Pharma

Snorting bupropion – The Poison Review

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Snorting bupropion | The Poison Review.

The abuse of bupropion by pulverizing and snorting the medication has been described at least as far back as 2002. Bupropion inhibits re-uptake of dopamine and norepinephrine, but apparently has little or no effect on serotonin. It is abused for its psychotropic effects that resemble those of amphetamine and cocaine..

A hallmark of overdose with sustained-release or extended-release bupropion formulations is delayed onset of seizures — sometimes more than 8 hours after ingestion. When these preparations are crushed and insufflated, absorption is rapid and manifestations would be expected to come on more quickly.

– See more at: http://www.thepoisonreview.com/2014/11/12/snorting-bupropion/#sthash.35NLtujG.dpuf

Neurotoxicity with Antimicrobials in the Elderly: A Review – Clinical Therapeutics

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Yikes!

Neurotoxicity with Antimicrobials in the Elderly: A Review – Clinical Therapeutics.

Findings

Various antimicrobial classes are implicated with neurotoxicity. The classes with the most reported cases include fluoroquinolones, macrolides, sulfonamides, nitrofurans, and β-lactams. A higher risk of developing various symptoms of neurotoxicity was found in the elderly with use of piperacillin and tazobactam, cephalosporins, carbapenems, aminoglycosides, trimethoprim and sulfamethoxazole, nitrofurantoin, linezolid, and possibly the fluoroquinolones. Potential mechanisms of neurotoxicity differ between the agents. The etiology of neurotoxicity with some agents is not fully elucidated. Incidence may increase with reported risk factors, renal dysfunction, or drug interactions.

JAMA – Treating Prescription Opioid Dependence

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JAMA Network | JAMA | Treating Prescription Opioid Dependence.

Conclusions and Relevance This study represents a rigorous experimental evaluation of outpatient buprenorphine stabilization, brief taper, and naltrexone maintenance for treatment of PO dependence. Results suggest that a meaningful subset of PO-dependent outpatients may respond positively to a 4-week

 

Naltrexone maintenance?  I bet they’ll lost weight too.

http://underwritingsolutionsllc.com/2014/09/14/fda-approves-bupropionnaltrexone-contrave-for-obesity/

Deaths From Narcotic Painkillers Quadrupled in Past Decade: CDC – WebMD

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Deaths From Narcotic Painkillers Quadrupled in Past Decade: CDC – WebMD.

Deaths from overdoses of drugs such as hydrocodone (Vicodin), morphine and oxycodone (Oxycontin) climbed from 1.4 per 100,000 people to 5.4 per 100,000, according to the U.S. Centers for Disease Control and Prevention.

That means about 3,000 people died in 1999 from unintentional overdoses. By 2011, that number was up to nearly 12,000 deaths, the report said.