Updated table on vaccines reducing transmission pic.twitter.com/LEBfxp1eZK
— Monica Gandhi MD, MPH (@MonicaGandhi9) May 1, 2021
Infectious Diseases
The Latest in COVID-19 News: Week Ending 04.24.21 – NEJM Journal Watch
Click on the link for the NEJM Journal Watch weekly update. Not a lot of links this week for SARS-CoV-2 articles but again I did not forget to post this.
https://www.jwatch.org/fw117733/2021/04/24/covid-19-news-week-ending-apr-24-2021
So in the spirit of big news that didn’t get mentioned in this week’s NEJM Journal Watch:
FDA, CDC Lift Suspension of Johnson & Johnson Vaccine
Cite this: FDA, CDC Lift Suspension of Johnson & Johnson Vaccine – Medscape – Apr 23, 2021 — https://www.medscape.com/viewarticle/949913
Meanwhile pray for India.
India has recorded nearly a million infections in three days, with 346,786 new cases overnight into Saturday.
India Covid surge: Hospitals send SOS as record deaths registered — https://www.bbc.com/news/world-asia-56870410
The Latest in COVID-19 News: Week Ending 04.17.21 – NEJM Journal Watch
Click on the link for the NEJM Journal Watch weekly update. A blood clot week for SARS-CoV-2 articles.
https://www.jwatch.org/fw117711/2021/04/17/covid-19-news-week-ending-apr-17-2021
A team of researchers in the United Kingdom conducted an in-depth investigation of 22 patients who developed serious blood clots combined with a drop in blood platelets after receiving a dose of the AstraZeneca vaccine, which is now called Vaxzevria. They also tested an additional patient who had clinical signs of a drop in blood platelets after vaccination. Nearly all the patients — 22 of 23 — tested positive for unusual antibodies to platelet factor 4, a signaling protein that helps the body coordinate blood clotting.
Citation: Researchers Detail More Cases of Rare Clots Tied to COVID Vaccines – Medscape – Apr 16, 2021 — https://www.medscape.com/viewarticle/949473?src=rss
My Only Comment on the J&J Covid Vaccine Blood Clot Risk
Dr. Karb was in the same residency class at Brown as Dr. Lee.
I have much respect for Brownies.
That’s it. My only comment on the J&J vaccine blood clot risk.
The Latest in COVID-19 News: Week Ending 04.10.21 – NEJM Journal Watch
Click on the link for the NEJM Journal Watch weekly update. Another good week for SARS-CoV-2 articles. For the second week in a row I did not forget to post this link.
https://www.jwatch.org/fw117693/2021/04/10/latest-covid-19-news-week-ending-apr-10
Meanwhile in B.C. Canada…

COVID-19 Vaccinations by Race/Ethnicity
While the data provide useful insights, they also remain subject to gaps, limitations, and inconsistencies that limit the ability to get a complete picture of who is and who is not getting vaccinated. For example, data gaps and separate reporting of data for vaccinations administered through the Indian Health Service limit the ability to analyze vaccinations among American Indian and Alaska Native people and Native Hawaiian and Other Pacific Islander. Moreover, some states have high shares of vaccinations that are missing race/ethnicity or that are classified as “other,” limiting the ability to interpret the data. For example, in Alaska, over 30% of vaccinations were among people classified as “other” race, and race was unknown for over 30% of vaccinations in Virginia. Four states were not reporting vaccination data by race/ethnicity, including Georgia which halted reporting its data in March. Comprehensive standardized data across states will be vital to monitor and ensure equitable access to and take up of the vaccine.
Latest Data on COVID-19 Vaccinations Race/Ethnicity — https://www.kff.org/coronavirus-covid-19/issue-brief/latest-data-on-covid-19-vaccinations-race-ethnicity/
Meanwhile in Oklahoma…
T cells recognize recent SARS-CoV-2 variants

In their study of recovered COVID-19 patients, the researchers determined that SARS-CoV-2-specific CD8+ T-cell responses remained largely intact and could recognize virtually all mutations in the variants studied. While larger studies are needed, the researchers note that their findings suggest that the T cell response in convalescent individuals, and most likely in vaccinees, are largely not affected by the mutations found in these three variants, and should offer protection against emerging variants.
T cells recognize recent SARS-CoV-2 variants — https://www.nih.gov/news-events/news-releases/t-cells-recognize-recent-sars-cov-2-variants
The Latest in COVID-19 News: Week Ending 04.03.21 – NEJM Journal Watch
Click on the link for the NEJM Journal Watch weekly update. Another very good week for SARS-CoV-2 articles. I forgot about this update until Sunday after numerous cups of coffee.
https://www.jwatch.org/fw117673/2021/04/03/latest-covid-19-news-week-ending-apr-3
Happy Easter from Brazil…
What is driving the second wave in India? — Science Chronicle
Understanding the infectiousness of the double mutant variant becomes all the more important as noncompliance to COVID-19 appropriate behaviour is uniformly poor across India. Yet, the surge in cases is seen only in 19 States, and mainly in about a dozen States. In the absence of timely results of such studies, which will help policy […]
What is driving the second wave in India? — Science Chronicle
Just the use of the phrase “double mutant variant” sends chills up my spinal cord.
Covid-19 and Young Adults – You Are Not Invincible (a gentle reminder)
Whistler recorded 1,120 COVID-19 cases from the beginning of January to March 28, with 218 of them last week alone, driven by the P.1 variant most commonly associated with Brazil. The majority of cases – 83.2 per cent – are in people aged 20 to 39.
Variant that forced B.C. ski resort shut is rapidly spreading, sending more young people to hospital — https://www.theglobeandmail.com/canada/article-covid-19-variant-spreading-rapidly-in-bc/
Young adults age 18 to 34 years hospitalized with COVID-19 experienced substantial rates of adverse outcomes: 21% required intensive care, 10% required mechanical ventilation, and 2.7% died. This in-hospital mortality rate is lower than that reported for older adults with COVID-19, but approximately double that of young adults with acute myocardial infarction.4 Morbid obesity, hypertension, and diabetes were common and associated with greater risks of adverse events. Young adults with more than 1 of these conditions faced risks comparable with those observed in middle-aged adults without them. More than half of these patients requiring hospitalization were Black or Hispanic, consistent with prior findings of disproportionate illness severity in these demographic groups.5,6
Clinical Outcomes in Young US Adults Hospitalized With COVID-19 — https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2770542
Please get vaccinated as soon as you’re eligible. This is a gentle reminder before I start getting a bit harsher with my messaging.
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