CHD risk factors

Mediterranean Diet Cuts Risk of Diabetes

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Compared with a control diet and a Mediterranean diet supplemented with mixed nuts, the olive oil-supplemented Mediterranean diet was associated with a 40% lower likelihood for new-onset diabetes (HR 0.60, 95% CI 0.43-0.85) , according to Jordi Salas-Salvado, MD, PhD, of the Universitat Rovira i Virgili in Reus, Spain, and colleagues.

Dieters who consumed a nut-supplemented Mediterranean diet did not see such protective benefits (HR 0.82, 95% CI 0.61-1.10), they wrote online in the Annals of Internal Medicine.

via Mediterranean Diet Cuts Risk of Diabetes.

Read the article and then the readers’ comments.  The following are some excerpts:

The findings of this study identify inherent weaknesses in methodology. The low fat control group did not adhere to a low fat diet and the improbable risks of CVD were notably higher.

 

I wonder if the researchers would consider the benefits of asking their subjects to spread their food intake more evenly throughout the day rather than the the usual Spanish pattern of negligible breakfast, snack about 11, then large lunch mid-afternoon and a big, late evening meal. Also in my experience travelling in various parts of Spain, the diet includes plenty of pork.’Every bit of the pig but the eyes.’.

 

The olive oil group was probably using that in place of other vegetable oils for cooking and salad. Vegetable oils like soy and corn oil are high in pro-inflammatory omega-6, and are often partially hydrogenated (ie trans fats.) Avoidance of these in the olive group could have made a difference.

 

Be cautious in coming to conclusions based upon this study.  The sample size was small.  Perhaps too little attention was paid to what the participants did not consume.  We all know less red meat is better for health.  The Mediterranean style diet is clearly a healthy diet but I’m not quite ready to attribute all the wonderful benefits to the diet alone.

Think lifestyle.  Despite the increase in US style fast food restaurants in Spain, the overall dietary preference continues to be a Mediterranean diet.  So how much of the study’s effect come from fast food avoidance?

BTW, yesterday was a totally Mediterranean day for me.  Veggie pizza for lunch and a Greek salad with grilled chicken for dinner.

 

 

MI Admissions on Upswing in Younger Women

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Bucking the trend in other groups, younger women in that province experienced an increase in the hospitalization rate of 1.7% per year from 2000 through 2009 (P=0.04), according to Karin Humphries, MBA, DSc, of the University of British Columbia in Vancouver, and colleagues.

In addition, in that younger group, women had a greater risk of dying within 30 days of hospital discharge compared with men, a difference that persisted through the end of the study period (OR 1.61, 95% CI 1.25-2.08), the researchers reported online in the Journal of Women\’s Health.

via MI Admissions on Upswing in Younger Women.

Lexiscan (regadenoson) and Adenoscan (adenosine): Drug Safety Communication – Rare but Serious Risk of Heart Attack and Death

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BACKGROUND: Lexiscan and Adenoscan are FDA approved for use during cardiac nuclear stress tests in patients who cannot exercise adequately. Lexiscan and Adenoscan help identify coronary artery disease. They do this by dilating the arteries of the heart and increasing blood flow to help identify blocks or obstructions in the heart’s arteries. Lexiscan and Adenoscan cause blood to flow preferentially to the healthier, unblocked or unobstructed arteries, which can reduce blood flow in the obstructed artery. In some cases, this reduced blood flow can lead to a heart attack, which can be fatal. RECOMMENDATIONS: Screen all nuclear stress test candidates for their suitability to receive Lexiscan or Adenoscan. Avoid using these drugs in patients with signs or symptoms of unstable angina or cardiovascular instability, as these patients may be at greater risk for serious cardiovascular adverse reactions. Cardiac resuscitation equipment and trained staff should be available before administering Lexiscan or Adenoscan.

via Safety Alerts for Human Medical Products > Lexiscan regadenoson and Adenoscan adenosine: Drug Safety Communication – Rare but Serious Risk of Heart Attack and Death.

Blue Bunny to Lay Off 58 workers – The Des Moines Register | desmoinesregister.com

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The cut comes at a time when Iowa also is being buffeted by big layoffs at Wells Fargo & Co. and the former Aviva USA insurance company, now known as Athene. The Iowa unemployment rate increased to 4.9 percent in August from 4.8 percent in July, but it remains one of the lowest in the U.S.

via Blue Bunny ice cream manufacturer to lay off 58 workers | The Des Moines Register | desmoinesregister.com.

Memo to Blue Bell and Braum’s:

Bigger is not always better.

Testosterone Treatment Tied to Worse Cardiac Outcomes

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After adjustment for the presence of coronary artery disease, testosterone therapy was associated with a greater risk of all-cause mortality, myocardial infarction, and ischemic stroke 3 years after angiography (25.7% versus 19.9%; HR 1.29, 95% CI 1.04-1.58), according to P. Michael Ho, MD, PhD, of the Department of Veterans Affairs (VA) Eastern Colorado Health Care System in Denver, and colleagues.

via Testosterone Tx Tied to Worse Cardiac Outcomes.

How come the television commercials don’t tell you this information when they try to make you think you have a disease called Low T?

Annual prescriptions for testosterone increased more than five-fold from 2000 to 2011. In 2011, the total number of prescriptions numbered 5.3 million and make up a market of 1.6 billion, the authors wrote.

Never mind.

Calcium Score Beats Lipids for Telling CVD Risk

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Measurement of coronary artery calcium stratified patient risk for cardiovascular disease regardless of dyslipidemia burden or definition, researchers found.

When measured across lipid abnormality categories, patients with a coronary artery calcium score of 100 or more had a 22.2 to 29.2 incidents of cardiovascular disease per 1,000 person-years versus 2.4 to 6.2 events per 1,000 person-years among those with arterial calcium scores of 0, according to Khurram Nasir, MD, MPH, of Baptist Health South Florida in Miami Beach, and colleagues.

via Calcium Score Beats Lipids for Telling CVD Risk.

N-Terminal Probrain Natriuretic Peptide Is a Stronger Predictor of Cardiovascular Mortality Than C-Reactive Protein and Albumin Excretion Rate in Elderly Patients With Type 2 Diabetes

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NT-proBNP is a strong independent predictor of short-term CV mortality risk in elderly people with type 2 diabetes, including those without preexisting CVD. This association is evident even in people with slightly increased values, is not modified by CRP, and is additive to that provided by AER.

via N-Terminal Probrain Natriuretic Peptide Is a Stronger Predictor of Cardiovascular Mortality Than C-Reactive Protein and Albumin Excretion Rate in Elderly Patients With Type 2 Diabetes.