Sleep Apnea Linked to Cancer

Sleep Apnea Linked to Cancer.

Moderate-to-severe OSA was associated with a 2.5-fold higher likelihood of incident cancer (95% CI 1.2-5.0) after adjustment for obesity and a full range of other factors, Nathaniel Marshall, PhD, of the University of Sydney Nursing School in Australia, and colleagues found.

Cancer mortality was 3.4 times more common (95% CI 1.1-10.2) in those with sleep apnea than with no sleep apnea during 20 years of follow-up, they reported in the April 15 issue of theJournal of Clinical Sleep Medicine.

Sleep Apnea Severity Tied to Cardiac Marker

  • Obstructive sleep apnea is associated with cardiovascular morbidity and mortality, particularly heart failure, a study found.
  • The severity of obstructive sleep apnea was significantly associated with higher levels of high-sensitivity troponin, suggesting that subclinical myocardial injury may play a role in the association with risk of heart failure.

via Sleep Apnea Severity Tied to Cardiac Marker.

Reduced Total Lung Capacity and Mortality

Background: Pulmonary restriction is associated with increased mortality in adults, especially those who are elderly. Previous studies, however, have used the FVC as a surrogate for the total lung capacity (TLC). We evaluated the association between a reduced TLC, mortality, and health-care resources use and compared this association with a reduced FVC.

Conclusions: Reduced TLC is strongly associated with mortality in adults who are elderly. Reduction of the FVC is a weaker risk factor for mortality.

via Association of Reduced Total Lung Capacity With Mortality and Use of Health Services.

Emphysema on CT Significantly Correlated With Mortality

Click through for the abstract.  There is a link on the page for a PDF version.

CT Scan Findings of Emphysema Predict Mortality in COPD — CHEST

Results: Of the 251 patients, 79 died, with 40 classified as respiratory deaths not involving lung cancer. Univariate Cox analysis revealed that emphysematous change as assessed by CT scan, lung function, age, or BMI were significantly correlated with mortality. Multivariate analysis revealed that emphysematous change as assessed by CT scan had the best association with mortality.

Conclusions: Emphysematous change as assessed by CT scan predicts respiratory mortality in outpatients with various stages of COPD.