Predictive Ability of CRP Questioned

Medical News: AHA: Value of Measuring CRP Questioned – in Meeting Coverage, AHA from MedPage Today

“In patients who already have a reason to be on a statin, C-reactive protein (CRP) measurement does not appear to provide any additional information about cardiovascular risk beyond traditional factors, a secondary analysis of the ASCOT trial showed.”

CRP as Risk Factor for CHD

C-Reactive Protein as a Risk Factor for Coronary Heart Disease: A Systematic Review and Meta-analyses for the U.S. Preventive Services Task Force — Ann Intern Med

Conclusion: Strong evidence indicates that CRP is associated with CHD events. Moderate, consistent evidence suggests that adding CRP to risk prediction models among initially intermediate-risk persons improves risk stratification. However, sufficient evidence that reducing CRP levels prevents CHD events is lacking.

 

CRP Meta-Analysis

C-Reactive Protein as a Risk Factor for Coronary Heart Disease: A Systematic Review and Meta-Analyses for the U.S. Preventive Services Task Force

Strong evidence indicates that CRP is associated with CHD events. Moderate, consistent evidence suggests that adding CRP to risk prediction models among initially intermediate-risk persons improves risk stratification. However, sufficient evidence that reducing CRP levels prevents CHD events is lacking.