Lower microstructural integrity of brain white matter is related to higher mortality

Conclusions: Our findings suggest that impairments in cerebral white matter, even at early stages, are not limited to adverse brain outcomes and they are related to mortality, especially from cardiovascular causes.

Source: Lower microstructural integrity of brain white matter is related to higher mortality

Alternative Dementia Screening Tests | Physician’s Weekly

Alternative Dementia Screening Tests | News Brief


Chinese investigators suggest that there are multiples alternatives to the Mini-Mental State Examination that have comparable diagnostic capabilities for detecting dementia. The Mini-Cog test and the Addenbrooke’s Cognitive Examination-Revised were deemed the most effective alternative screening tests for dementia. The Montreal Cognitive Assessment was determined to be the optimal alternative for detecting mild cognitive impairment.

Source: JAMA Internal Medicine, September 2015.

Source: Alternative Dementia Screening Tests | Physician’s Weekly

Compulsive Decluttering: The Opposite of Hoarding – The Atlantic

Getting rid of belongings is generally seen as positive, even healthy—but when the need becomes compulsive, it can be a sign of a life-consuming disorder.

Source: Compulsive Decluttering: The Opposite of Hoarding – The Atlantic

OCD variants – Compulsive Decluttering or Obsessive Compulsive Spartanism.  Puts the Tiny House movement in a different light, no?

Epilepsy Increases Mortality Risk in Pregnant Women | Medpage Today

Sarah C. MacDonald, BSc, of the Harvard T. H. Chan School of Public Health, and colleagues, found that after adjusting for several confounders, women with epilepsy had a more than 10-fold increased risk of death during delivery hospitalization (adjusted odds ratio 11.46, 95% CI 8.64-15.19) compared with women without epilepsy (80 deaths per 100,000 pregnancies versus six deaths in 100,000 pregnancies).

via Epilepsy Increases Mortality Risk in Pregnant Women | Medpage Today.

BBC News – Sleep ‘cleans’ the brain of toxins

Their findings build on last year’s discovery of the brain\’s own network of plumbing pipes – known as the glymphatic system – which carry waste material out of the brain.

via BBC News – Sleep ‘cleans’ the brain of toxins.

I sleep late a lot on weekends.  The Boss complains, thinks I sleep too much.  Now I can say my glymphatic system is working overtime.  And your brain needs a good cleaning…

More Chocolate Please – Cocoa May Boost Brain Function in Seniors

Older people who had impaired neurovascular coupling at baseline and drank two cups of cocoa a day for a month had significant improvement in cognitive function and blood flow in the brain.

via Cocoa May Boost Brain Function in Seniors.

Now I don’t feel so bad about eating a bunch of dark chocolate covered walnuts on Saturday evening.

Afib Linked to Silent Stroke

MRI indicated silent cerebral ischemia lesions in 89% patients with paroxysmal Afib and 92% with persistent Afib compared with 46% of controls, which wasn’t significantly different between the two types of Afib but was for both versus controls (P<0.01).

The number of these lesions averaged 41 in persistent Afib, 33 in paroxysmal Afib, and 12 in controls, which was significantly different for all three groups.

The high prevalence of these lesions in the control group compared with what has been reported in the general population may have reflected the moderate to high cardiovascular risk among these patients referred for cardiovascular prevention or treatment, the researchers suggested.

The lesions can have either ischemic and embolic origins, but the peculiar “spotted” distribution of “small sharply demarcated lesions, often in cluster, with bilateral distribution, prevalently in the frontal lobe” seen in 50% and 67% of the paroxysmal and persistent Afib patients, respectively, strongly supported an embolic mechanism, they noted.

via Afib Linked to Silent Stroke.

If these findings are replicated in future studies, the question for underwriters is should any Afib risk be Standard mortality?

1 in 3 Americans has Dementia at Time of Death

One in three older adults has Alzheimer’s disease or another type of dementia at the time of death. As the nation’s population ages, the number of people with the progressive neurological disorder could triple in the next 40 years, said a study published online Feb. 6 in Neurology.

via 1 in 3 Americans has dementia at time of death – amednews.com.