Trends in Prescription Opioids Detected in Fatally Injured Drivers in 6 US States: 1995–2015 | AJPH | Ahead of Print

Results. The prevalence of prescription opioids detected in fatally injured drivers increased from 1.0% (95% confidence interval [CI] = 0.5, 1.4) in 1995 to 7.2% (95% CI = 5.7, 8.8) in 2015 (Z = −9.04; P < .001). Prescription opioid prevalence was higher in female than in male drivers (4.4% vs 2.9%; P < .001). Of the drivers testing positive for prescription opioids, 30.0% had elevated blood alcohol concentrations (≥ 0.01 g/dL), and 66.9% tested positive for other drugs.

Source: Trends in Prescription Opioids Detected in Fatally Injured Drivers in 6 US States: 1995–2015 | AJPH | Ahead of Print

Houston…we have a problem.

FDA Adds New Warnings to All Testosterone Product Labels

Testosterone and other AAS, which have a schedule III classification by the Controlled Substances Act, may be abused by adults and adolescents, including athletes and body builders.

“Abuse of testosterone, usually at doses higher than those typically prescribed and usually in conjunction with other AAS, is associated with serious safety risks affecting the heart, brain, liver, mental health, and endocrine system,” the FDA notes.

Reported serious adverse outcomes include myocardial infarction, heart failure, stroke, depression, hostility, aggression, liver toxicity, and male infertility. People abusing high doses of testosterone have also reported withdrawal symptoms, such as depression, fatigue, irritability, loss of appetite, decreased libido, and insomnia, the agency says.

Source: FDA Adds New Warnings to All Testosterone Product Labels

Source: Safety Alerts for Human Medical Products > Testosterone and Other Anabolic Androgenic Steroids (AAS): FDA Statement – Risks Associated With Abuse and Dependence

It is interesting you no longer see those Low-T commercials on television any more.  Really?  Just another clever marketing campaign to create a disease that doesn’t exist along with a convenient drug based solution.  What side effects?

Read this book.  Now.

Source: Bill Moyers Journal . Profile . Melody Petersen | PBS

Cardiac Effects of Loperamide OD – The Poison Review

Source: Cardiac effects of loperamide overdose | The Poison Review

Just when you start to think you’ve heard it all you stumble upon this article.  I’ve never thought about taking mass quantities of anti-diarrheal medication for the purpose of getting high.

A little-known manifestation of loperamide toxicity is cardiac dysrhythmias. This case report describes a 48-year-old woman who had ingested up to 40 tablets 2-mg loperamide daily for several weeks to “get a high.”
I’m practically speechless.

Cannabis-Related ED Visits Rise in States With Legalized Use

Cannabis-Related ED Visits Rise in States With Legalized Use.

A second poster presented at the AAAP meeting examined “impact on the healthcare system” and showed that 10,532,658 ED visits due to any type of substance abuse occurred between 2007 and 2011 in the United States.

During that period, cannabis-related ED visits increased 67.8%, and alcohol-related visits increased by 49%. Also increasing were visits related to opioids (by 42%), hallucinogens (40.4%), sedatives (40%), and amphetamines (20.6%).

Interestingly, the percentage of visits related to cocaine use decreased by 67.9%.

 

“This poster is definitely starting to bring out some of the real concerns that I have as a healthcare provider ― that you are exposing more people to higher potency and riskier forms of the substance. This is not the shake weed that somebody smoked in the ’70s. This is four times more potent. It’s a much riskier proposition than a lot of people think.”  Dr Ryan Caldeiro