Tom Petty’s COD Lesson for Underwriters

Good article from The Dose Makes the Poison blog.  You can read the entire article here.

I found the following excerpt fascinating.  The bold lines are my highlights.

From a general forensic toxicology standpoint, the real takeaway is that this is a dangerous combination of substances to use concurrently. He was consuming two powerful opioid and two potent benzodiazepines which when used together can create synergistic effects and exaggerated central nervous system depression. Add that situation to an already compromised cardiovascular and respiratory system, and it’s a recipe for disaster.  For my own information, I would love to see the full toxicology report with quantitative measures of drug, etc. How much fentanyl was present? How much temazepam and alprazolam were detected? Not that any of that really matters though.

With the detection of acetylfentanyl and despropionylfentanyl, it seems as if Tom Petty was supplementing his pharmaceutical medications with illicitly manufactured substances. Acetylfentanyl is not a pharmaceutical medication anywhere in the world and is only found as a designer opioid/analog meant to skirt the controlled substances act in the USA. Fentanyl does not metabolize to acetylfentanyl. As despropionylfentanyl is a precursor/intermediate used in the illicit (non-pharmaceutical) synthesis of fentanyl, it generally used as a marker for exposure to illicitly manufactured fentanyl. The presence of this substance has also been associated with the use of various fentanyl analogs including acetylfentanyl, acrylfentanyl, and furanylfentanyl. No one knows if the use of illicit opioid was intentional or not. Remember the situation surrounding Prince’s death. Multiple pills were found in his residence that looked like pharmaceutical hydrocodone/acetaminophen but turned out to be counterfeit tablets containing fentanyl and the opioid research chemical U-47700.

As a conclusion, I’ll say, please do not mix depressant drugs. Do not mix opioids with benzodiazepines. Do not mix either of them with ethanol. Stay safe, folks.

Pay attention to those medications.

Didn’t I mention this previously when writing about Heath Ledger’s death?

Opioid Overdose Deaths Keep Rising | Medpage Today

Following a relative plateau around 16,000 deaths per year, prescription opioid overdose deaths shot up 16% in 1 year to 18,893 deaths in 2014, Rose Rudd, MSPH, of the CDC, and colleagues reported in Morbidity & Mortality Weekly Report. Heroin deaths also continued to jump, reaching 10,574 that year, up from about 8,000 in 2013. The latest rate is nearly three times the heroin overdose rate in 2010, the CDC said.

Source: Opioid Overdose Deaths Keep Rising | Medpage Today


Poisoning Deaths Involving Opioid Analgesics — New York State, 2003–2012

Comparison of opioid analgesic-related mortality between those enrolled or not enrolled in Medicaid shows considerably higher death rates and a more rapid increase in mortality among Medicaid enrollees. The consistently higher age-adjusted death rates for poisonings involving opioid analgesics among Medicaid enrollees (after stratifying data by sex) suggest that differences in age and sex distributions do not underlie these Medicaid/non-Medicaid differences. Other factors, such as the greater prevalence of mental illness and substance abuse in the Medicaid population (6), might contribute to the observed differences.

via Poisoning Deaths Involving Opioid Analgesics — New York State, 2003–2012.

Maybe the title should be Socioeconomic Status and Death.

Deaths From Narcotic Painkillers Quadrupled in Past Decade: CDC – WebMD

Deaths From Narcotic Painkillers Quadrupled in Past Decade: CDC – WebMD.

Deaths from overdoses of drugs such as hydrocodone (Vicodin), morphine and oxycodone (Oxycontin) climbed from 1.4 per 100,000 people to 5.4 per 100,000, according to the U.S. Centers for Disease Control and Prevention.

That means about 3,000 people died in 1999 from unintentional overdoses. By 2011, that number was up to nearly 12,000 deaths, the report said.

Killing Pain: Script by Script

Primary care doctors wrote about 53 million benzodiazepine prescriptions in 2013, roughly four times the number written by psychiatrists, a group that penned 13 million benzo scripts.

Nurse practitioners and physician assistants were close behind with 11 million prescriptions for the drugs, according to data obtained by MedPage Today and the Milwaukee Journal Sentinel.

In 2013, non-doctors wrote 30 million opioid prescriptions, compared with 92 million written by primary care doctors that year, according to data provided by IMS Health, a drug market research firm.

In 2010, the most recent year for which data were available, 30% of the 16,651 people who died of an opioid overdose also had taken a benzodiazepine, according to the U.S. Centers for Disease Control and Prevention.

via Killing Pain: Script by Script.

Killing Pain: Benzo ‘Boost’ Can Be Deadly.

Killing Pain: Xanax Tops Charts.