Yogurt and CSBMs (Complete Spontaneous Bowel Movements)

In a randomized controlled trial, the probiotic Bifidobacterium animalis subsp. lactis—used in many probiotic products, including Dannon’s Activia yogurts—did nothing to improve bowel health in people with constipation, according to data from a randomized triple-blind placebo-controlled clinical trial published Wednesday in JAMA Network Open. Popular gut probiotic completely craps out in randomized controlled trialhttps://arstechnica.com/health/2024/10/popular-gut-probiotic-completely-craps-out-in-randomized-controlled-trial/

Here’s a lesson in the need to read the original study. I found this statement from the researchers:

The 2 study groups were very similar with respect to baseline characteristics. The participants had a low dietary fiber intake (9 g/d), which is in line with observations by others (11.7 g/d) and well below recommended levels (25.0 g/d).14 This may be a contributing factor to the bowel movement problems experienced by the participants. Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipationhttps://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824333

IMO the low dietary fiber intake in this shitting study leads me to think the entire study results were…crappy.

BTW yesterday I had two CSBMs. That’s what I get for eating a bowl of black eye peas http://garyskitchen.net/2022/01/16/vegetarian-badass-black-eyed-peas-2022/ and a baked sweet potato in the same day.

SIDD, SIRD, MOD, AND MARD – DM2 Subgroups

Type 2 diabetes (T2D) was recently reclassified into severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD), which have different risk of complications. We explored whether DNA methylation differs between these subgroups and whether subgroup-unique methylation risk scores (MRSs) predict diabetic complications.

Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns That Associate With Future Diabetic Complications — https://doi.org/10.2337/dc21-2489

More acronyms!