Diabetic foot ulcers occur as a result of various factors, such as mechanical changes in conformation of the bony architecture of the foot, peripheral neuropathy, and atherosclerotic peripheral arterial disease, all of which occur with higher frequency and intensity in the diabetic population. Diabetic foot lesions are responsible for more hospitalizations than any other complication of diabetes. Among patients with diabetes, 15% develop a foot ulcer, and 12%-24% of individuals with a foot ulcer require amputation. Diabetes is the leading cause of nontraumatic lower-extremity amputations in the United States.
diabetes
Guiding Principles for Diabetes Care – NDEP
Guiding Principles for Diabetes Care | NDEP.
The guiding principles are available online or in pdf format.
Effect of Body Mass Index on Insulin Secretion or Sensitivity and Diabetes – American Journal of Preventive Medicine
Background
Although the association between obesity and diabetes is well known, the factors predisposing to diabetes in non-obese Asians are less clearly characterized.
Conclusions
Individuals with normal BMI may develop diabetes mainly through IIS, whereas individuals with high BMI may develop diabetes primarily through IR.
I am so screwed.
Body Mass Index and the Risk of All-Cause Mortality Among Patients with Type 2 Diabetes
Body Mass Index and the Risk of All-Cause Mortality Among Patients with Type 2 Diabetes.
Conclusions—The current study indicated a U-shaped association of BMI with all-cause mortality risk among African American and white patients with type 2 diabetes. A significantly increased risk of all-cause mortality was observed among African Americans with BMI<30 kg/m2 and BMI ≥35 kg/m2, and among whites with BMI<25 kg/m2 and BMI ≥40 kg/m2 compared with patients with BMI 30-34.9 kg/m2.
Assessment of the Relative Effectiveness and Tolerability of Treatments of Type 2 Diabetes Mellitus: A Network Meta-analysis – Clinical Therapeutics
Efficacy and Safety of Linagliptin in Subjects With Long-Standing Type 2 Diabetes Mellitus >10 Years: Evidence From Pooled Data of Randomized, Double-Blind, Placebo-Controlled, Phase III Trials – Clinical Therapeutics
Diet Soda May Alter Our Gut Microbes And Raise The Risk Of Diabetes : The Salt : NPR
Now, a new study published in the journal Nature introduces a new idea: Diet sodas may alter our gut microbes in a way that increases the risk of metabolic diseases such as Type 2 diabetes — at least in some of us.
In the paper, researchers at the Weizmann Institute of Science in Israel describe what happened when they fed zero-calorie sweeteners, including saccharin, aspartame and sucralose, to mice.
“To our surprise, [the mice] developed glucose intolerance,” Weizmann researcher Eran Elinav tells us.
Diet Soda May Alter Our Gut Microbes And Raise The Risk Of Diabetes : The Salt : NPR.
Diabetes and the Heart: Risk Greater in Women
Diabetes and the Heart: Risk Greater in Women.
Data from 64 studies with both male and female participants yielded a 44% greater multiple-adjusted relative risk ratio (RRR) for incident coronary heart disease (CHD) in women compared with men (RRR 1.44, 95% CI 1.27-1.63), Rachel Huxley, DPhil, of the University of Queensland in Sydney, Australia, and colleagues found.
Pooled data from 52 studies indicated that women also had a 44% greater chance than men of dying from fatal CHD associated with diabetes, Huxley and colleagues reported online in the journal Diabetologia.
Proliferative Retinopathy in Type 1 Diabetes Is Associated With Cerebral Microbleeds, Which Is Part of Generalized Microangiopathy
CONCLUSIONS: In PDR+ patients, cerebral microbleed prevalence was higher and seems part of generalized microangiopathy that may affect the skin and the brain.
Association of Race/Ethnicity, Inflammation, and Albuminuria in Patients With Diabetes and Early Chronic Kidney Disease
CONCLUSIONS: AAs and Hispanics with diabetes have a higher prevalence of early CKD compared with whites, which is significantly associated with UAE and/or CRP.
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