Causality was called very likely due to flavocoxid in three patients and possibly due to the agent in one patient, as that case was complicated by exposure to several other agents that may have caused the injury, including pregabalin (Lyrica), duloxetine (Cymbalta), and tizanidine (Zanaflex).
Pharma
Teva’s Adderall 30 mg Tabs – Counterfeit Product – Contains Wrong Active Ingredients
The counterfeit Adderall tablets are round, white and do not have any type of markings, such as letters or numbers. Authentic Adderall 30 mg tablets produced by Teva are round, orange/peach, and scored tablets with “dp” embossed on one side and “30” on the other side of the tablet.
Adderall contains four active ingredients – dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate. Instead of these active ingredients, the counterfeit product contained tramadol and acetaminophen, which are ingredients in medicines used to treat acute pain.
If you or your child is bouncing off the walls AND you bought Adderall off the Internet, check to see if your tablets are white and have no markings.
DailyMed – Current Medication Information
Here is another medication information resource I like a lot. It is from the NLM and NIH. I’m also adding a link on the sidebar.
Finasteride Sexual Side Effects Prompt FDA Warning, Label Changes
Proscar is indicated for treatment of symptoms in men with benign prostatic hyperplasia (BPH) and also is approved to reduce urinary retention risk or the need for surgery related to BPH. Propecia is approved for use only in men as a treatment for male pattern baldness.
Among specific changes the FDA is calling for are:
- a revision to the Propecia label to add libido disorders, ejaculation disorders and orgasm disorders that continued after the drug was discontinued;
- a revision to the Proscar label to include decreased libido that continued after the drug was discontinued; and
- revisions to both drugs’ labels that describe reports of male infertility and/or poor semen quality that normalized or, at least, improved after discontinuing the respective drug.
According to the agency, the changes were based on its review of hundreds of case reports of sexual dysfunction that persisted after patients ceased using the drugs. It should be noted that in 2011, the FDA called for both drugs’ labels to be revised to include erectile dysfunction as a side effect that continued after discontinuation of the drug.
Got Long QT? No Citalopram For You
- Patients with congenital long QT syndrome are at particular risk of torsades de pointes, ventricular tachycardia and sudden death when given drugs that prolong the QT interval. Nevertheless, the labeling recommendation for patients with congenital long QT syndrome has been changed from “contraindicated” to “not recommended,” because it is recognized that there may be some patients with this condition who could benefit from a low dose of citalopram and who lack viable alternatives. Similarly, the drug is not recommended for those who have bradycardia, hypokalemia or hypomagnesemia, recent acute myocardial infarction, or uncompensated heart failure.
- Although citalopram use should be avoided, if possible, in patients with certain conditions because of the risk of QT prolongation, ECG monitoring and electrolyte monitoring should be performed if citalopram must be used in these patients.
- The maximum recommended dose of citalopram is 20 mg per day for patients with hepatic impairment, adults older than 60, patients who are CYP2C19 poor metabolizers, and those who are taking cimetidine or another CYP2C19 inhibitor concurrently.
- Citalopram should be discontinued in patients who are found to have persistent QT measurements (corrected for heart rate) greater than 500 milliseconds.
Minor Trauma Led to Death in Pradaxa Patient
Dabigatran etexilate is an oral anticoagulant that acts as a direct, competitive thrombin inhibitor. It does not require routine monitoring and has been approved by the FDA for the prevention of stroke and systemic embolism in patients with atrial fibrillation. Note, however, that no effective reversal agent for dabigatran in the event of catastrophic hemorrhage has been identified.
On the article’s webpage you’ll find a link to download a PDF copy of the source article.
Antidepressant Use Soaring – MayoClinic.com
One in 10 people over age 12 in the United States is taking an antidepressant, according to the National Health and Nutrition Examination Survey, which is conducted by the Center for Disease Control. Women between the ages of 40 and 59 are the most likely group to take antidepressants. In this age range, 23 percent of U.S. women are taking one.
via Antidepressant use soaring among Americans 12 and over – MayoClinic.com.
Effect of Two Intensive Statin Regimens on Progression of Coronary Disease — NEJM
Acetaminophen OD More Deadly if Taken in Stages
Those who ingested more than 4,000 mg of acetaminophen in a single day spread out over more than one time point had a significantly higher mortality rate compared with those who overdosed at a single time point (37.3% versus 27.8%, P=0.025), according to Kenneth Simpson, MD, of the University of Edinburgh in Scotland, and colleagues.
The cohort analysis included 663 patients admitted with acetaminophen-induced severe liver injury from November 1992 through October 2008. About one-quarter (24.3%) overdosed in a staggered fashion, defined as taking at least two excessive doses separated by more than eight hours and adding up to more than 4,000 milligrams in one day. The rest of the patients ingested that much at a single time point.
Most of the patients who had a staggered overdose (58.2%) said that pain relief was the reason they repeatedly took an excessive dose. Another 34.3% said it was a suicide attempt.
Learn more at Acetaminophen Toxicity.
Personally I rarely take the stuff. It’s pure poison for the liver.
lifeunderwriter.net 
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