Safety Information > February 2014.
Get to Know an Enzyme: CYP3A4.
I routinely check the FDA drug safety information for personal reasons. One thing led to another, thus the reason for the CYP3A4 link. If you like puzzles, try to figure out why I’m reading up on CYP3A4. My son the molecular biochemist soon to be MD would have no problem figuring this out.
CONCLUSIONS: In PDR+ patients, cerebral microbleed prevalence was higher and seems part of generalized microangiopathy that may affect the skin and the brain.
CONCLUSIONS: AAs and Hispanics with diabetes have a higher prevalence of early CKD compared with whites, which is significantly associated with UAE and/or CRP.
Conclusion: Hepatic steatosis is associated with a greater intake of fat and fried foods, whereas visceral obesity is associated with increased consumption of sugar and reduced consumption of fiber in overweight and obese adolescents at risk of type 2 diabetes. This study was registered at clinicaltrials.gov as NCT00755547.
The association between all-cause mortality and BMI created a U-shaped curve with a broad base (P-nonlinearity <0.001). The “nadir of the curve for BMI and mortality was between 24.0 and 30.9, with the lowest risk being between 27.0 and 27.9 (HR 0.90, 95% CI 0.88-0.92),” wrote Caryl A. Nowson, PhD, of Deakin University in Melbourne, Australia, and her co-authors, in the American Journal of Clinical Nutrition.
They said that mortality risk did not increase with excess weight in this population until BMI was ≥33 (HR 1.08 for BMI of 33.0-33.9, 95% CI 1.00-1.15).
Risk of mortality was highest at a BMI lower than 23, the authors said. Using a BMI of 23.0 to 23.9 as the reference, there was a 12% greater risk of mortality for those with a BMI in the range of 21.0-21.9 (HR 1.12, 95% CI 1.10-1.13) and a 19% greater risk for those with a BMI in the range of 20.0-20.9 (HR 1.19, 95% CI 1.17-1.22), the authors said.
via Higher BMI May Be Better for Older Adults.
BMI and all-cause mortality in older adults: a meta-analysis.
Clinically Relevant Herb-Drug Interactions—Lecture by Dr. Bill Gurley | NCCAM.
Budget an hour for this lecture.
The study, which was published in the Journal of Adolescent Healthanalyzed medical claims and pharmacy data from 8,373, 13- to 17-year-olds who visited a clinician for headache, which is a common ailment in adolescents.
Forty-six percent received one prescription for an opioid; 23% got two prescriptions and 29% got three or more prescriptions.
Results: In men, the HF F&V diet increased endothelium-dependent microvascular reactivity P = 0.017 with +2 portions/d at 6 wk and reduced C-reactive protein P = 0.001, E-selectin P = 0.0005, and vascular cell adhesion molecule P = 0.0468 with +4 portions/d at 12 wk. HF F&Vs increased plasma NO P = 0.0243 with +4 portions/d at 12 wk in the group as a whole. An increase in F&Vs, regardless of flavonoid content in the groups as a whole, mitigated increases in vascular stiffness measured by PWA P = 0.0065 and reductions in NO P = 0.0299 in the control group.
Mom was right.
Primary care doctors wrote about 53 million benzodiazepine prescriptions in 2013, roughly four times the number written by psychiatrists, a group that penned 13 million benzo scripts.
Nurse practitioners and physician assistants were close behind with 11 million prescriptions for the drugs, according to data obtained by MedPage Today and the Milwaukee Journal Sentinel.
In 2013, non-doctors wrote 30 million opioid prescriptions, compared with 92 million written by primary care doctors that year, according to data provided by IMS Health, a drug market research firm.
In 2010, the most recent year for which data were available, 30% of the 16,651 people who died of an opioid overdose also had taken a benzodiazepine, according to the U.S. Centers for Disease Control and Prevention.
via Killing Pain: Script by Script.
ICD-10 Follies: Struck by Golf Ball.
W21.04XA – initial encounter
lifeunderwriter.net 
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