021– https://www.bls.gov/opub/ted/2023/unintentional-overdoses-rose-for-the-ninth-consecutive-year-in-2021.htm

Source: Bureau of Labor Statistics, U.S. Department of Labor, The Economics Daily, Unintentional overdoses rose for the ninth consecutive year in 2021 at https://www.bls.gov/opub/ted/2023/unintentional-overdoses-rose-for-the-ninth-consecutive-year-in-2021.htm (visited August 20, 2023).

Emphysema More Common in Marijuana Smokers Than Cigarette Smokers

“We know what cigarettes do to the lungs,” said study author Giselle Revah, M.D., a cardiothoracic radiologist and assistant professor at the University of Ottawa in Ottawa, Canada. “There are well researched and established findings of cigarette smoking on the lungs. Marijuana we know very little about.”

To find out more, Dr. Revah and colleagues compared chest CT results from 56 marijuana smokers with those of 57 non-smoking controls and 33 tobacco-only smokers.

Three-quarters of the marijuana smokers had emphysema, a lung disease that causes difficulty with breathing, compared with 67% of the tobacco-only smokers. Only 5% of the non-smokers had emphysema. Paraseptal emphysema, which damages the tiny ducts that connect to the air sacs in the lungs, was the predominant emphysema subtype in marijuana smokers compared to the tobacco-only group.

Radiological Society of North America. “Emphysema more common in marijuana smokers than cigarette smokers.” ScienceDaily. http://www.sciencedaily.com/releases/2022/11/221115113940.htm (originally accessed November 15, 2022).

Journal Reference

Luke Murtha, Paul Sathiadoss, Jean-Paul Salameh, Matthew D. F. Mcinnes, Giselle Revah. Chest CT Findings in Marijuana Smokers. Radiology, 2022; DOI: 10.1148/radiol.212611

The mean age of the MJ smokers in the study was 49.

The mean age of the tobacco smokers in the study was 60.

Oklahoma producing 64 times more marijuana than licensed users consume – The Oklahoman

“The supply-to-demand ratio of regulated medical marijuana supply to regulated medical cannabis demand is 64:1,” the report states. “Using a general assumption that units of supply should not exceed two times the units of demand, the medical marijuana program has no less than 32 times more regulated marijuana necessary than licensed patient demand.”

The significant oversupply is likely funneling large amounts of marijuana out of state and adding to the illegal market, according to authority officials.

Oklahoma producing 64 times more marijuana than licensed users consume, report shows — https://www.oklahoman.com/story/news/state/2023/06/21/marijuana-oklahoma-overproducing-64-times-omma-report/70343452007/

The Truth behind the medical marijuana industry.

At least we know there may be a positive longevity effect to all of this excess supply.

What the Scientists Who Pioneered Weight-Loss Drugs Want You to Know – Wired Magazine

What happens is that you lose your appetite and also the pleasure of eating, and so I think there’s a price to be paid when you do that. If you like food, then that pleasure is gone. The craving for food for some people is taken away when they take GLP-1 drugs.

So you don’t eat through GLP-1 therapy because you’ve lost interest in food. That may eventually be a problem, that once you’ve been on this for a year or two, life is so miserably boring that you can’t stand it any longer and you have to go back to your old life.

What the Scientists Who Pioneered Weight-Loss Drugs Want You to Know – https://www.wired.com/story/obesity-drugs-researcher-interview-ozempic-wegovy/

Just another GLP-1 receptor agonist post. See Tirzepatide (another GLP-1 receptor agonist post) for more on the new miracle weight loss drugs that were originally developed to treat duodenal ulcer disease (bet you thought it was diabetes).

The entire article is worth reading.

Drive By Truckers 2.0

Total drug violations reported into the clearinghouse in 2022, including positive tests and refusals to take a drug test, increased 18% to 69,668 compared with last year’s 59,011, according to the most recent statistics released this week by the Federal Motor Carrier Safety Administration. That rate almost doubled the 9.2% annual increase in drug violations reported in 2021. Much of the increase can be attributed to violations related to marijuana, the substance identified most in positive tests. Marijuana violations increased 31.6% in 2022 compared with 2021, to 40,916. That compares to a 5.3% increase between 2020 and 2021.

Truckers’ positive drug tests up 18% in 2022 — https://www.freightwaves.com/news/truckers-positive-drug-tests-up-18-in-2022

At least binge drinking prevalence is just 19%

Truck drivers have been reported as a highly vulnerable working population due to different risk factors [16,17,18] including hypertension, fatigue [19], obstructive sleep apnea (OSA) and sleep deprivation [20,21], and insufficient physical activity [22]. Other risk factors are exposure to diesel exhaust and risk of developing lung cancer [23], poor diet, obesity, dyslipidemia, and other metabolic disorders [24]. Furthermore, they are prone to risky behaviors and lifestyles such as smoking, drinking, using psychoactive substances, and having casual sexual contacts [25].

Patterns of Harmful Alcohol Consumption among Truck Drivers: Implications for Occupational Health and Work Safety from a Systematic Review and Meta-Analysis — Int J Environ Res Public Health. 2018 Jun; 15(6): 1121.
Published online 2018 May 30. doi: 10.3390/ijerph15061121

I ask them why the industry has a 90 percent attrition rate within the first year. All instantly respond: “No money.” They describe a predatory apprenticeship system that conspires against new drivers seeking to enter the profession. The industry is made up of thousands of mostly small-fleet owners—95 percent of them with 20 trucks or fewer—but dominated by about two dozen giant companies that serve as its gatekeepers. These megacarriers often house schools where some 400,000 new truckers receive commercial driver’s licenses annually. The companies entice people with promises of financial plenty, even as they ensnare them in “training contracts”—binding agreements that require them to drive for the company at below-market wages for a year in exchange for training or else be hit with an exorbitant fee for that training, to be paid off at high interest. Many drivers stick around for the full year to avoid those fees, enduring what amounts to debt peonage. 

“I have panic attacks,” he says. “That’s why I drink.”


Life as a 21st-Century Trucker — https://www.wired.com/story/life-as-a-21st-century-trucker/

For the first post in this series see Drive By Truckers.

Sharp Rise in Drug Overdose Deaths in Seniors

The researchers used data from the US Centers for Disease Control and Prevention (CDC) to calculate annual overdose deaths from 2002 to 2021 among people aged 65 and older.

Overall, they found that fatal overdoses quadrupled from 1060 in 2002 (three per 100,000) to 6702 (12 per 100,000) in 2021, with the highest rates in Blacks (30.9 per 100,000).

In 2021, about 13% of overdoses were intentional, 83% were unintentional, 4% were undetermined, and less than 1% were homicide. Older women accounted for 57% of intentional overdoses and 29% of accidental overdoses.

Sharp Rise in Drug Overdose Deaths in Seniors – Medscape – Mar 30, 2023 — https://www.medscape.com/viewarticle/990297?src=rss

FDA Approves First Over-the-Counter Naloxone Nasal Spray (Scary News or What?)

Drug overdose persists as a major public health issue in the United States, with more than 101,750 reported fatal overdoses occurring in the 12-month period ending in October 2022, primarily driven by synthetic opioids like illicit fentanyl.

FDA Approves First Over-the-Counter Naloxone Nasal Spray — https://www.fda.gov/news-events/press-announcements/fda-approves-first-over-counter-naloxone-nasal-spray