Cannabis and Impaired Brain Development

The adolescent brain is particularly vulnerable to cannabis, especially today’s higher-potency products, which put teens at risk for impaired brain development; mental health issues, including psychosis; and cannabis use disorder (CUD).  That was the message delivered by Yasmin Hurd, PhD, director of the Addiction Institute at Mount Sinai in New York, during a May 6 press briefing at the American Psychiatric Association (APA) 2024 annual meeting

“We’re actually in historic times in that we now have highly concentrated, highly potent cannabis products that are administered in various routes,” Hurd told reporters. Tetrahydrocannabinol (THC) concentrations in cannabis products have increased over the years, from around 2%-4% to 15%-24% now, Hurd noted. High-Potency Cannabis Tied to Impaired Brain Development, Psychosis, CUD – Medscape – May 13, 2024. https://www.medscape.com/viewarticle/high-potency-cannabis-tied-impaired-brain-development-2024a1000935

Earlier posts on this topic:

Marijuana is Too Strong (THC turbocharged)

Cannabis Use and Psychosis Risk

Cannabis Use and Psychosis Risk (Aussie Version)

Reefer Madness

Diet and Your Immune System

Whereas nutrition scientists have conventionally studied the long-term impacts of loosely defined Mediterranean or Western diets, for example, today they have access to tools that allow them to zoom in on the short-term effects — both helpful and harmful — of narrower food groups and specific dietary components, and to probe the molecular mechanisms underpinning the effects of foods on immunity. Your diet can change your immune system — here’s how https://www.nature.com/articles/d41586-024-03334-0

Nice article summarizing the latest research in diet and the immune system.

Alcohol and Nocturnal Leg Cramps (NLC)

I just discovered another reason to Drink Less Alcohol When You Get To My Age.

We identified an association between alcohol consumption and nocturnal leg cramps among patients aged 60 years and older attending general practices. These findings have implications for the prevention of cramps. Association Between Alcohol Consumption and Nocturnal Leg Cramps in Patients Over 60 Years Old: A Case-Control Studyhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037509

Add this to the list of things that happen when you get older.

Food for Thought (and memories)

Mealtime can provide opportunities to connect with someone experiencing memory loss and tap into deeply rooted memories. “If you’re going to make your father’s favorite meal, think about how you can delve into it as an experience,” Aguirre says. Dr. Kramer notes that several senses associated with cooking and eating dishes, including smell and taste, are closely related to memory. Both the olfactory bulb, the main receiving center for smell, and the insular cortex and frontal operculum (also called the gustatory cortex), responsible for perception of taste, are closely connected to the amygdala, an area involved in emotional learning. The olfactory nerve, which conveys the sense of smell to the brain, is also close to the hippocampus, one of the most important brain structures for memory. And the combined effect of smell and taste—what neuroscientists who study this field call “flavor”—can be especially powerful at conjuring long-held memories charged with emotion, says Joel Salinas, MD, MBA, FAAN, assistant professor of neurology at NYU Langone Health and chief medical officer at Isaac Health, a clinic in New York City for brain health and memory problems.Favorite Meals May Trigger Memories in People with Dementiahttps://www.brainandlife.org/articles/food-may-trigger-memories-in-people-with-dementia

An Extended Period of Wandering

Now, I’m ‘no one,’ a retired, forgotten old man who dithers away the days.

”Depression can ensue, fueling excessive alcohol use, accidents, or, in the most extreme cases, suicide. Of all age groups in the United States, men over age 75 have the highest suicide rate, by far. Older Men’s Connections Often Wither When They’re on Their Own https://kffhealthnews.org/news/article/older-men-connections-isolation-loneliness-navigating-aging/

At the minimum I have a plan. Sell the house, buy a van and do an upscale conversion so I can sleep in it. Travel. Spend time in Oklahoma and Colorado.

Drink more Knob Creek (not when driving).

OOPS. Didn’t wait until the unthinkable.

Got Back Pain? Take a Walk

With all due respect to copyright law here’s the link to the Nat Geo article How walking can prevent lower back painhttps://www.nationalgeographic.com/science/article/walking-lower-back-pain-prevention-treatment

And here’s the link to The Lancet study Effectiveness and cost-effectiveness of an individualised, progressive walking and education intervention for the prevention of low back pain recurrence in Australia (WalkBack): a randomised controlled trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00755-4/fulltext

I’ve been on and off a heating pad for a week. I finally felt good enough to back to the Y and do some resistance training which included back stretches on one of those medieval looking torture devices. I went for a short walk today and my back feels better.

Keep moving.

Yogurt and CSBMs (Complete Spontaneous Bowel Movements)

In a randomized controlled trial, the probiotic Bifidobacterium animalis subsp. lactis—used in many probiotic products, including Dannon’s Activia yogurts—did nothing to improve bowel health in people with constipation, according to data from a randomized triple-blind placebo-controlled clinical trial published Wednesday in JAMA Network Open. Popular gut probiotic completely craps out in randomized controlled trialhttps://arstechnica.com/health/2024/10/popular-gut-probiotic-completely-craps-out-in-randomized-controlled-trial/

Here’s a lesson in the need to read the original study. I found this statement from the researchers:

The 2 study groups were very similar with respect to baseline characteristics. The participants had a low dietary fiber intake (9 g/d), which is in line with observations by others (11.7 g/d) and well below recommended levels (25.0 g/d).14 This may be a contributing factor to the bowel movement problems experienced by the participants. Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipationhttps://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824333

IMO the low dietary fiber intake in this shitting study leads me to think the entire study results were…crappy.

BTW yesterday I had two CSBMs. That’s what I get for eating a bowl of black eye peas http://garyskitchen.net/2022/01/16/vegetarian-badass-black-eyed-peas-2022/ and a baked sweet potato in the same day.

Researchers Have Mapped all 139,255 Neurons in the Brain of an adult fruit fly

An adult fruit fly’s brain is much more complex, however—and most importantly, the small insects share 60 percent of human DNA, as well 75 percent of the genes that cause genetic diseases, per a statement. As such, understanding the fly’s brain in such detail could hold implications for connections in human brains—and the neural pathways that lead to certain behaviors. Fruit flies, like humans, can get drunk, sing and be kept awake with coffee, suggesting similarities in our brains. https://www.smithsonianmag.com/smart-news/scientists-unveil-the-first-ever-complete-map-of-an-adult-fruit-flys-brain-captured-in-stunning-detail-180985191/

An actuary, an underwriter and a fruit fly walk into a bar…