Covid-19 and Young Adults – You Are Not Invincible (a gentle reminder)

Whistler recorded 1,120 COVID-19 cases from the beginning of January to March 28, with 218 of them last week alone, driven by the P.1 variant most commonly associated with Brazil. The majority of cases – 83.2 per cent – are in people aged 20 to 39.

Variant that forced B.C. ski resort shut is rapidly spreading, sending more young people to hospital — https://www.theglobeandmail.com/canada/article-covid-19-variant-spreading-rapidly-in-bc/

Young adults age 18 to 34 years hospitalized with COVID-19 experienced substantial rates of adverse outcomes: 21% required intensive care, 10% required mechanical ventilation, and 2.7% died. This in-hospital mortality rate is lower than that reported for older adults with COVID-19, but approximately double that of young adults with acute myocardial infarction.4 Morbid obesity, hypertension, and diabetes were common and associated with greater risks of adverse events. Young adults with more than 1 of these conditions faced risks comparable with those observed in middle-aged adults without them. More than half of these patients requiring hospitalization were Black or Hispanic, consistent with prior findings of disproportionate illness severity in these demographic groups.5,6

Clinical Outcomes in Young US Adults Hospitalized With COVID-19 — https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2770542

Please get vaccinated as soon as you’re eligible. This is a gentle reminder before I start getting a bit harsher with my messaging.

Covid-19 and Young Adults – You Are Not Invincible

Nice map from WAPO. Dr. Gandhi’s bird app post caught my eye. But for all you youngsters reading this it ain’t just Michigan.

Young adults age 18 to 34 years hospitalized with COVID-19 experienced substantial rates of adverse outcomes: 21% required intensive care, 10% required mechanical ventilation, and 2.7% died. This in-hospital mortality rate is lower than that reported for older adults with COVID-19, but approximately double that of young adults with acute myocardial infarction.4 Morbid obesity, hypertension, and diabetes were common and associated with greater risks of adverse events. Young adults with more than 1 of these conditions faced risks comparable with those observed in middle-aged adults without them. More than half of these patients requiring hospitalization were Black or Hispanic, consistent with prior findings of disproportionate illness severity in these demographic groups.5,6

Clinical Outcomes in Young US Adults Hospitalized With COVID-19 — https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2770542

No politics. No religion. No conspiracies. No bullshit. Please get vaccinated as soon as you’re eligible.

SARS-CoV-2 Variants – P.1 Arrives in Oklahoma

https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/variant-surveillance/variant-info.html

The map on the CDC website is interactive and will show different variants by state.

I don’t consider myself to be an alarmist. Truth be told I am pragmatic. And what I read and research about this nasty virus tells me this is no time to let our guard down. Get vaccinated as soon as you are eligible. In group settings or mingling amongst vaccination status unknowns wear a mask. Practice sensible hygiene. Don’t believe SARS-CoV-2/VOC’s is just an old person disease.

Meanwhile in Brazil…

By the way we have just one P.1 confirmed case in Oklahoma. Let’s together do what’s necessary to keep this number as low as possible.

Just Another SARS-CoV-2 Vaccine Chart – Updated 03.25.21

Vaccine table produced by Monica Gandhi MD MPH. Downloaded from Twitter 03.27.21

Monica Gandhi MD, MPH is Professor of Medicine and Associate Division Chief (Clinical Operations/ Education) of the Division of HIV, Infectious Diseases, and Global Medicine at UCSF/ San Francisco General Hospital. She also serves as the Director of the UCSF Center for AIDS Research (CFAR) and the Medical director of the HIV Clinic at SFGH (“Ward 86”). Dr. Gandhi completed her M.D. at Harvard Medical School and then came to UCSF in 1996 for residency training in Internal Medicine. After her residency, Dr. Gandhi completed a fellowship in Infectious Diseases and a postdoctoral fellowship at the Center for AIDS Prevention Studies, both at UCSF. She also obtained a Masters in Public Health from Berkeley in 2001 with a focus on Epidemiology and Biostatistics.

https://profiles.ucsf.edu/monica.gandhi

The Latest in COVID-19 News: Week Ending 03.20.21 – NEJM Journal Watch

Click on the link for the NEJM Journal Watch weekly update.  Another good week for SARS-CoV-2 articles. Sorry about not posting last week’s Journal Watch link of links. I forgot AND I was out of town which made me forget.

https://www.jwatch.org/fw117630/2021/03/20/latest-covid-19-news-week-ending-mar-20-2021

Meanwhile Sammy sings from what appears to be an empty closet.

SARS-CoV-2 Variants – (in mice)

Pre-print therefore not peer reviewed. No, I don’t hang out on Twitter all day long. Yes, the study is somewhat geeky. BUT here’s the money sentence:

This abrogation of the species barrier raises the possibility of wild rodent secondary reservoirs and provides new experimental models to study disease pathophysiology and countermeasures.

The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice — https://www.biorxiv.org/content/10.1101/2021.03.18.436013v1

Now I can’t stop thinking about “secondary reservoirs”.