Effect of Body Mass Index on Insulin Secretion or Sensitivity and Diabetes – American Journal of Preventive Medicine.
Although the association between obesity and diabetes is well known, the factors predisposing to diabetes in non-obese Asians are less clearly characterized.
Individuals with normal BMI may develop diabetes mainly through IIS, whereas individuals with high BMI may develop diabetes primarily through IR.
I am so screwed.
We observed a J-shaped association between BMI and mortality among all participants and among those who had ever smoked and a direct linear relationship among those who had never smoked. We found no evidence of lower mortality among patients with diabetes who were overweight or obese at diagnosis, as compared with their normal-weight counterparts, or of an obesity paradox.
via Body-Mass Index and Mortality among Adults with Incident Type 2 Diabetes — NEJM.
CONCLUSIONS: Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight loss interventions reduce mortality in all T2DM patients requires study.
via Association Between BMI Measured Within a Year After Diagnosis of Type 2 Diabetes and Mortality.
Could we have another U shaped mortality curve? Watch that BMI.
U-Shaped Link for BMI at Diagnosis With Mortality in Type 2 Diabetes | insureintell.com.
CONCLUSIONS Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight-loss interventions reduce mortality in all T2DM patients requires study.
via The Association Between BMI Measured Within a Year After Diagnosis of Type 2 Diabetes and Mortality.
HT – Hank George
While browsing the online Lancet website I came accross the following article. A J-shaped mortality curve should come as no surprise.
The Lancet, Early Online Publication, 18 March 2009
doi:10.1016/S0140-6736(09)60318-4Cite or Link Using DOI
Editors’ note: Around the world, increasing body-mass index (BMI) is a major public concern. Rightly so, according to this international collaborative analysis of almost 1 million people, followed from middle age in 57 prospective studies. A J-shaped mortality curve is observed, with optimal survival at a BMI of 22•5–25 kg/m2. Above this range, mortality from several causes—especially vascular diseases—was increased. Moderate obesity (BMI 30–35) was associated with 3 years’ loss of life. People with extreme obesity (BMI 40–50) lost 10 years of life, equivalent to the years lost by lifetime smoking.