Vitamin D and Calcium Reduce Incidence of Recurrent Vertigo (BPPV)

The multi-center study included 957 people in South Korea with benign paroxysmal positional vertigo who had undergone canalith repositioning maneuvers—head movements that shift displaced calcium carbonate crystals in the inner ear. The intervention group included patients who received 400 IU vitamin D and 500 mg calcium carbonate twice daily for 1 year when their baseline serum vitamin D level was below 20 ng/mL along with patients who had higher baseline levels and took no supplements. An observation group had no baseline testing or interventions.

The supplements significantly reduced the annual vertigo recurrence rate by 24%. There were 0.83 recurrences per 1 person-year in the intervention group compared with 1.10 in the observation group. Patients with greater vitamin D deficiencies at baseline derived the most benefit.

JAMA. 2020;324(16):1599. doi:10.1001/jama.2020.18695 —

BPPV = benign paroxysmal positional vertigo. The original study in Neurology and the JAMA summary both use the word “prevent” in their respective titles. I think reduce is a more apt description. Semantics aside a 24% reduction in recurrent BPPV episodes is significant.

And yet another example of nutritional deficiencies underlying another disease.

Is it really reasonable to obtain the recommended calcium intake on an unfortified and strictly vegan diet? — Nutritional revolution

It all started with an argument. Opening the refrigerator door. I say to my wife, scowling, “Why do we have so much cheese? We have talked about this.” Compared to milk, cheese is less nutrient dense and contains more calories. 1,211 more words

via Is it really reasonable to obtain the recommended calcium intake on an unfortified and strictly vegan diet? — Nutritional revolution

Vitamin D Plus Calcium May Cut Mortality Risk

Patients receiving both calcium and vitamin D had a 9% lower mortality rate through 3 years of treatment than those not receiving vitamin D (HR 0.91, 95% CI 0.84 to 0.98), according to Lars Rejnmark, MD, PhD, of Aarhus University in Aarhus, Denmark, and colleagues.

via Medical News: Vitamin D Plus Calcium May Cut Mortality Risk – in Primary Care, Diet & Nutrition from MedPage Today.

How about a non-prescription supplement and vitamin questionnaire?

Calcium Supplements and MI Risk

Medical News: Risk of MI May Go Up With Calcium Supplements – in Cardiovascular, Myocardial Infarction from MedPage Today

Calcium supplementation appears to increase the risk of myocardial infarction, a meta-analysis showed.

Among studies of patients with or at risk for osteoporosis, those who took calcium supplements were about 30% more likely to have an MI than those who did not, Ian Reid, MD, of the University of Auckland in New Zealand, and colleagues reported online in BMJ.

Among randomized controlled trials with patient-level data, the hazard ratio for MI with supplementation was 1.31 (95% CI 1.02 to 1.67). Among those with trial-level data, the relative risk was 1.27 (95% CI 1.01 to 1.59).

Abnormal Calcium = Increased Mortality in Kidney Disease

Note this is an observational study and causality should not be assumed.

Medical News: Abnormal Calcium Increases Mortality in Kidney Disease – in Nephrology, General Nephrology from MedPage Today

Abnormal levels of serum calcium are associated with increased mortality in patients with non-dialysis-dependent chronic kidney disease, an observational study found.

A one mg/dL elevation in baseline calcium levels was associated with a multivariable adjusted hazard ratio for mortality of 1.31 (95% CI 1.13 to 1.53, P<0.001), according to Csaba P. Kovesdy, MD, of the Salem, Va., Veterans Affairs Medical Center, and colleagues.

There also was a significant interaction between elevated baseline calcium level and the presence of cardiovascular disease, which raised the hazard ratio to 1.58 (95% CI 1.29 to 1.94, P<0.001), the researchers reported online in the Clinical Journal of the American Society of Nephrology.