Cardiovascular disease was the leading cause of death among the over 16,000 patients with type 2 diabetes (T2DM) who were enrolled in the SAVOR-TIMI 53 trial.
Two-thirds (66.3%) of all 798 deaths after a median 2.1 years of follow-up were caused by one of five cardiovascular (CV) conditions, with sudden cardiac death accounting for the largest share (30.1%) of the total, Ilaria Cavallari, MD, PhD, and associates said in the Journal of the American College of Cardiology.
It was a pair of laboratory measurements, however, that had the largest subdistribution hazard ratios. “Interestingly, the magnitude of associations of abnormal N-terminal pro–B-type natriuretic peptide [sHR, 2.82] and high-sensitivity troponin T [sHR, 2.46] measured in a stable population were greater than clinical variables in the prediction of all causes of death,” Cavallari and associates said.
CVD Remains Leading Cause of Death in Type 2 Diabetes – Medscape – Apr 06, 2021 — https://www.medscape.com/viewarticle/948849?src=rss
Dumb and Dumber – Noncompliance with Colonoscopy Post Positive FIT
Results Some 88 013 patients who were FIT positive complied with colonoscopy (males: 56.1%; aged 50–59 years: 49.1%) while 23 410 did not (males: 54.6%; aged 50–59 years: 44.9%).
The 10-year cumulative incidence of CRC was 44.7 per 1000 (95% CI, 43.1 to 46.3) among colonoscopy compliers and 54.3 per 1000 (95% CI, 49.9 to 58.7) in non-compliers, while the cumulative mortality for CRC was 6.8 per 1000 (95% CI, 5.9 to 7.6) and 16.0 per 1000 (95% CI, 13.1 to 18.9), respectively. The risk of dying of CRC among non-compliers was 103% higher than among compliers (adjusted HR, 2.03; 95% CI, 1.68 to 2.44).
Conclusion The excess risk of CRC death among those not completing colonoscopy after a positive faecal occult blood test should prompt screening programmes to adopt effective interventions to increase compliance in this high-risk population.
Non-compliance with colonoscopy after a positive faecal immunochemical test doubles the risk of dying from colorectal cancer — https://gut.bmj.com/content/early/2021/03/30/gutjnl-2020-322192?rss=1
Help me understand human behavior. You get a positive FOBT or Cologuard test and your doctor says you need a colonoscopy but you decide not to follow up and follow through with the scope.
SMH.
T cells recognize recent SARS-CoV-2 variants
In their study of recovered COVID-19 patients, the researchers determined that SARS-CoV-2-specific CD8+ T-cell responses remained largely intact and could recognize virtually all mutations in the variants studied. While larger studies are needed, the researchers note that their findings suggest that the T cell response in convalescent individuals, and most likely in vaccinees, are largely not affected by the mutations found in these three variants, and should offer protection against emerging variants.
T cells recognize recent SARS-CoV-2 variants — https://www.nih.gov/news-events/news-releases/t-cells-recognize-recent-sars-cov-2-variants
The Latest in COVID-19 News: Week Ending 04.03.21 – NEJM Journal Watch
Click on the link for the NEJM Journal Watch weekly update. Another very good week for SARS-CoV-2 articles. I forgot about this update until Sunday after numerous cups of coffee.
https://www.jwatch.org/fw117673/2021/04/03/latest-covid-19-news-week-ending-apr-3
Happy Easter from Brazil…
What is driving the second wave in India? — Science Chronicle
Understanding the infectiousness of the double mutant variant becomes all the more important as noncompliance to COVID-19 appropriate behaviour is uniformly poor across India. Yet, the surge in cases is seen only in 19 States, and mainly in about a dozen States. In the absence of timely results of such studies, which will help policy […]
What is driving the second wave in India? — Science Chronicle
Just the use of the phrase “double mutant variant” sends chills up my spinal cord.
