Audio. Annals On Call – Nonalcoholic Fatty Liver Disease: A Spectrum of Disorders: Dr. Centor discusses nonalcoholic fatty Liver disease with Dr. Meagan Gray, Assistant Professor of Medicine, University of Alabama.
Hepatology
Death Rate From Liver Cancer in US Now Double That in 1980s
Modifiable Risk Factors
Approximately 60% of all liver cancers in the United States are caused by potentially modifiable risk factors, the researchers indicate. For example, it has been estimated that among Medicare recipients, the largest proportion of cases of HCC, at 32%, are caused by metabolic disorders, including obesity. A smaller proportion of cases of HCC are caused by hepatitis C virus infection (21%), excessive alcohol intake (13%), and smoking (9%).
Source: Death Rate From Liver Cancer in US Now Double That in 1980s
Increased Mortality Tied to Fatty Liver Disease Spectrum | Medpage Today
Causes and Evaluation of Mildly Elevated Liver Transaminase Levels – American Family Physician
Causes and Evaluation of Mildly Elevated Liver Transaminase Levels – American Family Physician.
Nice article on the subject of mildly elevated liver enzymes.
Causes and Evaluation of Mildly Elevated Liver Transaminase Levels – American Family Physician
Acetaminophen Prescription Combination Drug Products with more than 325 mg: FDA Statement – Recommendation to Discontinue Prescribing and Dispensing
ISSUE: FDA is recommending health care professionals discontinue prescribing and dispensing prescription combination drug products that contain more than 325 milligrams (mg) of acetaminophen per tablet, capsule or other dosage unit. There are no available data to show that taking more than 325 mg of acetaminophen per dosage unit provides additional benefit that outweighs the added risks for liver injury. Further, limiting the amount of acetaminophen per dosage unit will reduce the risk of severe liver injury from inadvertent acetaminophen overdose, which can lead to liver failure, liver transplant, and death.
You like your liver? You can keep your liver.
Mass Destruction
ISSUE: The FDA is advising consumers to immediately stop using a product called Mass Destruction, marketed as a dietary supplement for muscle growth. The product is labeled to contain at least one synthetic anabolic steroid and has been linked to at least one reported serious illness.
BACKGROUND: The FDA was alerted by the North Carolina Department of Health and Human Services of a serious injury associated with use of Mass Destruction. The report described a previously healthy 28-year-old male with liver failure requiring transplant after several weeks of product use. Mass Destruction is manufactured for Blunt Force Nutrition in Sims, N.C. and sold in retail stores, fitness gyms, and on the Internet. An investigation is underway to identify the product’s manufacturer.
Finally a product that lives up to its name.
Acute Hepatitis and Liver Failure Following the Use of a Dietary Supplement Intended for Weight Loss or Muscle Building — May–October 2013
On September 9, 2013, the Hawaii Department of Health (HDOH) was notified of seven patients with severe acute hepatitis and fulminant liver failure of unknown etiology. Patients were previously healthy and sought medical care during May-September 2013. Clinicians reported that the seven patients had all used OxyELITE Pro, a dietary supplement marketed for weight loss and muscle gain, before illness onset.
Oops.
Vital Signs: Evaluation of Hepatitis C Virus Infection Testing and Reporting — Eight U.S. Sites, 2005–2011
Results: Of 217,755 persons newly reported, 107,209 (49.2%) were HCV antibody positive only, and 110,546 (50.8%) were reported with a positive HCV RNA result that confirmed current HCV infection. In both groups, persons were most likely to have been born during 1945–1965 (58.5% of those who were HCV antibody positive only; 67.2% of those who were HCV RNA positive). Among all persons newly reported for whom death data were available, 6,734 (3.4%) were known to have died; deaths were most likely among persons aged 50–59 years. In 2011, across all sites, the annual rate of persons newly reported with HCV infection (positive HCV antibody only and HCV RNA positive) was 84.7 per 100,000 population.
Hep C Drug Linked to Fatal Skin Reactions
The oral hepatitis C drug telaprevir (Incivek) will now carry a boxed warning about potentially fatal skin reactions in the wake of multiple deaths, its manufacturer said Wednesday.
via Hep C Drug Linked to Fatal Skin Reactions.
Oops.
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