Covid-19 and Young Adults – You Are Not Invincible (a gentle reminder)
Whistler recorded 1,120 COVID-19 cases from the beginning of January to March 28, with 218 of them last week alone, driven by the P.1 variant most commonly associated with Brazil. The majority of cases – 83.2 per cent – are in people aged 20 to 39.
Variant that forced B.C. ski resort shut is rapidly spreading, sending more young people to hospital — https://www.theglobeandmail.com/canada/article-covid-19-variant-spreading-rapidly-in-bc/
Young adults age 18 to 34 years hospitalized with COVID-19 experienced substantial rates of adverse outcomes: 21% required intensive care, 10% required mechanical ventilation, and 2.7% died. This in-hospital mortality rate is lower than that reported for older adults with COVID-19, but approximately double that of young adults with acute myocardial infarction.4 Morbid obesity, hypertension, and diabetes were common and associated with greater risks of adverse events. Young adults with more than 1 of these conditions faced risks comparable with those observed in middle-aged adults without them. More than half of these patients requiring hospitalization were Black or Hispanic, consistent with prior findings of disproportionate illness severity in these demographic groups.5,6
Clinical Outcomes in Young US Adults Hospitalized With COVID-19 — https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2770542
Please get vaccinated as soon as you’re eligible. This is a gentle reminder before I start getting a bit harsher with my messaging.
Covid-19 and Young Adults – You Are Not Invincible
Nice map from WAPO. Dr. Gandhi’s bird app post caught my eye. But for all you youngsters reading this it ain’t just Michigan.
Young adults age 18 to 34 years hospitalized with COVID-19 experienced substantial rates of adverse outcomes: 21% required intensive care, 10% required mechanical ventilation, and 2.7% died. This in-hospital mortality rate is lower than that reported for older adults with COVID-19, but approximately double that of young adults with acute myocardial infarction.4 Morbid obesity, hypertension, and diabetes were common and associated with greater risks of adverse events. Young adults with more than 1 of these conditions faced risks comparable with those observed in middle-aged adults without them. More than half of these patients requiring hospitalization were Black or Hispanic, consistent with prior findings of disproportionate illness severity in these demographic groups.5,6
Clinical Outcomes in Young US Adults Hospitalized With COVID-19 — https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2770542
No politics. No religion. No conspiracies. No bullshit. Please get vaccinated as soon as you’re eligible.
COVID-19 Diary – Day 381
Weekly New Infections Charts Every Monday we take a look at our week-to-week totals and chart how BC’s fight against COVID-19 is progressing. Because…
COVID-19 Diary – Day 381
SARS-CoV-2 Variants – P.1 Arrives in Oklahoma
The map on the CDC website is interactive and will show different variants by state.
I don’t consider myself to be an alarmist. Truth be told I am pragmatic. And what I read and research about this nasty virus tells me this is no time to let our guard down. Get vaccinated as soon as you are eligible. In group settings or mingling amongst vaccination status unknowns wear a mask. Practice sensible hygiene. Don’t believe SARS-CoV-2/VOC’s is just an old person disease.
Meanwhile in Brazil…
By the way we have just one P.1 confirmed case in Oklahoma. Let’s together do what’s necessary to keep this number as low as possible.
Just Another SARS-CoV-2 Vaccine Chart – Updated 03.25.21
Monica Gandhi MD, MPH is Professor of Medicine and Associate Division Chief (Clinical Operations/ Education) of the Division of HIV, Infectious Diseases, and Global Medicine at UCSF/ San Francisco General Hospital. She also serves as the Director of the UCSF Center for AIDS Research (CFAR) and the Medical director of the HIV Clinic at SFGH (“Ward 86”). Dr. Gandhi completed her M.D. at Harvard Medical School and then came to UCSF in 1996 for residency training in Internal Medicine. After her residency, Dr. Gandhi completed a fellowship in Infectious Diseases and a postdoctoral fellowship at the Center for AIDS Prevention Studies, both at UCSF. She also obtained a Masters in Public Health from Berkeley in 2001 with a focus on Epidemiology and Biostatistics.
https://profiles.ucsf.edu/monica.gandhi
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